Circulating biomarkers of inflammaging and Alzheimer’s disease to track age-related trajectories of dementia: Can we develop a clinically relevant composite combination?

Abbatecola, Angela Marie; Giuliani, Angelica; Biscetti, Leonardo; Scisciola, Lucia; Battista, Petronilla; Barbieri, Michelangela; Sabbatinelli, Jacopo; Olivieri, Fabiola

doi:10.1016/j.arr.2024.102257

Cited by 3 publications

(3 citation statements)

References 110 publications

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“…Some of the inflammatory blood biomarkers associated with neurodegeneration include cytokines (such as IL-6, IL-8, and TNF-α), chemokines (such as MCP-1), growth factors (such as VEGF), and immune-related proteins (such as ICAM-1 and VCAM-1). These biomarkers have been found to be altered in the serum of patients with AD and MCI [ 50 , 51 , 52 ]. Elevated levels of C-reactive protein (CRP) have been associated with an increased risk of AD and PD [ 53 , 54 ].…”

Section: Is Neurodegeneration An Extraintestinal Manifestation Of Ibds?mentioning

confidence: 99%

“…Neuroinflammation is a common feature of these diseases, and inflammatory biomarkers may aid in their diagnosis. Inflammatory markers in the CSF have been identified in patients with PD, LBD, and AD [ 50 , 53 , 54 ]. These biomarkers can potentially contribute to the development of diagnostic panels for these neurodegenerative diseases.…”

Section: Inflammatory Biomarkersmentioning

confidence: 99%

“…In AD, SAA has been shown to contribute to oxidative stress, mitochondrial dysfunction, impaired synaptic transmission, disruption of membrane integrity, and impaired axonal transport [ 204 ]. Additionally, SAA has been found to interact with other pathological proteins, such as beta-amyloid and alpha-synuclein, forming toxic hetero-aggregates [ 15 , 50 , 205 ].…”

Section: Inflammatory Biomarkersmentioning

confidence: 99%

See 2 more Smart Citations

From Gut to Brain: Uncovering Potential Serum Biomarkers Connecting Inflammatory Bowel Diseases to Neurodegenerative Diseases

Sarb,

Iacobescu

et al. 2024

IJMS

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Inflammatory bowel diseases (IBDs) are characterized by chronic gastrointestinal inflammation due to abnormal immune responses to gut microflora. The gut–brain axis is disrupted in IBDs, leading to neurobiological imbalances and affective symptoms. Systemic inflammation in IBDs affects the brain’s inflammatory response system, hormonal axis, and blood–brain barrier integrity, influencing the gut microbiota. This review aims to explore the association between dysregulations in the gut–brain axis, serum biomarkers, and the development of cognitive disorders. Studies suggest a potential association between IBDs and the development of neurodegeneration. The mechanisms include systemic inflammation, nutritional deficiency, GBA dysfunction, and the effect of genetics and comorbidities. The objective is to identify potential correlations and propose future research directions to understand the impact of altered microbiomes and intestinal barrier functions on neurodegeneration. Serum levels of vitamins, inflammatory and neuronal damage biomarkers, and neuronal growth factors have been investigated for their potential to predict the development of neurodegenerative diseases, but current results are inconclusive and require more studies.

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Section: Is Neurodegeneration An Extraintestinal Manifestation Of Ibds?mentioning

confidence: 99%

Section: Inflammatory Biomarkersmentioning

confidence: 99%

Section: Inflammatory Biomarkersmentioning

confidence: 99%

See 1 more Smart Citation

From Gut to Brain: Uncovering Potential Serum Biomarkers Connecting Inflammatory Bowel Diseases to Neurodegenerative Diseases

Sarb,

Iacobescu

et al. 2024

IJMS

View full text Add to dashboard Cite

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Decoding paradoxical links of cytokine markers in cognition: Cross talk between physiology, inflammaging, and Alzheimer’s disease- related cognitive decline

Khan,

Naseem,

Kaushik

et al. 2024

Ageing Research Reviews

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Investigating interleukin-8 in Alzheimer's disease: A comprehensive review

Righi,

Manco,

Pardini

et al. 2024

Journal of Alzheimer’s Disease

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Several studies indicate that the development of Alzheimer's disease (AD) has strong interactions with immune mechanisms within the brain, indicating a close association between inflammation in the central nervous system and the progression of neurodegeneration. Despite considerable progress in understanding the inflammatory aspects of AD, several of them remain unresolved. Pro-inflammatory cytokines and microglia are pivotal components in the inflammatory cascade. Among these, the role of interleukin-8 (IL-8) in neurodegeneration seems complex and multifaceted, involving inflammation, neurotoxicity, blood-brain barrier disruption, and oxidative stress, and is still poorly characterized. We conducted a review to describe the evidence of IL-8 involvement in AD. IL-8 is a cytokine known for its proinflammatory properties and typically produced by macrophages, predominantly functions as a chemotactic signal for attracting neutrophils to inflamed sites in the bloodstream. Interestingly, IL-8 is also present in the brain, where it is primarily released by microglia in response to inflammatory signals. This review aims to provide a comprehensive overview of the structure, function, and regulatory mechanisms of IL-8 relevant to AD pathology.

show abstract

Circulating biomarkers of inflammaging and Alzheimer’s disease to track age-related trajectories of dementia: Can we develop a clinically relevant composite combination?

Cited by 3 publications

References 110 publications

From Gut to Brain: Uncovering Potential Serum Biomarkers Connecting Inflammatory Bowel Diseases to Neurodegenerative Diseases

From Gut to Brain: Uncovering Potential Serum Biomarkers Connecting Inflammatory Bowel Diseases to Neurodegenerative Diseases

Decoding paradoxical links of cytokine markers in cognition: Cross talk between physiology, inflammaging, and Alzheimer’s disease- related cognitive decline

Investigating interleukin-8 in Alzheimer's disease: A comprehensive review

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