Circular RNAs in tuberculosis and lung cancer

Jabeen, Sadia; Ahmed, Niaz; Rashid, Faiqa; Lal, Nand; Kong, Fanhui; Fu, Yingmei; Zhang, Fengmin

doi:10.1016/j.cca.2024.119810

Clinica Chimica Acta

2024

DOI: 10.1016/j.cca.2024.119810

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Circular RNAs in tuberculosis and lung cancer

Sadia Jabeen,

Niaz Ahmed,

Faiqa Rashid

et al.

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Cited by 1 publication

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Therapeutic Significance of NLRP3 Inflammasome in Cancer: Friend or Foe?

Jalali,

Mitchell,

Pompoco

et al. 2024

IJMS

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Besides various infectious and inflammatory complications, recent studies also indicated the significance of NLRP3 inflammasome in cancer progression and therapy. NLRP3-mediated immune response and pyroptosis could be helpful or harmful in the progression of cancer, and also depend on the nature of the tumor microenvironment. The activation of NLRP3 inflammasome could increase immune surveillance and the efficacy of immunotherapy. It can also lead to the removal of tumor cells by the recruitment of phagocytic macrophages, T-lymphocytes, and other immune cells to the tumor site. On the other hand, NLRP3 activation can also be harmful, as chronic inflammation driven by NLRP3 supports tumor progression by creating an environment that facilitates cancer cell proliferation, migration, invasion, and metastasis. The release of pro-inflammatory cytokines such as IL-1β and IL-18 can promote tumor growth and angiogenesis, while sustained inflammation may lead to immune suppression, hindering effective anti-tumor responses. In this review article, we discuss the role of NLRP3 inflammasome-mediated inflammatory response in the pathophysiology of various cancer types; understanding this role is essential for the development of innovative therapeutic strategies for cancer growth and spread.

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Therapeutic Significance of NLRP3 Inflammasome in Cancer: Friend or Foe?

Jalali,

Mitchell,

Pompoco

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Circular RNAs in tuberculosis and lung cancer

Cited by 1 publication

References 113 publications

Therapeutic Significance of NLRP3 Inflammasome in Cancer: Friend or Foe?

Therapeutic Significance of NLRP3 Inflammasome in Cancer: Friend or Foe?

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