Circular RNAs in the tumour microenvironment

Ma, Zhonghua; Shuai, You; Gao, Xiangyu; Xi, Wen; Ji, Jiafu

doi:10.1186/s12943-019-1113-0

Cited by 73 publications

(49 citation statements)

References 171 publications

(292 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During invasion and intravasation, tumor cells should avoid immune recognition in order to survive before extravasating. Some reviews have elaborately summarized the association among circRNAs TME immune cells and the immune escape [8,9]. Herein, we focus on the crosstalk between circRNAs and immune cell function in relation to invasion.…”

Section: Immune Escapementioning

confidence: 99%

See 1 more Smart Citation

The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis

Shao

Lü

2020

Cancer Cell Int

View full text Add to dashboard Cite

Background Carcinomas are highly heterogeneous with regard to various cancer cells within a tumor microenvironment (TME), which is composed of stromal cells, blood vessels, immunocytes, and modified extracellular matrix. Focus of the study Circular RNAs (circRNAs) are non-coding RNAs that are expressed in cancer and stromal cells. They are closely associated with cancer metastasis as their expression in tumor cells directs the latter to migrate to different organs. circRNAs packaged in exosomes might be involved in this process. This is particularly important as the TME acts in tandem with cancer cells to enhance their proliferation and metastatic capability. In this review, we focus on recent studies on the crosstalk between circRNAs and the TME during cancer metastasis. Conclusion We particularly emphasize the roles of the interaction between circRNAs and the TME in anoikis resistance, vessel co-option, and local circRNA expression in directing homing of exosome.

show abstract

Section: Immune Escapementioning

confidence: 99%

“…Cumulative evidence has shown that circRNAs are closely associated with cancer metastasis [ 5 – 7 ]. The interaction between circRNAs and the TME has significant clinical relevance to cancer therapy [ 8 , 9 ]. Therefore, in the current review, we focus on the crosstalk between circRNAs and the TME in cancer metastasis.…”

Section: Introductionmentioning

confidence: 99%

The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis

Shao

Lü

2020

Cancer Cell Int

View full text Add to dashboard Cite

show abstract

“…Recent studies have shown that TME played a vital role during OC progression [31][32][33]. Moreover, TME-related molecular markers can be used as predictors to precisely assess patients' immunotherapy response, thereby enhancing their clinical outcome [34][35][36]. However, immune infiltration and its molecular mechanisms have not been thoroughly explained in OC.…”

Section: Discussionmentioning

confidence: 99%

A nine-gene signature related to tumor microenvironment predicts overall survival with ovarian cancer

Ding

Dong

Wang

et al. 2020

Aging

View full text Add to dashboard Cite

Mounting evidence suggests that immune cell infiltration within the tumor microenvironment (TME) is a crucial regulator of carcinogenesis and therapeutic efficacy in ovarian cancer (OC). In this study, 593 OC patients from TCGA were divided into high and low score groups based on their immune/stromal scores resulting from analysis utilizing the ESTIMATE algorithm. Differential expression analysis revealed 294 intersecting genes that influencing both the immune and stromal scores. Further Cox regression analysis identified 34 differentially expressed genes (DEGs) as prognostic-related genes. Finally, the nine-gene signature was derived from the prognostic-related genes using a Least Absolute Shrinkage and Selection Operator (LASSO) and Cox regression. This nine-gene signature could effectively distinguish the high-risk patients in the training (TCGA database) and validation (GSE17260) cohorts (all p < 0.01). A time-dependent receiver operating characteristic (ROC) analysis showed that the nine-gene signature had a reasonable predictive accuracy (AUC = 0.707, AUC =0.696) in both cohorts. In addition, this nine-gene signature is associated with immune infiltration in TME by Gene Set Variation Analysis (GSVA), and can be used to predict the survival of patients with OC.

show abstract

“…Up to now, several important pathways regulated by circRNAs have been reported in cancer progression, such as Wnt signaling pathway [27], MAPK signaling pathway [28], p-CDK2 pathway and NF-kappa B signaling pathway [29]. However, it is still unexplored how circular RNAs regulate steatotic IRI, and it is plausible that some specific signaling pathways dominate this process, which needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of circRNAs from steatotic livers after ischemia and reperfusion injury by next generation RNA sequencing

Zheng

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Global organ shortage has enabled the permission of fatty livers for transplantation purpose, taking the risk of graft dysfunction related to the rapider ischemia/reperfusion injury (IRI) progress. Increasing evidence supports the role of circular RNAs as essential regulators of this progress. However, data about circular RNAs in ischemia and reperfusion injured steatotic livers are practically nonexistent. Methods In the present study, high-fat diet (HFD)-fed mice model was used to generate hepatic steatosis mice. RNA-sequencing was performed on IRI model or sham liver tissues both in HFD-fed mice to screen the significant differentially expressed circular RNAs. GO and KEGG analysis were applied to figure out the potential function of these screened circular RNAs. Results From this, we successfully found the expression of some circular RNAs were significantly altered in IRI livers after HFD-fed mouse models. To further validate sequencing data, one up-regulated circRNA and four down-regulated circular RNAs were examined in steatotic mice livers after IRI. The RNase R digestion experiment exhibited these circRNAs possessed high stability compared with linear RNAs and sequence alignment of their junction positions provided identical sequences by sanger sequencing following gel electrophoresis, demonstrating the circularity of these circular RNAs. The expression of four stable circRNAs undigested by RNase R were further validated by quantitative PCR. Conclusion In summary, this study reveals that circular RNAs emerge as novel and potentially efficient targets which involve in more severe damage of steatotic livers to IRI.

show abstract

Circular RNAs in the tumour microenvironment

Cited by 73 publications

References 171 publications

The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis

The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis

A nine-gene signature related to tumor microenvironment predicts overall survival with ovarian cancer

Comprehensive analysis of circRNAs from steatotic livers after ischemia and reperfusion injury by next generation RNA sequencing

Contact Info

Product

Resources

About