Circulating autoantibodies as serological markers in the differential diagnosis of pulmonary renal syndrome

Saxena, Ramesh; Bygren, Per; Arvastson, Bertil; Wieslander, Jörgen

doi:10.1111/j.1365-2796.1995.tb00912.x

Cited by 57 publications

(60 citation statements)

References 23 publications

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“…The duration of respiratory symptoms before hospital admission is a predictive factor. Previous studies have shown that DAH often occurs as a slow, evolving process in vasculitis [10,33]. In contrast, DAH frequently has a sudden onset in SLE [7].…”

Section: Discussionmentioning

confidence: 99%

Alveolar Haemorrhage in the Immunocompetent Host: A Scale for Early Diagnosis of an Immune Cause

et al. 2010

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Background: Diffuse alveolar haemorrhage (DAH) is a life-threatening condition due to immune and non-immune causes. Early identification of an underlying immune disorder is essential in order to initiate appropriate treatment. Objective: The purpose of this study was to identify early predictive factors of an immune cause of DAH. Methods: We conducted a retrospective study of 76 immunocompetent patients with DAH to identify early predictive factors of immune-related DAH using clinical, radiological and routine biological data available in the first 24 h after hospital admission. Results: Multivariate analysis identified 4 parameters which were independently associated with immune-related DAH: (1) onset of first respiratory symptoms ≧11 days, (2) fatigue and/or weight loss during the month prior to presentation, (3) arthralgias or arthritis and (4) proteinuria ≧1 g/l. A simplified scale was constructed using these variables, with an area under the receiver operating characteristic curve of 0.913, for the diagnosis of immune-related DAH. Conclusions: A simple diagnostic scale can be used to identify an immune-related cause of DAH in immunocompetent patients and may help guide treatment decisions such as initiation of steroid therapy on the day of admission.

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Section: Discussionmentioning

confidence: 99%

Alveolar Haemorrhage in the Immunocompetent Host: A Scale for Early Diagnosis of an Immune Cause

et al. 2010

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“…The rapid availability of these antibodies has improved the time to establish an early diagnosis, which is prognostically relevant [Saxena 1995]. …”

Section: Diseasementioning

confidence: 99%

Differential Diagnosis of the Pulmonary-Renal Syndrome

Kimmel¹,

Braun²,

Alscher³

2011

An Update on Glomerulopathies - Clinical and Treatment Aspects

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“…The differential diagnosis of pulmonary-renal syndrome is even more limited with 65-80% of cases resulting from either WG, MPA, or Goodpasture syndrome (GS). [13][14][15] Chest imagingfindings of cavities or nodules As the SVV mimic vastly more common entities such as pneumonia or ARDS, the key to diagnosis is to note features that are inconsistent with the natural history …”

Section: -12mentioning

confidence: 99%