Circular RNA-protein interactions: functions, mechanisms, and identification

Huang, Anqing; Zheng, Haoxuan; Wu, Zhimin; Chen, Minsheng; Huang, Yuli

doi:10.7150/thno.42174

Cited by 560 publications

(425 citation statements)

References 116 publications

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“…Several circRNAs were suggested to sequester HuR, an extensively studied RNA-binding protein, which consequently affects its action on target gene regulation [38][39][40]. The interactions between circRNAs and RNA-binding proteins have been shown to influence cancer progression [41]. In addition, circRNAs were observed to act as dynamic scaffolds that bring different proteins together to form a complex [41].…”

Section: Protein Sponge and Scaffoldmentioning

confidence: 99%

“…The interactions between circRNAs and RNA-binding proteins have been shown to influence cancer progression [41]. In addition, circRNAs were observed to act as dynamic scaffolds that bring different proteins together to form a complex [41]. In mouse fibroblast cells, circ-Foxo3 can interact with both p21 and CDK2 to form a ternary complex that results in the inhibition of cell cycle progression [42].…”

Section: Protein Sponge and Scaffoldmentioning

confidence: 99%

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The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

Dong

Xiong

et al. 2020

Cancers

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Circular RNAs (circRNAs) are covalently closed, endogenous non-coding RNAs and certain circRNAs are linked to human tumors. Owing to their circular form, circRNAs are protected from degradation by exonucleases, and therefore, they are more stable than linear RNAs. Many circRNAs have been shown to sponge microRNAs, interact with RNA-binding proteins, regulate gene transcription, and be translated into proteins. Mounting evidence suggests that circRNAs are dysregulated in cancer tissues and can mediate various signaling pathways, thus affecting tumorigenesis, metastasis, and remodeling of the tumor microenvironment. First, we review the characteristics, biogenesis, and biological functions of circRNAs, and describe various mechanistic models of circRNAs. Then, we provide a systematic overview of the functional roles of circRNAs in gynecological cancers. Finally, we describe the potential future applications of circRNAs as biomarkers for prognostic stratification and as therapeutic targets in gynecological cancers. Although the function of most circRNAs remains elusive, some individual circRNAs have biologically relevant functions in cervical cancer, ovarian cancer, and endometrial cancer. Certain circRNAs have the potential to serve as biomarkers and therapeutic targets in gynecological cancers.

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Section: Protein Sponge and Scaffoldmentioning

confidence: 99%

Section: Protein Sponge and Scaffoldmentioning

confidence: 99%

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

Dong

Xiong

et al. 2020

Cancers

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“…The mechanism of exosomal circRNA in the regulation of osteogenic differentiation is seldom studied. However, the circular structure of cir-cRNA makes it more stable than linear RNA and difficult to be degraded [82]. It has great research potential in exosome engineering.…”

Section: Lncrnamentioning

confidence: 99%

Exosome: A Novel Nanocarrier Delivering Noncoding RNA for Bone Tissue Engineering

Liu

Cao

Zhu

et al. 2020

Journal of Nanomaterials

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Bone growth and metabolism are mainly regulated by a series of intracellular molecules and extracellular stimuli. Exosome, as a nanoscale substance secreted to the outside of the cells, plays an extensive role in intercellular communication. This review provides theoretical references and evidences for further exploration of exosomes as noncoding RNA carriers to regulate bone tissue recovery through the following aspects: (1) basic characteristics of exosomes, (2) research progress of exosomal noncoding RNA in bone tissue engineering, (3) current status and advantages of engineering exosomes as nanocarriers for noncoding RNA delivery, and (4) problems and application prospects of exosome therapy in the field of orthopedics.

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“…Circular RNAs are able to interact with a significant number of RBPs in the cytoplasm; those proteins are involved in the biogenesis of circRNAs and work hand in hand in various cellular pathways, similar to other protein-coding and non-coding RNAs [ 106 ]. Currently, the role of such interactions is poorly understood and the significance of such interactions is still under discussion, given the relatively low concentration of circRNAs in the cells [ 79 ].…”

Section: The Role Of Rna Binding Proteins (Rbps) In Schizophreniamentioning

confidence: 99%

The Biomarker and Therapeutic Potential of Circular Rnas in Schizophrenia

Nedoluzhko

Gruzdeva

Sharko

et al. 2020

Cells

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Circular RNAs (circRNAs) are endogenous, single-stranded, most frequently non-coding RNA (ncRNA) molecules that play a significant role in gene expression regulation. Circular RNAs can affect microRNA functionality, interact with RNA-binding proteins (RBPs), translate proteins by themselves, and directly or indirectly modulate gene expression during different cellular processes. The affected expression of circRNAs, as well as their targets, can trigger a cascade of events in the genetic regulatory network causing pathological conditions. Recent studies have shown that altered circular RNA expression patterns could be used as biomarkers in psychiatric diseases, including schizophrenia (SZ); moreover, circular RNAs together with other cell molecules could provide new insight into mechanisms of this disorder. In this review, we focus on the role of circular RNAs in the pathogenesis of SZ and analyze their biomarker and therapeutic potential in this disorder.

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Circular RNA-protein interactions: functions, mechanisms, and identification

Cited by 560 publications

References 116 publications

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

Exosome: A Novel Nanocarrier Delivering Noncoding RNA for Bone Tissue Engineering

The Biomarker and Therapeutic Potential of Circular Rnas in Schizophrenia

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