Circular RNA-regulated autophagy is involved in cancer progression

Zhou, Xinping; Lin, Jun‐Tao; Wang, Feifan; Chen, Xianwu; Zhang, Yan; Hu, Zhenghui; Jin, Xiaodong

doi:10.3389/fcell.2022.961983

Cited by 8 publications

(3 citation statements)

References 160 publications

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“…In melanoma cells, miR-23a overexpression inhibits autophagy by targeting ATG12 via the AMPK-RhoA pathway (Guo et al, 2017). CircRNAs regulate autophagy by acting as miRNA sponges or binding to RNA binding proteins (Zhou et al, 2022a). Binding of circRNAs to specific miRNAs is a key pathway that affects the autophagy process, such as CircEEF2 and miR-6881-3p (Yong et al, 2020), circCDYL and miR-1275 (Liang et al, 2020), circMTO1 and miR-6893 (Chen et al, 2019).…”

Section: Noncoding Rnas and Autophagymentioning

confidence: 99%

Noncoding RNAs: the crucial role of programmed cell death in osteoporosis

Han,

Zhu,

Zhang

et al. 2024

Front. Cell Dev. Biol.

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Osteoporosis is the most common skeletal disease characterized by an imbalance between bone resorption and bone remodeling. Osteoporosis can lead to bone loss and bone microstructural deterioration. This increases the risk of bone fragility and fracture, severely reducing patients’ mobility and quality of life. However, the specific molecular mechanisms involved in the development of osteoporosis remain unclear. Increasing evidence suggests that multiple noncoding RNAs show differential expression in the osteoporosis state. Meanwhile, noncoding RNAs have been associated with an increased risk of osteoporosis and fracture. Noncoding RNAs are an important class of factors at the level of gene regulation and are mainly involved in cell proliferation, cell differentiation, and cell death. Programmed cell death is a genetically-regulated form of cell death involved in regulating the homeostasis of the internal environment. Noncoding RNA plays an important role in the programmed cell death process. The exploration of the noncoding RNA-programmed cell death axis has become an interesting area of research and has been shown to play a role in many diseases such as osteoporosis. In this review, we summarize the latest findings on the mechanism of noncoding RNA-mediated programmed cell death on bone homeostasis imbalance leading to osteoporosis. And we provide a deeper understanding of the role played by the noncoding RNA-programmed cell death axis at the gene regulatory level of osteoporosis. We hope to provide a unique opportunity to develop novel diagnostic and therapeutic approaches for osteoporosis.

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Section: Noncoding Rnas and Autophagymentioning

confidence: 99%

Noncoding RNAs: the crucial role of programmed cell death in osteoporosis

Han,

Zhu,

Zhang

et al. 2024

Front. Cell Dev. Biol.

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“…Autophagy is observed in nearly every type of eukaryotic cells and is a pervasive and highly conserved catabolic process ( Zhou et al, 2022 ). This degradative process is central to cellular regulation, maintaining homeostasis by lysosomal breakdown of injured organelles and various proteins ( Chen et al, 2021 ; Wang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The role of LncRNA-mediated autophagy in cancer progression

Liu,

Tang,

Yang

et al. 2024

Front. Cell Dev. Biol.

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Long non-coding RNAs (lncRNAs) are a sort of transcripts that are more than 200 nucleotides in length. In recent years, many studies have revealed the modulatory role of lncRNAs in cancer. Typically, lncRNAs are linked to a variety of essential events, such as apoptosis, cellular proliferation, and the invasion of malignant cells. Simultaneously, autophagy, an essential intracellular degradation mechanism in eukaryotic cells, is activated to respond to multiple stressful circumstances, for example, nutrient scarcity, accumulation of abnormal proteins, and organelle damage. Autophagy plays both suppressive and promoting roles in cancer. Increasingly, studies have unveiled how dysregulated lncRNAs expression can disrupt autophagic balance, thereby contributing to cancer progression. Consequently, exploring the interplay between lncRNAs and autophagy holds promising implications for clinical research. In this manuscript, we methodically compiled the advances in the molecular mechanisms of lncRNAs and autophagy and briefly summarized the implications of the lncRNA-mediated autophagy axis.

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“…The circRNAs are a type of small RNA molecules characterized by their closed-loop structure that is formed by the exon skipping or reverse splicing of pre-mRNA transcripts, rendering them resistant to enzymatic degradation and thus highly stable within living organisms ( Lee et al, 2022 ; Ren et al, 2022 ). Initially, circRNAs were deemed to be non-functional within the human body; however, the advent of high-throughput sequencing techniques has identified their extensive presence in various organs and tissues of the body, where they play crucial biological roles ( Yuan et al, 2022 ; Zhou et al, 2022 ). Multiple studies have proposed that circRNAs contribute to essential physiological processes, such as tumorigenesis and development, and are inextricably linked to cancer cell proliferation, invasiveness, and metastasis ( Chen et al, 2022a ; Kim et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Circular RNAs in gynecologic cancers: mechanisms and implications for chemotherapy resistance

2023

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Chemotherapy resistance remains a major challenge in the treatment of gynecologic malignancies. Increasing evidence suggests that circular RNAs (circRNAs) play a significant role in conferring chemoresistance in these cancers. In this review, we summarize the current understanding of the mechanisms by which circRNAs regulate chemotherapy sensitivity and resistance in gynecologic malignancies. We also discuss the potential clinical implications of these findings and highlight areas for future research. CircRNAs are a novel class of RNA molecules that are characterized by their unique circular structure, which confers increased stability and resistance to degradation by exonucleases. Recent studies have shown that circRNAs can act as miRNA sponges, sequestering miRNAs and preventing them from binding to their target mRNAs. This can lead to upregulation of genes involved in drug resistance pathways, ultimately resulting in decreased sensitivity to chemotherapy. We discuss several specific examples of circRNAs that have been implicated in chemoresistance in gynecologic cancers, including cervical cancer, ovarian cancer, and endometrial cancer. We also highlight the potential clinical applications of circRNA-based biomarkers for predicting chemotherapy response and guiding treatment decisions. Overall, this review provides a comprehensive overview of the current state of knowledge regarding the role of circRNAs in chemotherapy resistance in gynecologic malignancies. By elucidating the underlying mechanisms by which circRNAs regulate drug sensitivity, this work has important implications for improving patient outcomes and developing more effective therapeutic strategies for these challenging cancers.

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Circular RNA-regulated autophagy is involved in cancer progression

Cited by 8 publications

References 160 publications

Noncoding RNAs: the crucial role of programmed cell death in osteoporosis

Noncoding RNAs: the crucial role of programmed cell death in osteoporosis

The role of LncRNA-mediated autophagy in cancer progression

Circular RNAs in gynecologic cancers: mechanisms and implications for chemotherapy resistance

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