Circulating Antigens and Antibodies in Human and Mouse Dermatophytosis: Use of Monoclonal Antibody Reactive to Phosphorylcholine-like Epitopes

Calderón, Raquel A.; Hay, Roderick J.; Shennan, Graham I.

doi:10.1099/00221287-133-9-2699

Cited by 3 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antibodies against dermatophyte products were detected under suitable conditions in the blood and tissue of individuals with dermatophyte infections 95–99 . However, a Th‐2 response appears to provide no protection against invading dermatophytes; 16,100 immediate hypersensitivity to dermatophyte antigens more likely corresponds to persistent disease 92 .…”

Section: Specific Immune Responsementioning

confidence: 99%

Current knowledge of host response in human tinea

Brasch

2009

Mycoses

View full text Add to dashboard Cite

Skin infection caused by dermatophytes is called tinea. In this short review, the known mechanisms and factors involved in human tinea and important for the host response are briefly delineated. To establish tinea, fungal propagules must attach to the skin, germinate and overcome the epidermal barrier. Keratinases and other enzymes are released in this process and host keratinocytes are activated. This is followed by an inflammatory response mediated by a plentitude of cytokines and receptors, comprising innate as well as acquired immunity, including neutrophilic granulocytes, macrophages, antibodies and T cells. Cellular defence mechanisms appear to be decisive for clearing of infection. Nails and hair follicles are the particular sites often invaded by dermatophytes that show distinctive patterns of infection. Nails are largely excluded from defence mechanisms and steroid hormones of the pilosebaceous units may have a particular effect on follicular infection. Fungal invasion of the dermis can cause granulomatous reactions. Immune reactions to dermatophytes may lead to sterile eruptions distant from the infected skin areas.

show abstract

Section: Specific Immune Responsementioning

confidence: 99%

Current knowledge of host response in human tinea

Brasch

2009

Mycoses

View full text Add to dashboard Cite

show abstract

“…Suppression of lymphocyte blastogenic responses has been related to potentially immunosuppressive serum factors in acute Trichophyton mentagrophytes infections produced experimentally in animals (37,102). Studies with human patients also suggest that serum factors may be involved in suppression of cell-mediated immunity to fungal antigens in chronic dermatophytosis (39,229,278). A mannan component of Trichophyton rubrum has been shown to be immunosuppressive of in vitro lymphocyte function (27), perhaps because it preferentially binds to monocytes (95).…”

Section: Dermatophytosismentioning

confidence: 99%

Cutaneous defenses against dermatophytes and yeasts

1995

View full text Add to dashboard Cite

Predispositions to the superficial mycoses include warmth and moisture, natural or iatrogenic immunosuppression, and perhaps some degree of inherited susceptibility. Some of these infections elicit a greater inflammatory response than others, and the noninflammatory ones are generally more chronic. The immune system is involved in the defense against these infections, and cell-mediated immunity appears to be particularly important. The mechanisms involved in generating immunologic reactions in the skin are complex, with epidermal Langerhans cells, other dendritic cells, lymphocytes, microvascular endothelial cells, and the keratinocytes themselves all participating in one way or another. A variety of defects in the immunologic response to the superficial mycoses have been described. In some cases the defect may be preexistent, whereas in others the infection itself may interfere with protective cell-mediated immune responses against the organisms. A number of different mechanisms may underlie these immunologic defects and lead to the development of chronic superficial fungal infection in individual patients. Although the immunologic defects appear to be involved in the chronicity of certain types of cutaneous fungal infections, treatment of these defects remains experimental at the present time.

show abstract

Immunology of Dermatophytosis.

Hay

1994

Jpn J Med Mycol

View full text Add to dashboard Cite

Resistance to dermatophyte fungi depends on both non-specific and specific immunological mechanisms. Amongst the former epidermal proliferation, unsaturated transferrin and fatty acids in sebum play major roles. In addition activated phagocytic cells destroy modulation due to the presence of factor (s) derived from dermatophytes may play a role in determining the course of infection in some patients.

show abstract

Circulating Antigens and Antibodies in Human and Mouse Dermatophytosis: Use of Monoclonal Antibody Reactive to Phosphorylcholine-like Epitopes

Cited by 3 publications

References 12 publications

Current knowledge of host response in human tinea

Current knowledge of host response in human tinea

Cutaneous defenses against dermatophytes and yeasts

Immunology of Dermatophytosis.

Contact Info

Product

Resources

About