Circular RNA in Liver: Health and Diseases

Song, Meiyi; Xia, Lu; Sun, Manyi; Yang, Changqing; Wang, Fei

doi:10.1007/978-981-13-1426-1_20

Cited by 24 publications

(17 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,5,8,13,18,19 Recent studies have confirmed that circRNA is involved in the regulation of gene expression by various means, thereby indirectly participating in the occurrence and development of various solid cancers. 6,[9][10][11]13,14,16,17 However, the biological functions of circRNA in BC are scarcely reported. In this study, we investigated the expression of hsa_circ_0068033 expression in BC tissues and cell lines and explored the influence of overexpressed hsa_circ_0068033 on the biological characteristics of MCF-7 and MDA-MB-231.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 In addition, circRNA can directly bind to proteins, or establish an indirect RNA-mediated association with proteins to influence their functions. 8 Studies have reported that circRNA is closely correlated with the occurrence and development of various malignant tumors, including liver cancer, 9,10 lung cancer, 11,12 cervical cancer 13 gastric cancer, 14,15 colorectal cancer, 16,17 etc. In recent years, the potential applications of circRNA in the regulation of biological functions and the clinical diagnosis and prognosis of BC have received considerable attention.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

<p>Circular RNA hsa_circ_0068033 Acts as a Diagnostic Biomarker and Suppresses the Progression of Breast Cancer Through Sponging miR-659</p>

Yuan¹,

Lei²,

Dong³

et al. 2020

OTT

View full text Add to dashboard Cite

Purpose: Recently, dysregulated circular RNAs (circRNAs) have been associated with the progression of numerous malignant tumors. However, the mechanism through which circRNAs participate in breast cancer (BC) remains unclear. This study was designed to illustrate the role of hsa_circ_0068033 in BC. Methods: We detected the expression levels of hsa_circ_0068033 in BC tissues using quantitative real-time PCR (qRT-PCR) and in situ hybridization (ISH). A series of functional experiments were conducted to assess the function of hsa_circ_0068033 in BC development and the underlying mechanisms. Results: The results suggested that the expression of hsa_circ_0068033 was downregulated in BC tissues, and its expression was markedly correlated with tumor size (P=0.021), and the Tumor, Node, and Metastasis stage (P=0.023). Receiver operating characteristic analysis showed that hsa_circ_0068033 testing yielded an area under the curve value of 0.8480 in discriminating BC from non-tumor controls. Functionally, in-vitro experiments demonstrated that overexpression of hsa_circ_0068033 could inhibit the growths, clone formation, invasion and migration of MCF-7 and MDA-MB-231 cells while activating the intrinsic apoptotic pathway to induce apoptosis. The xenograft experiment revealed that exogenous hsa_circ_0068033 is able to evidently reduce the tumorigenic ability of MDA-MB-231 cells in nude mice. Rescue assays further proved that hsa_circ_0068033 exerts biological functions by sponging miR-659. Conclusion: Collectively, this study revealed for the first time that hsa_circ_0068033 acts as a tumor suppressor gene in BC, and the hsa_circ_0068033/miR-659 axis participates in the progression of BC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Circular RNA hsa_circ_0068033 Acts as a Diagnostic Biomarker and Suppresses the Progression of Breast Cancer Through Sponging miR-659</p>

Yuan¹,

Lei²,

Dong³

et al. 2020

OTT

View full text Add to dashboard Cite

show abstract

“…CircRNA, a class of enclosed non-coding RNA molecules generated by RNA splicing, function as an miRNA sponge and regulate gene transcription and alternative splicing [18,19,8,13,4,5]. Recent studies have confirmed that circRNA is involved in the regulation of gene expression by various means, thereby indirectly participating in the occurrence and development of various solid cancers [13,11,10,6,17,9,16,14].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, circRNA can directly bind to proteins, or establish an indirect RNA-mediated association with proteins to influence their functions [8]. Studies have reported that circRNA is closely correlated with the occurrence and development of various malignant tumors, including liver cancer [9,10], lung cancer [11,12], cervical cancer [13] gastric cancer [14,15], colorectal cancer [16,17], etc. In recent years, the potential applications of circRNA in the regulation of biological functions and the clinical diagnosis and prognosis of BC have received considerable attention.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA hsa_circ_0068033 inhibits proliferation and invasion of breast cancer cells through sponging miR-659

Yuan

Lei

Liu

2019

Preprint

View full text Add to dashboard Cite

Recently, dysregulated circular RNAs (circRNAs) have been associated with the progression of numerous malignant tumors. However, the mechanism through which circRNAs participate in breast cancer (BC) remains unclear. This study was designed to illustrate the role of hsa_circ_0068033 in BC. A series of functional experiments were conducted to assess the function of hsa_circ_0068033 in the development of BC and the underlying mechanisms. The results suggested that the expression of hsa_circ_0068033 was downregulated in BC tissues, and markedly correlated with tumor size (P=0.021) and the Tumor, Node, and Metastasis stage (P=0.023). Receiver operating characteristic analysis showed that hsa_circ_0068033 testing yielded an area under the curve value of 0.8480 in discriminating BC from non-tumor controls.Functionally, overexpression of hsa_circ_0068033 could inhibit the growth, clone formation, invasion, and migration of MCF-7 and MDA-MB-231 cells, while activating the intrinsic apoptotic pathway to induce apoptosis. The xenograft experiment revealed that exogenous hsa_circ_0068033 is able to reduce the tumorigenic ability of MDA-MB-231 cells in nude mice. Rescue assays further proved that hsa_circ_0068033 exerts biological functions by sponging miR-659. This study revealed for the first time that hsa_circ_0068033 acts as a tumor suppressor gene in BC, and the hsa_circ_0068033/miR-659 axis participates in the progression of BC.

show abstract

“…Because of their diverse functions, circRNAs not only regulate fundamental biological processes, but also play critical roles in a wide spectrum of human diseases including cancer [71][72][73][74][75][76]. Importantly, circRNAs are resistant to exoribonucleases and are therefore stable in the circulation, which makes them promising biomarkers for cancer diagnosis and prognosis.…”

Section: Overview Of Circrnasmentioning

confidence: 99%

Circular RNAs in renal cell carcinoma: implications for tumorigenesis, diagnosis, and therapy

et al. 2020

View full text Add to dashboard Cite

Renal cell carcinoma (RCC) is the most common malignant kidney tumor and has a high incidence rate. Circular RNAs (circRNAs) are noncoding RNAs with widespread distribution and diverse cellular functions. They are highly stable and have organ- and tissue-specific expression patterns. CircRNAs have essential functions as microRNA sponges, RNA-binding protein- and transcriptional regulators, and protein translation templates. Recent reports have shown that circRNAs are abnormally expressed in RCC and act as important regulators of RCC carcinogenesis and progression. Moreover, circRNAs have emerged as potential biomarkers for RCC diagnosis and prognosis and targets for developing new treatments. However, further studies are needed to better understand the functions of circRNAs in RCC. In this review, we summarize and discuss the recent research progress on RCC-associated circRNAs, with a focus on their potential for RCC diagnosis and targeted therapy.

show abstract

Circular RNA in Liver: Health and Diseases

Cited by 24 publications

References 121 publications

<p>Circular RNA hsa_circ_0068033 Acts as a Diagnostic Biomarker and Suppresses the Progression of Breast Cancer Through Sponging miR-659</p>

<p>Circular RNA hsa_circ_0068033 Acts as a Diagnostic Biomarker and Suppresses the Progression of Breast Cancer Through Sponging miR-659</p>

Circular RNA hsa_circ_0068033 inhibits proliferation and invasion of breast cancer cells through sponging miR-659

Circular RNAs in renal cell carcinoma: implications for tumorigenesis, diagnosis, and therapy

Contact Info

Product

Resources

About