Circulating adiponectin and visfatin levels in rheumatoid arthritis and their correlation with disease activity: A meta‐analysis

Lee, Young Ho; Bae, Sang Cheol

doi:10.1111/1756-185x.13038

Cited by 83 publications

(92 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In vivo studies on APN KO mice confirmed that Adiponectin has immunosuppressive effects since these animals present an increase of anti-inflammatory cells and mediators as well as an alteration of M1 (increased TNF-α, and IL-6), and M2 markers, (decreased IL-10) (Ohashi et al, 2010). Finally, human studies have demonstrated a strong modulation of Adiponectin serum concentrations and its receptors in course of immune disorders, powerfully suggesting that Adiponectin has an active role in regulating immune responses (Çoban et al, 2017;Dini et al, 2017;Pecoraro et al, 2017;Lee and Bae, 2018;Polito et al, 2019). Furthermore, it is able to acts also in oxidative stress, indeed Adiponectin in a cancer cells model induces apoptosis and reduce proliferation by oxidative stress in a time-and dose-dependent manner (Van Brocklyn and Williams, 2012).…”

Section: Adiponectin Functionsmentioning

confidence: 74%

The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity

et al. 2020

View full text Add to dashboard Cite

Exercise represents the most important integrative therapy in metabolic, immunologic and chronic diseases; it represents a valid strategy in the non-pharmacological intervention of lifestyle linked diseases. A large body of evidence indicates physical exercise as an effective measure against chronic non-communicable diseases. The worldwide general evidence for health benefits are both for all ages and skill levels. In a dysregulated lifestyle such as in the obesity, there is an imbalance in the production of different cytokines. In particular, we focused on Adiponectin, an adipokine producted by adipose tissue, and on Orexin-A, a neuropeptide synthesized in the lateral hypothalamus. The production of both Adiponectin and Orexin-A increases following regular and structured physical activity and both these hormones have similar actions. Indeed, they improve energy and glucose metabolism, and also modulate energy expenditure and thermogenesis. In addition, a relevant biological role of Adiponectin and Orexin A has been recently highlighted in the immune system, where they function as immune-suppressor factors. The strong connection between these two cytokines and healthy status is mediated by physical activity and candidates these hormones as potential biomarkers of the beneficial effects induced by physical activity. For these reasons, this review aims to underly the interconnections among Adiponectin, Orexin-A, physical activity and healthy status. Furthermore, it is analyzed the involvement of Adiponectin and Orexin-A in physical activity as physiological factors improving healthy status through physical exercise.

show abstract

Section: Adiponectin Functionsmentioning

confidence: 74%

The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A large number of observational epidemiological studies have been undertaken to investigate the role of adipokines in the occurrence and progression of RA. Two recent meta-analyses of case-control studies demonstrated that circulating adiponectin levels could be signi cantly higher in the RA patients than those in the health controls [30,31]. However, it was also reported separately that adiponectin levels were not related to RA activity [30,32].…”

Section: Discussionmentioning

confidence: 99%

“…Two recent meta-analyses of case-control studies demonstrated that circulating adiponectin levels could be signi cantly higher in the RA patients than those in the health controls [30,31]. However, it was also reported separately that adiponectin levels were not related to RA activity [30,32]. Meanwhile, the ndings from meta-analyses consistently indicated that patients with RA may have higher circulating leptin levels compared with the control group [33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Adipokines and risk of rheumatoid arthritis: a Mendelian randomization study

Zhu

Zheng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Circulating adipokines levels have been reported to be associated with the risk of rheumatoid arthritis (RA). However, it is still unclear whether these associations are causal or biased by reverse causation or residual confounding. This study aimed to assess potential causal roles of five adipokines (namely, adiponectin, leptin, resistin, chemerin, and retinol-blinding protein 4 [RBP4]) in the occurrence of RA.Methods: We conducted a two-sample Mendelian randomization analysis to investigate these associations. We used summary-level data from genome-wide association studies (GWASs) for adipokines in individuals of European ancestry as the exposure, and a separate large-scale meta-analysis of a GWAS which included 14,361 RA cases and 43,923 controls of European ancestry as the outcome. Genetic variants were selected as instrumental variables if robustly genome-wide significant in their associations with adipokines. The causal effects were estimated using the inverse-variance weighted method in the primary analysis. Sensitivity analyses were performed to warrant that bias due to genetic pleiotropy was unlikely.Results: The circulating resistin was found to be the only adipokinetic factor having statistical significance, with higher levels causally associated with the risk of RA (odds ratio: 1.28; 95% confidence interval: [1.07, 1.53] per unit increase in the natural log-transformed resistin). In contrast, associations of adiponectin, leptin, chemerin, and RBP4 with risk of RA were not statistically significant. The MR assumptions did not seem to be violated. Sensitivity analyses yielded consistent findings.Conclusions: Genetically predicted circulating resistin levels were positively associated with RA risk. Our analysis suggested that resistin may play a notable causal role in RA pathogenesis. It would be beneficial for the development of clinical as well as public health strategies that target appropriate levels of resistin for future RA intervention.

show abstract

“…The mechanism of adipokines induced-ADAMTS gene expression in chondrocytes and chondrosarcoma was demonstrated before by our group (21-23). An up-regulated adiponectin level in both RA and OA patients was reported (24,25). After these fi ndings, the researchers have focused on the mechanism of adiponectin caused joint destruction.…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent effects of adiponectin on ADAMTS-9 gene expression in human chondrocytes

Yaykaşlı¹,

Hatipoğlu²,

Yaykaşlı³

et al. 2017

BLL

View full text Add to dashboard Cite

OBJECTIVE: A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), comprising of 19 members is a family of peptidases. They have several vital functions in physiological and pathological processes in organisms. ADAMTS-9 has aggrecanolytic activity and is responsible for degradation of aggrecan mainly in articular cartilage. It is known that adiponectin is the most abundantly secreted adipokine (adipocytokines), and the characteristics of adiponectin have not been elucidated yet. It was assumed that adiponectin has antiinfl ammatory effect before. However, an infl ammatory feature of adiponectin was shown in researches. In our study, the effect of adiponectin on ADAMTS-9 gene expression in primary human chondrocytes was investigated. METHODS: Primary human chondrocytes were exposed to adiponectin at 1, 4, 8 and 12 μg/ml doses for certain time period. Total RNA was isolated and reverse-transcribed by random primer after incubation. ADAMTS-9 and β-actin genes expression levels were determined using real-time polymerase chain reaction (qRT-PCR). RESULTS: The highest upregulation of ADAMTS-9 gene expression level was found at 12 μg/ml dose of adiponectin and 48 h incubation. CONCLUSION: Adiponectin is the key element in the maintenance of cartilage homeostasis. Similarly, the involvement of adiponectin in articular infl ammatory diseases was demonstrated in detail. These fi ndings bring adiponectin into central place in the research to develop adiponectin based new therapy methods for arthritic diseases. Together with these fi ndings, our results suggest that adiponectin may be involved in the degradation of articular cartilage by increasing ADAMTS-9 gene expression (Tab. 1, Fig. 3, Ref. 35). Text in PDF www.elis.sk.

show abstract

Circulating adiponectin and visfatin levels in rheumatoid arthritis and their correlation with disease activity: A meta‐analysis

Cited by 83 publications

References 36 publications

The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity

The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity

Adipokines and risk of rheumatoid arthritis: a Mendelian randomization study

Dose-dependent effects of adiponectin on ADAMTS-9 gene expression in human chondrocytes

Contact Info

Product

Resources

About