Circularly Polarized Luminescence of Achiral Cyanine Molecules Assembled on DNA Templates

Abstract

The exploration of biocompatible materials with circularly polarized luminescence (CPL) activity is becoming an attractive topic due to the great potential application in biosensing and bioimaging. Here, we describe a strategy to fabricate new CPL-active biomaterials using achiral carbazole-based biscyanine fluorophores coassembled with chiral deoxyribonucleic acid (DNA) molecules. This cyanine molecule has been shown to behave as a DNA detecting probe, featuring strong fluorescent emission induced by restriction of intramolecular rotation (RIR). When the achiral cyanine molecules are bound to the minor groove of DNA via electrostatic attraction in aqueous solution, the chirality of the DNA molecules can be transferred to the confined RIR cyanine dyes, triggering a remarkable circularly polarized luminescent emission. The chirality of the CPL signal can be regulated by the structures of the DNA templates. Stimuli-responsive CPL activates were observed from DNA–cyanine complexes. We further verified this strategy on different DNA-based nanomaterials, including DNA origami nanostructure. Our design presents a new avenue to fabricate compatible CPL materials.

Finely Controlled Circularly Polarized Luminescence of a Mechano‐Responsive Supramolecular Polymer

“…Circularly polarized luminescence (CPL) is au nique chiroptical property of chiral emission systems and is regarded as one of the most important tools for investigating the excitedstate properties of chiral materials. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Materials exhibiting CPL are of great interest not only for understanding the mystery of chirality but also for potential important applications,s uch as chiroptical recognition sensors, [8,9] noninvasive biomedical diagnosis in the biological field, [10][11][12][13] and catalysts for asymmetric chemical synthesis. [14,15] Mechano-responsive materials also usually exhibit emission properties under mechanical stress.…”

Emerging Cubic Chirality in γCD‐MOF for Fabricating Circularly Polarized Luminescent Crystalline Materials and the Size Effect

“…The aggregation induced CPL (AICPL) of the AIEgens has been well investigated. However, the CPL of segregated AIEgens was rarely reported . Herein, the large AIEgen, TCBPE, was encapsulated into γCD‐MOF (Figure a; Supporting Information, Figures S12–S14).…”

Finely Controlled Circularly Polarized Luminescence of a Mechano‐Responsive Supramolecular Polymer

“…Circularly polarized luminescence (CPL) is a unique chiroptical property of chiral emission systems and is regarded as one of the most important tools for investigating the excited‐state properties of chiral materials . Materials exhibiting CPL are of great interest not only for understanding the mystery of chirality but also for potential important applications, such as chiroptical recognition sensors, noninvasive biomedical diagnosis in the biological field, and catalysts for asymmetric chemical synthesis …”