Circulating adipokines are associated with pre-eclampsia in women with type 1 diabetes

Kelly, Clare B.; Hookham, Michelle B.; Yu, Yongxin; Lockhart, Samuel; Du, Mei; Jenkins, Alicia J.; Nankervis, Alison; Hanssen, Kristian F.; Henriksen, Tore; Garg, Satish K.; Hammad, Samar M.; Scardo, James A.; Aston, Christopher E.; Patterson, Christopher; Lyons, Timothy J.

doi:10.1007/s00125-017-4415-z

Cited by 21 publications

(24 citation statements)

References 58 publications

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“…Several previous studies revealed direct associations between the circulating FABP4 and leptin [32,33,46,47]. These relationships can be explained by the fact that both leptin and FABP4 are mainly secreted by the adipose tissue [48].…”

Section: Discussionmentioning

confidence: 99%

FABP4 in Gestational Diabetes—Association between Mothers and Offspring

Patro-Małysza

Trojnar

Kimber-Trojnar

et al. 2019

JCM

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Fetuses exposed to gestational diabetes mellitus (GDM) have a higher risk of abnormal glucose homeostasis in later life. The molecular mechanisms of this phenomenon are still not fully understood. Fatty acid binding protein 4 (FABP4) appears to be one of the most probable candidates involved in the pathophysiology of GDM. The main aim of the study was to investigate whether umbilical cord serum FABP4 concentrations are altered in term neonates born to GDM mothers. Two groups of subjects were selected—28 healthy controls and 26 patients with GDM. FABP4, leptin, and ghrelin concentrations in the umbilical cord serum, maternal serum, and maternal urine were determined via an enzyme-linked immunosorbent assay. The umbilical cord serum FABP4 levels were higher in the GDM offspring and were directly associated with the maternal serum FABP4 and leptin levels, as well as the prepregnancy body mass index (BMI) and the BMI at and after delivery; however, they correlated negatively with birth weight and lipid parameters. In the multiple linear regression models, the umbilical cord serum FABP4 concentrations depended positively on the maternal serum FABP4 and negatively on the umbilical cord serum ghrelin levels and the high-density lipoprotein cholesterol. There are many maternal variables that can affect the level of FABP4 in the umbilical cord serum, thus, their evaluation requires further investigation.

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Section: Discussionmentioning

confidence: 99%

FABP4 in Gestational Diabetes—Association between Mothers and Offspring

Patro-Małysza

Trojnar

Kimber-Trojnar

et al. 2019

JCM

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“…One review concluded that the presence of gestational diabetes can diminish the effectiveness of antenatal VAS, and that the altered metabolic state can cause increases in VA intake to lead to hepatic toxicity ( 91 ). Among diabetic pregnancies, the adipokine RBP does not have a statistically significant association with the occurrence of PE ( 92 ). Other studies have investigated the association between higher RBP concentrations and the risk of gestational diabetes, finding both positive ( 93–96 ) and negative associations ( 97 ).…”

Section: Resultsmentioning

confidence: 92%

Vitamin A Requirements in Pregnancy and Lactation

Gannon

Jones

Mehta

2020

Current Developments in Nutrition

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Pregnancy and lactation are critical life stages with unique nutritional requirements, including for vitamin A (VA). Current Dietary Reference Intakes (DRIs) for VA were published in 2001. The objective of this review was to identify and categorize evidence related to VA requirements in pregnancy and lactation since these DRIs were formulated. We searched MEDLINE and included articles according to an analytic framework of maternal VA exposure on status and health outcomes in the mother-child dyad. Intermediate and indirect evidence supports that maternal VA intakes can impact the mother's VA status, breastmilk, and health outcomes, as well as the child's VA status and select health outcomes. Food-based approaches may lead to more sustained, sufficient VA status in mothers and children. Research needs include further study linking maternal VA intakes on maternal and child VA status, and further associations with outcomes to determine intake requirements to optimize health.

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“…Participants in the current study are a subset of the “Markers and Mechanisms for PreEclampsia in Type 1 Diabetes” (MAMPED) cohort. The MAMPED design, participant characteristics, and inclusion/exclusion criteria have been described previously [ 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. The overall goal of MAMPED was to identify early markers and potential mechanisms for PE in the context of pregnancy complicated by maternal T1DM.…”

Section: Methodsmentioning

confidence: 99%

Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes

et al. 2020

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The risk for preeclampsia (PE) is enhanced ~4-fold by the presence of maternal type 1 diabetes (T1DM). Vitamin D is essential for healthy pregnancy. We assessed the total, bioavailable, and free concentrations of plasma 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and vitamin D binding protein (VDBP) at ~12, ~22, and ~32 weeks’ gestation (“Visits” (V) 1, 2, and 3, respectively) in 23 T1DM women who developed PE, 24 who remained normotensive, and 19 non-diabetic, normotensive women (reference controls). 25(OH)D deficiency was more frequent in diabetic than non-diabetic women (69% vs. 22%, p < 0.05), but no measure of 25(OH)D predicted PE. By contrast, higher 1,25(OH)2D concentrations at V2 (total, bioavailable, and free: p < 0.01) and V3 (bioavailable: p < 0.05; free: p < 0.01), lower concentrations of VDBP at V3 (p < 0.05), and elevated ratios of 1,25(OH)2D/VDBP (V2, V3: p < 0.01) and 1,25(OH)2D/25(OH)D (V3, p < 0.05) were all associated with PE, and significance persisted in multivariate analyses. In summary, in women with T1DM, concentrations of 1,25(OH)2D were higher, and VDBP lower, in the second and third trimesters in women who later developed PE than in those who did not. 1,25(OH)2D may serve as a new marker for PE risk and could be implicated in pathogenesis.

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Circulating adipokines are associated with pre-eclampsia in women with type 1 diabetes

Cited by 21 publications

References 58 publications

FABP4 in Gestational Diabetes—Association between Mothers and Offspring

FABP4 in Gestational Diabetes—Association between Mothers and Offspring

Vitamin A Requirements in Pregnancy and Lactation

Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes

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