Circulating angiogenic cell response to sprint interval and continuous exercise

O'Carroll, Louis; Wardrop, Bruce; Murphy, Ronan P.; Ross, Mark; Harrison, Michael

doi:10.1007/s00421-018-04065-7

Cited by 17 publications

(27 citation statements)

References 41 publications

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“…Comparing our findings of an increase in CAC numbers directly after an acute bout of exercise with existing literature, we find an agreement with previously published reports of CAC (Shill et al, 2016;O'Carroll et al, 2019), EPC (Bonsignore et al, 2010;Krüger et al, 2015;Montgomery et al, 2019), and HPC kinetics (Krüger et al, 2015;Baker et al, 2017). However, it is apparent that their definitions vary and especially for HPCs CD31-expression is usually not taken into account; Krüger et al (2015) found acute exercise to increase HPCs defined as CD34 + /CD45 + , while Baker et al (2017) defined them only as CD34 + and also found numbers to be increased after exercising at a high but not at a moderate intensity.…”

Section: Discussionsupporting

confidence: 93%

Acute Exercise-Induced Oxidative Stress Does Not Affect Immediate or Delayed Precursor Cell Mobilization in Healthy Young Males

et al. 2020

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Exercise is known to acutely and transiently mobilize precursor cells to the peripheral blood. To date, the underlying mechanisms have not yet been fully elucidated and we hypothesized that exercise-induced oxidative stress could be a mobilizing agent, either directly or via circulating apoptotic cells as mediators. The aim of the study was to assess the effect of acute exercise-induced oxidative stress on numbers of circulating angiogenic precursor cells (CACs), circulating non-angiogenic precursor cells (nCACs), mesenchymal precursor cells (MPCs), mature endothelial cells (ECs), and mononuclear cells (MNCs), as well as their apoptotic subsets. Healthy, young males (n = 18, age: 24.2 ± 3.5 years) completed two identical, standardized incremental cycling tests. The first, un-supplemented control test was followed by a 7-day-long supplementation of vitamin C (1,000 mg/day) and E (400 I.U./day), immediately preceding the second test. Blood samples were collected before, directly after, 30, 90, 180, and 270 min after exercise, and aforementioned circulating cell numbers were determined by flow cytometry and a hematology analyzer. Additionally, total oxidative capacity (TOC) and total antioxidative capacity (TAC) were measured in serum at all timepoints. Antioxidative supplementation abolished the exerciseinduced increase in the oxidative stress index (TOC/TAC), and reduced baseline concentrations of TOC and TOC/TAC. However, it did not have any effect on CACs, nCACs, and MPC numbers or the increase in apoptotic MNCs following exercise. Our results indicate that exercise-induced oxidative stress is neither a main driver of lymphocyte and monocyte apoptosis, nor one of the mechanisms involved in the immediate or delayed mobilization of precursor cells.

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Section: Discussionsupporting

confidence: 93%

Acute Exercise-Induced Oxidative Stress Does Not Affect Immediate or Delayed Precursor Cell Mobilization in Healthy Young Males

et al. 2020

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“…Our findings are also in contrast with O'Carroll and colleagues ( O'Carroll et al., 2019 ), who compared a 45-min bout of continuous exercise at 70% peak oxygen uptake with 6 × 20 s maximal sprints on a cycle ergometer on circulating lymphocyte counts. LY, CD8 + T, and CD4 + T cell counts were elevated following both trials.…”

Section: Discussioncontrasting

confidence: 99%

“…These increases were significantly higher following interval exercise compared to continuous exercise. This may be due to the higher exercise intensities implemented by O'Carroll et al., ( O'Carroll et al., 2019 ), whereby sprint intervals were ‘maximal effort’ and resulted in mean power outputs of 223 ± 6% of the power output at VO 2 peak. In the present study, power outputs corresponded to 130% peak power and 85% V̇O 2 max for SIE and MICE, respectively.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the lymphocyte response to interval exercise versus continuous exercise in recreationally trained men

Arroyo¹,

Tagesen²,

Hart³

et al. 2022

Brain, Behavior, & Immunity - Health

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The purpose of this investigation was to compare changes in circulating lymphocyte subset cell counts between high-intensity interval exercise (HIIE), sprint interval exercise (SIE), and moderate-intensity continuous exercise (MICE). Recreationally active men (n = 11; age: 23 ± 4 yr; height: 179.9 ± 4.5 cm; body mass: 79.8 ± 8.7 kg; body fat %:12.6 ± 3.8%; V̇O 2 max: 46.6 ± 3.9 ml⋅kg −1 ⋅min −1 ) completed a maximal graded exercise test to determine maximal oxygen uptake (V̇O 2 max) and three duration-matched cycling trials (HIIE, SIE, and MICE) in a randomized, counterbalanced fashion. HIIE consisted of fifteen 90-s bouts at 85% V̇O 2 max interspersed with 90-s active recovery periods. SIE consisted of fifteen 20-s bouts at 130% maximal power and 160-s active recovery periods. MICE was a continuous bout at 65% V̇O 2 max. Total exercise duration was 53 min in all three trials, including warm-up and cool-down. Blood was collected before, immediately post, 30 min, 2 h, 6 h, and 24 h post-exercise. Changes in lymphocyte subset counts, and surface expression of various markers were analyzed via flow cytometry. Changes were assessed using mixed model regression analysis with an autoregressive first order repeated measures correction. Significant decreases were observed in absolute counts of CD56 dim NK cells, CD19 + B cells, CD4 + T cells, and CD8 + T cells 30 min and 24-h post-exercise in all three trials. Despite resulting in greater total work and oxygen consumption, MICE elicited similar changes in lymphocyte subset counts and receptor expression compared to both SIE and HIIE. Similarly, while the two interval trials resulted in differing oxygen consumption and total work, no differences in the lymphocyte response were observed. Though both forms of exercise resulted in declines in circulating lymphocyte cell counts, neither exercise type provides an immune-related advantage when matched for duration.

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“…In the present analysis we could not confirm outcomes of single studies reporting differences in the mobilization of stem cells depending on subject-related variables such as age [10,67,73] or training status [40,46,53,60] nor on interventiondependent variables such as intensity [39,41,60,61,64,69], or modality [49]. Only the number of ESCs 12-48 h after exercise was affected with larger effect sizes when percentage of male subjects was greater and when duration or load was higher.…”

Section: Moderator Variablescontrasting

confidence: 73%

Changes in Circulating Stem and Progenitor Cell Numbers Following Acute Exercise in Healthy Human Subjects: a Systematic Review and Meta-analysis

Schmid

Kröpfl

Spengler

2021

Stem Cell Rev and Rep

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Despite of the increasing number of investigations on the effects of acute exercise on circulating stem and progenitor cell (SC) numbers, and in particular on respective subgroups, i.e. endothelial (ESC), hematopoietic (HSC), and mesenchymal (MSC) stem and progenitor cells, a consensus regarding mechanisms and extent of these effects is still missing. The aim of this meta-analysis was to systematically evaluate the overall-effects of acute exercise on the different SC-subgroups and investigate possible subject- and intervention-dependent factors affecting the extent of SC-mobilization in healthy humans. Trials assessing SC numbers before and at least one timepoint after acute exercise, were identified in a systematic computerized search. Compared to baseline, numbers were significantly increased for early and non-specified SCs (enSCs) until up to 0.5 h after exercise (0–5 min: +0.64 [Standardized difference in means], p < 0.001; 6–20 min: +0.42, p < 0.001; 0.5 h: +0.29, p = 0.049), for ESCs until 12–48 h after exercise (0–5 min: +0.66, p < 0.001; 6–20 min: +0.43 p < 0.001; 0.5 h: +0.43, p = 0.002; 1 h: +0.58, p = 0.001; 2 h: +0.50, p = 0.002; 3–8 h: +0.70, p < 0.001; 12–48 h: +0.38, p = 0.003) and for HSCs at 0–5 min (+ 0.47, p < 0.001) and at 3 h after exercise (+ 0.68, p < 0.001). Sex, intensity and duration of the intervention had generally no influence. The extent and kinetics of the exercise-induced mobilization of SCs differ between SC-subpopulations. However, also definitions of SC-subpopulations are non-uniform. Therefore, finding a consensus with a clear definition of cell surface markers defining ESCs, HSCs and MSCs is a first prerequisite for understanding this important topic. Graphical Abstract

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Circulating angiogenic cell response to sprint interval and continuous exercise

Cited by 17 publications

References 41 publications

Acute Exercise-Induced Oxidative Stress Does Not Affect Immediate or Delayed Precursor Cell Mobilization in Healthy Young Males

Acute Exercise-Induced Oxidative Stress Does Not Affect Immediate or Delayed Precursor Cell Mobilization in Healthy Young Males

Comparison of the lymphocyte response to interval exercise versus continuous exercise in recreationally trained men

Changes in Circulating Stem and Progenitor Cell Numbers Following Acute Exercise in Healthy Human Subjects: a Systematic Review and Meta-analysis

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