Circular RNA regulation and function in drug seeking phenotypes

Sillivan, Stephanie E.; Gillespie, Aria

doi:10.1016/j.mcn.2023.103841

Cited by 4 publications

(2 citation statements)

References 93 publications

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“…Additional circRNA activities have been reported, although being limitingly investigated 55 . Emerging evidence indicate that circRNAs can bind to proteins, including RNA-binding proteins, in order to regulate the expression of target genes 56 , 57 . This specific protein-binding ability on RNA-binding proteins confers to circRNAs the ability of controlling the maturation/splicing of mRNAs 58 , 59 .…”

Section: Circular Rna Functionsmentioning

confidence: 99%

“…This specific protein-binding ability on RNA-binding proteins confers to circRNAs the ability of controlling the maturation/splicing of mRNAs 58 , 59 . Indeed, circRNAs can affect the spliceosome activity by competing with pre-mRNA molecules, modulating, in turn, the expression of transcribed genes 56 . CircRNAs can also directly mediate the sequestration of various RNA-binding proteins through a protein sponge mechanism, and further negatively regulate the expression of downstream genes.…”

Section: Circular Rna Functionsmentioning

confidence: 99%

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Regulatory mechanisms of circular RNAs during human mesenchymal stem cell osteogenic differentiation

Mazziotta,

Badiale,

Cervellera

et al. 2024

Theranostics

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Human osteogenic differentiation is a complex and well-orchestrated process which involves a plethora of molecular players and cellular processes. A growing number of studies have underlined that circular RNAs (circRNAs) play an important regulatory role during human osteogenic differentiation. CircRNAs are single-stranded, covalently closed non-coding RNA molecules that are acquiring increased attention as epigenetic regulators of gene expression. Given their intrinsic high conformational stability, abundance, and specificity, circRNAs can undertake various biological activities in order to regulate multiple cellular processes, including osteogenic differentiation. The most recent evidence indicates that circRNAs control human osteogenesis by preventing the inhibitory activity of miRNAs on their downstream target genes, using a competitive endogenous RNA mechanism. The aim of this review is to draw attention to the currently known regulatory mechanisms of circRNAs during human osteogenic differentiation. Specifically, we provide an understanding of recent advances in research conducted on various human mesenchymal stem cell types that underlined the importance of circRNAs in regulating osteogenesis. A comprehensive understanding of the underlying regulatory mechanisms of circRNA in osteogenesis will improve knowledge on the molecular processes of bone growth, resulting in the potential development of novel preclinical and clinical studies and the discovery of novel diagnostic and therapeutic tools for bone disorders.

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