Circular RNAs in Cardiovascular Diseases: Regulation and Therapeutic Applications

Wang, Lijun; Xu, Gui-e; Spanos, Michail; Li, Guoping; Lei, Zhiyong; Sluijter, Joost P.G.; Xiao, Junjie

doi:10.34133/research.0038

Cited by 11 publications

(6 citation statements)

References 147 publications

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“…circRNA is formed when a downstream 5’ splice site (splice donor) in a pre-mRNA molecule joins with an upstream 3’ splice site (splice acceptor) in the same molecule through a noncanonical splicing event. This results in the formation of a covalently closed loop structure 80 , 82 , 83 . In the case of circSKA3, it would be generated from the SKA3 pre-mRNA, where specific exons or introns are back-spliced together to form the circular structure.…”

Section: Role Of Circska3 In Human Cancermentioning

confidence: 99%

SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications – review article

Feng,

Wang,

Xiao

et al. 2024

International Journal of Surgery

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Spindle and kinetochore-associated complex subunit 3 (SKA3) is a microtubule-binding subcomplex of the outer kinetochore which plays a vital role in proper chromosomal segregation and cell division. Recently, SKA3 have been demonstrated its oncogenic role of tumorigenesis and development in cancers. In this review, we comprehensively deciphered SKA3 in human cancer from various aspects, including bibliometrics, pan-cancer analysis and narrative summary. We also provided top 10 predicted drugs targeting SKA3. We proposed that SKA3 was a potential target and brought new therapeutic opportunities for cancer patients.

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Section: Role Of Circska3 In Human Cancermentioning

confidence: 99%

SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications – review article

Feng,

Wang,

Xiao

et al. 2024

International Journal of Surgery

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“…The use of circRNAs as therapeutic targets in CAD has been widely discussed [ 24 , 29 , 170 ]. An attractive therapy strategy is the creation and use of artificial circRNAs in the form of miRNA sponges [ 171 ].…”

Section: Circrnas Are Promising Biomarkers and Therapeutic Targets Fo...mentioning

confidence: 99%

“…An attractive therapy strategy is the creation and use of artificial circRNAs in the form of miRNA sponges [ 171 ]. The advantages and disadvantages of the methodology of circRNA synthesis in vitro have been thoroughly reviewed recently [ 170 ]. The use of newly synthesized circRNAs is restricted by imperfect cyclization, the presence of extraneous fragments, their off-target effects, and the activation of the immune response.…”

Section: Circrnas Are Promising Biomarkers and Therapeutic Targets Fo...mentioning

confidence: 99%

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Circular RNAs Variously Participate in Coronary Atherogenesis

Dergunova,

Vinogradina,

Filippenkov

et al. 2023

CIMB

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Over the past decade, numerous studies have shown that circular RNAs (circRNAs) play a significant role in coronary artery atherogenesis and other cardiovascular diseases. They belong to the class of non-coding RNAs and arise as a result of non-canonical splicing of premature RNA, which results in the formation of closed single-stranded circRNA molecules that lack 5′-end caps and 3′-end poly(A) tails. circRNAs have broad post-transcriptional regulatory activity. Acting as a sponge for miRNAs, circRNAs compete with mRNAs for binding to miRNAs, acting as competing endogenous RNAs. Numerous circRNAs are involved in the circRNA–miRNA–mRNA regulatory axes associated with the pathogenesis of cardiomyopathy, chronic heart failure, hypertension, atherosclerosis, and coronary artery disease. Recent studies have shown that сirc_0001445, circ_0000345, circ_0093887, сircSmoc1-2, and circ_0003423 are involved in the pathogenesis of coronary artery disease (CAD) with an atheroprotective effect, while circ_0002984, circ_0029589, circ_0124644, circ_0091822, and circ_0050486 possess a proatherogenic effect. With their high resistance to endonucleases, circRNAs are promising diagnostic biomarkers and therapeutic targets. This review aims to provide updated information on the involvement of atherogenesis-related circRNAs in the pathogenesis of CAD. We also discuss the main modern approaches to detecting and studying circRNA–miRNA–mRNA interactions, as well as the prospects for using circRNAs as biomarkers and therapeutic targets for the treatment of cardiovascular diseases.

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“…For example, cir-znf215 has been found to promote the growth and metastasis of cholangiocarcinoma by inhibiting the AKT pathway ( Liao et al, 2023 ). circRNAs also exhibit tissue- and cell-specific expression ( Wang et al, 2023 ). Therefore, circRNAs could potentially serve as diagnostic and prognostic markers as well as therapeutic targets for PCa.…”

Section: Type and Role Of Wnt Signaling Pathway-related Ncrnas In Pca...mentioning

confidence: 99%

Unlocking the role of non-coding RNAs in prostate cancer progression: exploring the interplay with the Wnt signaling pathway

Bu,

Li,

Tian

2023

Front. Pharmacol.

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Prostate cancer (PCa) is one of the most common cancers in males, exhibiting a wide spectrum of clinical manifestations that pose challenges in its diagnosis and treatment. The Wnt signaling pathway, a conserved and complex pathway, is crucial for embryonic development, tissue homeostasis, and various physiological processes. Apart from the classical Wnt/β-catenin signaling pathway, there exist multiple non-classical Wnt signaling pathways, including the Wnt/PCP and Wnt/Ca2+ pathways. Non-coding RNAs (ncRNAs) are involved in the occurrence and development of PCa and the response to PCa treatment. ncRNAs are known to execute diverse regulatory roles in cellular processes, despite their inability to encode proteins. Among them, microRNAs, long non-coding RNAs, and circular RNAs play key roles in the regulation of the Wnt signaling pathway in PCa. Aberrant expression of these ncRNAs and dysregulation of the Wnt signaling pathway are one of the causes of cell proliferation, apoptosis, invasion, migration, and angiogenesis in PCa. Moreover, these ncRNAs affect the characteristics of PCa cells and hold promise as diagnostic and prognostic biomarkers. Herein, we summarize the role of ncRNAs in the regulation of the Wnt signaling pathway during the development of PCa. Additionally, we present an overview of the current progress in research on the correlation between these molecules and clinical features of the disease to provide novel insights and strategies for the treatment of PCa.

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Circular RNAs in Cardiovascular Diseases: Regulation and Therapeutic Applications

Cited by 11 publications

References 147 publications

SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications – review article

SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications – review article

Circular RNAs Variously Participate in Coronary Atherogenesis

Unlocking the role of non-coding RNAs in prostate cancer progression: exploring the interplay with the Wnt signaling pathway

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