Circulating blood biomarkers in essential hypertension: a literature review

Shere, Amar; Eletta, Olanrewaju; Goyal, Hemant

doi:10.21037/jlpm.2017.12.06

Cited by 29 publications

(29 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are more than one billion individuals suffering from hypertension, making this condition a worldwide public health concern. A chronic disease of high prevalence, hypertension is the main avoidable risk factor for myocardial infarction, heart failure, and peripheral vascular disease, being responsible for a 54% stroke-related mortality rate and a 47% mortality rate associated with coronary heart disease at a global level [2,40,41]. Although different types of medication are available to successfully manage hypertension and prevent CVD, they have negative side-effects that frequently restrict their usage.…”

Section: Discussionmentioning

confidence: 99%

“…When the blood is pumped continuously through the blood vessels with an inordinate amount of force, the blood pressure is classified as high (hypertension) [1]. Hypertension is a primary risk factor for a range of conditions, including stroke, coronary artery disease (CAD), myocardial infarction, kidney disease, heart failure, and peripheral vascular disease, which is why it is a major issue for public health [2]. Indeed, in both developed and developing nations, hypertension is associated with a high mortality and morbidity rate because it is widely prevalent and can heighten the likelihood of cardiovascular disease (CVD) and atherosclerosis [3,4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sinapic Acid Attenuates Cardiovascular Disorders in Rats by Modulating Reactive Oxygen Species and Angiotensin Receptor Expression

Aldubayan

Ahmed

Emara

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The main avoidable risk factor for cardiovascular conditions is high blood pressure (hypertension). At global level, hypertension is believed to be responsible for a 54% stroke-related mortality rate and a 47% mortality rate associated with coronary heart disease. It is postulated that sinapic acid (SA) could help in hypertension management because it displays robust antioxidant, antihyperglycemic, and peroxynitrite scavenging effects. To explore this hypothesis, this work examined the effect of SA on oxidative stress and cardiovascular disease in rats with hypertension by comparison against captopril. For this purpose, 50 male rats were used and equally allocated to five groups, namely, normal control, positive control (L-NAME), L-NAME with concomitant captopril administration, L-NAME with concomitant SA administration, and L-NAME with concomitant administration of both SA and captopril. Results showed that, by contrast to control, L-NAME exhibited marked elevation in serum CK-MB, total cholesterol, triglycerides, VLDL-C, LDL-C, Ang II, AT2R, ET-1, and angiopoietin-2; on the other hand, L-NAME exhibited marked reduction in serum HDL-C, superoxide dismutase (SOD) activity, nitric oxide synthase 3 (NOS3), and glutathione (GSH). Furthermore, joint administration of SA and captopril ameliorated hypertension, enhanced cardiovascular function, hindered hyperlipidemia, and decreased oxidative stress and myocardial hypertrophy displayed by rats with hypertension. Based on such findings, better chemopreventive or therapeutic approaches can be devised to manage hypertension and cardiovascular conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sinapic Acid Attenuates Cardiovascular Disorders in Rats by Modulating Reactive Oxygen Species and Angiotensin Receptor Expression

Aldubayan

Ahmed

Emara

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…N-terminal brain natriuretic pro-peptide (NT-proBNP) is a validated marker for heart failure and CV events [12][13][14]. These markers are shown to be associated with development and progression of hypertension and the resulting end-organ damage [15]. Hypertension is one of the most prevalent CV risk factors [16,17].…”

Section: Introductionmentioning

confidence: 99%

Body composition indices and cardiovascular risk in type 2 diabetes. CV biomarkers are not related to body composition

et al. 2020

View full text Add to dashboard Cite

AbstractBackgroundThis study aims to explore the correlations of body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR) and body composition with levels of asymmetric dimethylarginine (ADMA), endothelin 1(ET-1), N-terminal brain natriuretic pro-peptide (NT-proBNP) and calculated cardiovascular risks.Methods102 women and 67 men with type 2 diabetes participated. Serum levels of NT-proBNP were measured by electro-hemi-luminescence while ELISA were used for ADMA and ET-1. Cardiovascular risks were calculated using the Framingham Risk Score (FRS), the UKPDS 2.0 and the ADVANCE risk engines. Statistical analysis was performed on an IBM SPSS 19.0.ResultsThe BMI outperformed all other indices of obesity (WC, WHtR, WHR), as well as body composition parameters (body fat%, fat mass, fat free mass and total body water) in relation to the estimated risks for coronary heart disease and stroke, based on different calculators. The correlations of the obesity indices with the serum cardiovascular biomarkers were not significant except for BMI and fat mass versus ET-1, and for fat free mass and total body water versus ADMA.ConclusionsThe WC, WHR, WHtR, BF%, FM and FFM apparently do not add significant information related to the levels of cardiovascular biomarkers or the calculated CV-risks.

show abstract

“…In this form, the plasma membrane-bound sACE2 may provide vasoprotective and anti-proliferative actions to counteract RAS [50]. Increased sACE2 activity correlates with heart failure and hypertension [51]. sACE2 seems to have a protective role on the regulation of RAS.…”

Section: Soluble Angiotensin-converting Enzyme 2 (Sace2)mentioning

confidence: 99%

Vaccines against components of the renin–angiotensin system

et al. 2020

View full text Add to dashboard Cite

Even though effective drugs for treating hypertension are available, a great percentage of patients have inadequate control of their blood pressure. Unwanted side effects and inappropriate oral drug adherence are important factors that contribute to the global problem of uncontrolled hypertension. Vaccination could provide a revolutionary therapy with long-lasting effects, increasing patient compliance and therefore better control of high blood pressure. Nowadays, current immunization approaches against hypertension target renin, angiotensin I, angiotensin II, and angiotensin II type 1 receptor, key elements of the renin-angiotensin system. This article reviews the different vaccination attempts with proteins and peptides against the different molecules of the renin-angiotensin system in the last two decades, safety issues, and other novel prospects biomarkers in hypertension, and summarizes the potential of this immunomodulatory approach in clinical practice.

show abstract

Circulating blood biomarkers in essential hypertension: a literature review

Cited by 29 publications

References 0 publications

Sinapic Acid Attenuates Cardiovascular Disorders in Rats by Modulating Reactive Oxygen Species and Angiotensin Receptor Expression

Sinapic Acid Attenuates Cardiovascular Disorders in Rats by Modulating Reactive Oxygen Species and Angiotensin Receptor Expression

Body composition indices and cardiovascular risk in type 2 diabetes. CV biomarkers are not related to body composition

Vaccines against components of the renin–angiotensin system

Contact Info

Product

Resources

About