Circulating androgen levels are associated with subclinical atherosclerosis and arterial stiffness in healthy recently menopausal women

Creatsa, Maria; Armeni, Eleni; Stamatelopoulos, Kimon; Rizos, Demetrios; Georgiopoulos, Georgios; Kazani, Maria; Alexandrou, Andreas; Dendrinos, S.; Augoulea, Areti; Papamichael, Christos; Lambrinoudaki, Ιrene

doi:10.1016/j.metabol.2011.06.005

Cited by 82 publications

(47 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the study of Creatsa et al (38) on 120 healthy postmenopausal women, estradiol levels were not related to the aforementioned vascular parameters, whereas Ouyang et al (39) did not find a significant correlation of estradiol levels with common carotid IMT or coronary calcification. Similarly, in a subgroup of the Multi-Ethnic Study of Atherosclerosis (MESA) assessing 881 postmenopausal women, abdominal aortic calcification quantified by computerized tomography was unrelated to estrogen concentrations (40).…”

Section: Early Markers Of Atherosclerosismentioning

confidence: 89%

“…In the study of Jeon et al (45) on 436 postmenopausal women, higher estradiol levels were independently related to a lower probability of having coronary artery calcification. Concerning the evidence of endogenous androgens, in the study of Creatsa et al (38), FAI was positively associated with PWV independently of age, smoking, and BMI. These findings agree with those of the large cross-sectional MESA study, where testosterone was independently associated with common carotid IMT after correcting for age, BMI, and insulin resistance.…”

Section: Early Markers Of Atherosclerosismentioning

confidence: 94%

See 1 more Smart Citation

MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

Παππά

Alevizaki

2012

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Cardio-and cerebro-vascular diseases are two leading causes of death and long-term disability in postmenopausal women. The acute fall of estrogen in menopause is associated with increased cardiovascular risk. The relative contribution of androgen to this risk is also being recognized. The use of more sensitive assays for estradiol measurement and the study of receptor and carrier protein gene polymorphisms have provided some new information on the clinical relevance of endogenous sex steroids. We provide an update on the role of endogenous sex steroids on cardio-and cerebro-vascular disease in the postmenopausal period. Design and methods: We performed a PubMed search using the terms 'endogenous estrogen', 'androgen', 'cardiovascular disease', 'cerebro-vascular disease', 'stroke', 'carotid artery disease', and 'subclinical atherosclerosis'. Results: The majority of studies show a beneficial effect of endogenous estrogen on the vasculature; however, there are a few studies reporting the contrary. A significant body of literature has reported associations of endogenous estrogen and androgen with early markers of atherosclerosis and metabolic parameters. Data on the relevance of endogenous sex steroids in heart disease and stroke are inconclusive. Conclusions: Most studies support a beneficial role of endogenous estrogens and, probably, an adverse effect of androgens in the vasculature in postmenopausal women. However, the described associations may not always be considered as causal. It is possible that circulating estrogen might represent a marker of general health status or alternatively reflect the sum of endogenous androgens aromatized in the periphery. Elucidating the role of sex steroids in cardio-and cerebro-vascular disease remains an interesting field of future research.

show abstract

Section: Early Markers Of Atherosclerosismentioning

confidence: 89%

Section: Early Markers Of Atherosclerosismentioning

confidence: 94%

MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

Παππά

Alevizaki

2012

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…26) Niboshi et al showed that baPWV increases with age even in childhood and reported a higher baPWV in boys (1041 cm/sec) than in girls (952 cm/sec) aged 15-17 years. 18) Tomiyama et al examined 326 people aged 25-30 years and reported a baPWV of 1150 cm/sec in men and 990 cm/sec in women.…”

Section: Bapwv and Abimentioning

confidence: 99%

Ankle-Brachial Index, Toe-Brachial Index, and Pulse Volume Recording in Healthy Young Adults

Watanabe

Hara

Yunoki

et al. 2015

Annals of Vascular Diseases

View full text Add to dashboard Cite

Objective: To clarify the characteristics of ankle-brachial index (ABI), toe-brachial index (TBI), and pulse volume recording (PVR) of the ankle with brachial-ankle pulse wave velocity (baPWV) in healthy young adults. Material and Methods: We analyzed ABI, TBI, baPWV, and PVR in the ankle of healthy adults aged 20 to 25 years (median, 20 years) using an automatic oscillometric device between 2002 and 2013. The ABI, baPWV, and PVR in 1282 legs of 641 subjects (301 men and 340 women) and the TBI in 474 toes of 237 subjects (117 men and 120 women) were evaluated. Results:The measured values showed no bilateral differences. ABI and baPWV were higher in men than in women, but TBI was similar in both sexes. ABI <1.0 was observed in 18.1% of the legs in men and in 25.6% in women. TBI <0.7 was observed in 16.2% of the toes in men and 19.1% in women. For ankle PVR, the % mean arterial pressure was higher in women than in men. The upstroke time was <180 ms in most subjects. Conclusions: For young people, ABI <1.0 or TBI <0.7 may not always indicate vascular abnormalities. When evaluating circulatory indexes, age and sex should be considered.Keywords: ABI, TBI, baPWV, PVR, healthy young adults indications of ABI. The cut-off value of ABI for detecting PAD has been confirmed as 0.9 with high sensitivity and specificity. 2) Moreover, ABI is a strong predictor of cardiovascular events: the normal ABI range was revised as 1.00 to 1.40, because patients with ABI ranging from 0.91 to 0.99 have been shown to be at the borderline of cardiovascular risk. 2) On the other hand, TBI measurements are more cumbersome and are limited to special institutions (e.g., vascular laboratories) using different techniques including laser Doppler flowmetry, photoplethysmography, oscillometric plethysmography, and mercury strain gauge plethysmography. Thus, basic data on a uniform technique for a large population remain limited. Although the cut-off value of TBI for detecting PAD is set at 0.6 or 0.7, there has been no global consensus. 1,[3][4][5] Although the normal standard ranges of ABI and TBI are based on data obtained mostly from middle and senior adults, [3][4][5][6] young patients with lower limb complaints such as coldness, pain, or claudication are also primarily examined by ABI and TBI measurements because PAD including Buerger disease, Raynaud disease, Takayasu arteritis, and even arteriosclerotic diseases can occur in young patients, as the prevalence of PAD is estimated to be 1.2% to 4% of people in their late 20s. 7) However, they occasionally show ABI <1.0 or TBI <0.7 despite their normal physical findings, making the diagnosis confusing.The gold standard method for ABI measurement has been the Doppler method since the 1980s, 2) but on the other hand, automated oscillometric sphygmomanometers have come into use recently. Moreover, full-automated ABI/TBI measuring devices have been developed since the late 1990s. 8,9) We have used the automated ABI/TBI measuring devices in our clinical work. The form PWV/ABI ® (Colin Co., Aichi, Jap...

show abstract

“…In the present study, the average age of the female subjects was 65 years. Creatsa et al reported that, in postmenopausal women, a higher free androgen index, as one of the markers of circulating androgen, was associated with subclinical organ damage, 21 in the same way that carotid artery intima-media thickness and pulse wave velocity are markers of cardiovascular risk. 22, 23 Glisic et al reported that a higher free androgen index was associated with lower NT-proBNP in postmenopausal women.…”

Section: Bnp or Nt-probnp And Cardiovascular Eventsmentioning

confidence: 96%

Sex Differences in the Prognostic Power of Brain Natriuretic Peptide and N-Terminal Pro-Brain Natriuretic Peptide for Cardiovascular Events　― The Japan Morning Surge-Home Blood Pressure Study ―

Taki

Ishiyama

Mizuno

et al. 2018

Circ J

View full text Add to dashboard Cite

sex in heart failure populations, the results are conflicting. 13, 14 This may explain why data were unable to discriminate between BNP and NT-proBNP in heterogeneous heart failure populations, yielding inconsistent results.The aim of this study was therefore to investigate differences between BNP and NT-proBNP with regard to cardiovascular events and extend the search for this difference to sex, in a large clinical population with cardiovascular risk factors. Methods SubjectsWe used baseline data from the Japan Morning SurgeHome Blood Pressure (J-HOP) Study. The protocol of the J-HOP study has been published (Supplementary File 1). 15 Briefly, the J-HOP study is a prospective observational study (University Hospital Medical Information Network Clinical Trials Registry, UMIN000000894) evaluating the use of home blood pressure (BP) measurements to predict S erum levels of natriuretic peptide hormones, in particular brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP), are useful biomarkers for ruling out heart failure, 1-3 as well as strong prognostic markers for cardiovascular events in not only heart failure and hypertensive populations but also the general population. 4-6 BNP, in contrast to NT-proBNP, is biologically active when released into the circulation. 7, 8 In some studies comparing the utility of BNP and NT-proBNP for heart failure screening and prognostic value for cardiovascular events, no practical difference was observed. 3,9 The value of those studies, however, was limited by their evaluation of selected patients. One study involved a small sample of patients with suspected heart failure, 3 and another study was performed in a stable and symptomatic heart failure population. 9 In addition, both BNP and NT-proBNP are higher in women than in men. Background: Brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are prognostic biomarkers. Although these 2 peptides differ with regard to biological characteristics, there are few reports on the differences between BNP and NT-proBNP with regard to cardiovascular events or according to sex.

show abstract

Circulating androgen levels are associated with subclinical atherosclerosis and arterial stiffness in healthy recently menopausal women

Cited by 82 publications

References 59 publications

MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

Ankle-Brachial Index, Toe-Brachial Index, and Pulse Volume Recording in Healthy Young Adults

Sex Differences in the Prognostic Power of Brain Natriuretic Peptide and N-Terminal Pro-Brain Natriuretic Peptide for Cardiovascular Events　― The Japan Morning Surge-Home Blood Pressure Study ―

Contact Info

Product

Resources

About

Circulating androgen levels are associated with subclinical atherosclerosis and arterial stiffness in healthy recently menopausal women

Cited by 82 publications

References 59 publications

MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

MECHANISMS IN ENDOCRINOLOGY: Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period

Ankle-Brachial Index, Toe-Brachial Index, and Pulse Volume Recording in Healthy Young Adults

Sex Differences in the Prognostic Power of Brain Natriuretic Peptide and N-Terminal Pro-Brain Natriuretic Peptide for Cardiovascular Events ― The Japan Morning Surge-Home Blood Pressure Study ―

Contact Info

Product

Resources

About

Sex Differences in the Prognostic Power of Brain Natriuretic Peptide and N-Terminal Pro-Brain Natriuretic Peptide for Cardiovascular Events　― The Japan Morning Surge-Home Blood Pressure Study ―