Circular RNAs in organ injury: recent development

Wong, Ryan; Zhang, Yiwen; Zhao, Hailin; Ma, Ding

doi:10.1186/s12967-022-03725-9

Cited by 4 publications

(2 citation statements)

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“…Considering their function as miRNA sponges, protein decoys, and transcription regulators, circRNAs might have different biological roles that still need more investigations to be entirely detected. Consequently, the circRNAs precise therapeutic ability remains blurred until we gain a more profound understanding of the underlying intracellular interactions ( 192 ) and their feasibility as therapeutic targets ( 192 ). It should not be dismissed that the relatively long half-life of circRNAs due to their covalently enclosed-loop structure, potentiate them as powerful therapeutic agents ( 193 ).…”

Section: Future Perspectives and Probable Clinical Applications Of No...mentioning

confidence: 99%

The role of non-protein-coding RNAs in ischemic acute kidney injury

Sabet Sarvestani,

Afshari,

Azarpira

2024

Front. Immunol.

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Acute kidney injury (AKI) is a condition characterized by a rapid decline in kidney function within a span of 48 hours. It is influenced by various factors including inflammation, oxidative stress, excessive calcium levels within cells, activation of the renin-angiotensin system, and dysfunction in microcirculation. Ischemia-reperfusion injury (IRI) is recognized as a major cause of AKI; however, the precise mechanisms behind this process are not yet fully understood and effective treatments are still needed. To enhance the accuracy of diagnosing AKI during its early stages, the utilization of innovative markers is crucial. Numerous studies suggest that certain noncoding RNAs (ncRNAs), such as long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), play a central role in regulating gene expression and protein synthesis. These ncRNAs are closely associated with the development and recovery of AKI and have been detected in both kidney tissue and bodily fluids. Furthermore, specific ncRNAs may serve as diagnostic markers and potential targets for therapeutic interventions in AKI. This review aims to summarize the functional roles and changes observed in noncoding RNAs during ischemic AKI, as well as explore their therapeutic potential.

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Section: Future Perspectives and Probable Clinical Applications Of No...mentioning

confidence: 99%

The role of non-protein-coding RNAs in ischemic acute kidney injury

Sabet Sarvestani,

Afshari,

Azarpira

2024

Front. Immunol.

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“…In the recent years, circular RNA has been shown to be involved in mediating diverse process in organ injury [16,17] . CircRNAs are involved in the progression of multiple cancers [16,18,19] .…”

Section: Introductionmentioning

confidence: 99%

CircAkt3 participates in bone cancer pain progression in rats by modulating MAPK signalling pathway

Chen

Zhang

Shi

et al. 2023

Preprint

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Background: Cancer-induced bone paincaused by advanced tumor bone metastasis remains a clinical challenge, and the underlying mechanisms of BCP remain unknown. This study aimed to screen the expression profile of circular RNAs in a BCP rat model and provide a new theoretical basis for the role of circular RNA in the occurrence and development of BCP. Methods: We established a BCP rat model. The top four differentially expressed circRNAs (DECs) in the model were validated by agarose gel electrophoresis and Sanger sequencing between the BCP group and sham group. A circRNA-miRNA-mRNA network was constructed based on the interactions among circRNAs, microRNA (miRNA), and mRNA, which were predicted by TargetScan. mRNA and circRNA expression levels were detected by quantitative RT-PCR. In addition, Western Blot was performed to identify the protein levels of p-ERK, ERK, and Col8a1. Results: CircRNA parent genes were mainly enriched in MAPK and neurodevelopmental signalling pathways. CircAkt3 and circMap4k1 were significantly up-regulated in the BCP group. CircaAkt3 may increase p-ERK expression by upregulating Col8a1, which may further activate the MAPK pathway. Conclusions: The circAkt3 pathway may influence the development of bone cancer pain by activating the MAPK signaling pathway. This study provided important targets for the development of therapeutic strategy against BCP.

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