Circular RNAs in cancer: new insights into functions and implications in ovarian cancer

Shabaninejad, Zahra; Vafadar, Asma; Movahedpour, Ahmad; Ghasemi, Younes; Namdar, Afshin; Fathizadeh, Hadis; Pourhanifeh, Mohammad Hossein; Mirzaei, Hamed

doi:10.1186/s13048-019-0558-5

Cited by 115 publications

(76 citation statements)

References 102 publications

(91 reference statements)

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“…In fact, the non-coding RNAs represent the RNA, which would not encode a protein and thus may be categorized into multiple groups like the long non-coding RNAs (lncRNAs = above 200 nucleotides in length) and small non-coding RNAs (like microRNAs = approximately 19 to 22 nucleotides in length) [137][138][139][140][141]. Finally, it has been found that that microRNAs (miRNAs) regulated translational effectiveness or stability of the targeted mRNAs via interactions with 3′-un-translated region (3′-UTR) of the respective targets [142][143][144][145][146][147].…”

Section: Micrornasmentioning

confidence: 99%

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

2020

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Cancer stem cells (CSCs) have been identified as a little population of cancer cells, which have features as the same as the cells normal stem cells. There is enough knowledge of the CSCs responsibility for metastasis, medicine resistance, and cancer outbreak. Therefore, CSCs control possibly provides an efficient treatment intervention inhibiting tumor growth and invasion. In spite of the significance of targeting CSCs in treating cancer, few study comprehensively explored the nature of oral CSCs. It has been showed that oral CSCs are able to contribute to oral cancer progression though activation/inhibition a sequences of cellular and molecular pathways (microRNA network, histone modifications and calcium regulation). Hence, more understanding about the properties of oral cancers and their behaviors will help us to develop new therapeutic platforms. Head and neck CSCs remain a viable and intriguing option for targeted therapy. Multiple investigations suggested the major contribution of the CSCs to the metastasis, tumorigenesis, and resistance to the new therapeutic regimes. Therefore, experts in the field are examining the encouraging targeted therapeutic choices. In spite of the advancements, there are not enough information in this area and thus a magic bullet for targeting and eliminating the CSCs deviated us. Hence, additional investigations on the combined therapies against the head and neck CSCs could offer considerable achievements. The present research is a review of the recent information on oral CSCs, and focused on current advancements in new signaling pathways contributed to their stemness regulation. Moreover, we highlighted various therapeutic approaches against oral CSCs.

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Section: Micrornasmentioning

confidence: 99%

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

2020

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“…In recent years, numerous studies focused on differentially expressed circRNAs and their function in this malignancy indicating that circRNAs may act as potentially novel biomarkers or therapeutic agents in this cancer type. 198 Increasing number of circRNAs have been reported to be involved in the progression and tumorigenesis of ovarian cancer. One study revealed that circPUM1 promoted cell proliferation, migration, invasion, and metastasis through increased the expression of nuclear factor kappa B (NF-κB) and matrix metallopeptidase 2 (MMP2) by sponging miR-615-5p and miR-6753-5p in ovarian cancer cells.…”

Section: Ovarian Cancermentioning

confidence: 99%

<p>Biological Roles and Mechanisms of Circular RNA in Human Cancers</p>

Tang

Hann

2020

OTT

136

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Circular RNA (circRNA) is an intriguing class of RNA with covalently closedloop structure and is highly stable and conservative. As new members of the ncRNAs, the function, mechanism, potential diagnostic biomarker, and therapeutic target have raised increased attention. Most circRNAs are presented with characteristics of abundance, stability, conservatism, and often exhibiting tissue/developmental-stage-specific manner. Over 30,000 circRNAs have been identified with their unique structures to maintain stability more easily than linear RNAs. An increased numbers of circRNAs are dysregulated and involved in several biological processes of malignance, such as tumorigenesis, growth, invasion, metastasis, apoptosis, and vascularization. Emerging evidence suggests that circRNAs play important roles by acting as miRNA sponge or protein scaffolding, autophagy regulators, and interacting with RNA-binding protein (RBP), which may potentially serve as a novel promising biomarker for prevention, diagnosis and therapeutic target for treatment of human cancer with great significance either in scientific research or clinic arena. This review introduces concept, major features of circRNAs, and mainly describes the major biological functions and clinical relevance of circRNAs, as well as expressions and regulatory mechanisms in various types of human cancer, including pathogenesis, mode of action, potential target, signaling regulatory pathways, drug resistance, and therapeutic biomarkers. All of which provide evidence for the potential utilities of circRNAs in the diagnosis and treatment of cancer.

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“…Cancer is still one of the increasing challenges worldwide (Shabaninejad et al, 2019; Tamtaji et al, 2020). The field of cancer therapy has undergone a number of changes.…”

Section: Anti‐tumor Activity Of Curcuminmentioning

confidence: 99%

Versatile role of curcumin and its derivatives in lung cancer therapy

Ashrafizadeh

Najafi

Makvandi

et al. 2020

Journal Cellular Physiology

104

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Lung cancer is a main cause of death all over the world with a high incidence rate. Metastasis into neighboring and distant tissues as well as resistance of cancer cells to chemotherapy demand novel strategies in lung cancer therapy. Curcumin is a naturally occurring nutraceutical compound derived from Curcuma longa (turmeric) that has great pharmacological effects, such as anti‐inflammatory, neuroprotective, and antidiabetic. The excellent antitumor activity of curcumin has led to its extensive application in the treatment of various cancers. In the present review, we describe the antitumor activity of curcumin against lung cancer. Curcumin affects different molecular pathways such as vascular endothelial growth factors, nuclear factor‐κB (NF‐κB), mammalian target of rapamycin, PI3/Akt, microRNAs, and long noncoding RNAs in treatment of lung cancer. Curcumin also can induce autophagy, apoptosis, and cell cycle arrest to reduce the viability and proliferation of lung cancer cells. Notably, curcumin supplementation sensitizes cancer cells to chemotherapy and enhances chemotherapy‐mediated apoptosis. Curcumin can elevate the efficacy of radiotherapy in lung cancer therapy by targeting various signaling pathways, such as epidermal growth factor receptor and NF‐κB. Curcumin‐loaded nanocarriers enhance the bioavailability, cellular uptake, and antitumor activity of curcumin. The aforementioned effects are comprehensively discussed in the current review to further direct studies for applying curcumin in lung cancer therapy.

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Circular RNAs in cancer: new insights into functions and implications in ovarian cancer

Cited by 115 publications

References 102 publications

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

<p>Biological Roles and Mechanisms of Circular RNA in Human Cancers</p>

Versatile role of curcumin and its derivatives in lung cancer therapy

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