Circulating carboxy-terminal propeptide of type I procollagen is increased in rheumatic heart disease

Banerjee, Tanima; Mukherjee, Saikat; Biswas, Monodeep; Dutta, Sirshak; Chatterjee, Shelly; Ghosh, Sudip; Pattari, Sanjib; Nanda, Navin C.; Bandyopadhyay, Arun

doi:10.1016/j.ijcard.2012.01.026

Cited by 6 publications

(9 citation statements)

References 12 publications

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“…Earlier it was reported that PICP may determine clinical severity in mitral stenosis since it inversely correlated with MVA and positively correlated with PASP in mitral stenosis with mild or no mitral regurgitation [14]. But the association of other markers of ECM remodelling like PIIINP and MMP-1/TIMP-1 ratio with the above parameters were not dealt with previously.…”

Section: Discussionmentioning

confidence: 98%

“…All control subjects included in the study were normotensive, had normal cardiac function and lipid profile and also had normal fasting blood glucose levels. Most of the subjects who were recruited earlier have again been included in this study for comparing the different markers of collagen metabolism in mitral stenosis and regurgitation respectively which was not shown previously [14] .…”

Section: Methodsmentioning

confidence: 99%

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Clinical Significance of Markers of Collagen Metabolism in Rheumatic Mitral Valve Disease

et al. 2014

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BackgroundRheumatic Heart Disease (RHD), a chronic acquired heart disorder results from Acute Rheumatic Fever. It is a major public health concern in developing countries. In RHD, mostly the valves get affected. The present study investigated whether extracellular matrix remodelling in rheumatic valve leads to altered levels of collagen metabolism markers and if such markers can be clinically used to diagnose or monitor disease progression.MethodologyThis is a case control study comprising 118 subjects. It included 77 cases and 41 healthy controls. Cases were classified into two groups- Mitral Stenosis (MS) and Mitral Regurgitation (MR). Carboxy-terminal propeptide of type I procollagen (PICP), amino-terminal propeptide of type III procollagen (PIIINP), total Matrix Metalloproteinase-1(MMP-1) and Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) were assessed. Histopathology studies were performed on excised mitral valve leaflets. A p value <0.05 was considered statistically significant.ResultsPlasma PICP and PIIINP concentrations increased significantly (p<0.01) in MS and MR subjects compared to controls but decreased gradually over a one year period post mitral valve replacement (p<0.05). In MS, PICP level and MMP-1/TIMP-1 ratio strongly correlated with mitral valve area (r = −0.40; r = 0.49 respectively) and pulmonary artery systolic pressure (r = 0.49; r = −0.49 respectively); while in MR they correlated with left ventricular internal diastolic (r = 0.68; r = −0.48 respectively) and systolic diameters (r = 0.65; r = −0.55 respectively). Receiver operating characteristic curve analysis established PICP as a better marker (AUC = 0.95; 95% CI = 0.91−0.99; p<0.0001). A cut-off >459 ng/mL for PICP provided 91% sensitivity, 90% specificity and a likelihood ratio of 9 in diagnosing RHD. Histopathology analysis revealed inflammation, scarring, neovascularisation and extensive leaflet fibrosis in diseased mitral valve.ConclusionsLevels of collagen metabolism markers correlated with echocardiographic parameters for RHD diagnosis.

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Section: Discussionmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Clinical Significance of Markers of Collagen Metabolism in Rheumatic Mitral Valve Disease

et al. 2014

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“…Carboxy-terminal propeptide of type I procollagen is an indicator for collagen synthesis, which is secreted in the blood during any collagen-related remodelling. PICP level has been reported to be elevated in various disease conditions including RHD 8 19 . In this study, quantification of serum PICP in three disease groups showed gradual increase from pharyngitis to RF, with highest concentration in RHD patients.…”

Section: Discussionmentioning

confidence: 99%

“…MBL2 is an important part of complement cascade of immune system and plays an important role in pathogen recognition and complement system activation. Polymorphism in this gene may lead to increased susceptibility to various diseases including RF and RHD 8 27 , where alteration in the immune response is linked to disease pathogenesis. We have earlier reported association of HLA class II genes with the genetic susceptibility in RHD 28 .…”

Section: Discussionmentioning

confidence: 99%

“…Procollagen type 1 C-peptide (PICP) is secreted into the circulation during collagen synthesis, and an elevated level is attributed to collagen-related disease. The carboxy-terminal PICP in serum of RHD patient group has been reported to be associated with the severity of heart valve damage 8 . Therefore, such interacting factors/biomolecules could be used as potential disease markers.…”

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Association of rheumatic fever & rheumatic heart disease with plausible early & late-stage disease markers

Sarkar

Rastogi

Chaudhary

et al. 2017

Indian Journal of Medical Research

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Background & objectives:Rheumatic fever (RF) and rheumatic heart disease (RHD) are the autoimmune sequelae caused by Group A Streptococcus. RHD still remains a major concern in the developing countries due to its poor diagnosis, lack of vaccines and social awareness among population. This study was aimed to identify the plausible early- and late-stage disease markers associated with RF/RHD.Methods:A total of 84 patients with confirmed pharyngitis (n=18), RF (n=23) and RHD (n=43) were included in the comparative analysis of different factors involved in host-pathogen interaction during RF/RHD pathogenesis.Results:This study revealed high titre of serum antistreptolysin O (ASO) antibody in pharyngitis compared to RF and RHD patients, whereas procollagen type 1 C-peptide (PICP) level was elevated in RHD which showed an inverse correlation with serum ASO titre. The significant elevation of serum anti-peptide associated with RF (PARF) antibody in RF patients was correlated as a probable stage-specific determinant. In addition, pro-inflammatory cytokine profile revealed high levels of interleukin-12 (IL-12)/IL-23p40, IL-17A in RF, whereas IL-6 concentration was higher in RHD compared to healthy controls.Interpretation & conclusions:The overall assessment of the factors/disease markers involved in host-pathogen interaction in RF/RHD may be suggestive of plausible disease marker in different groups of patients. Further studies with larger sample need to be done to better understand RF/RHD pathogenesis.

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Mechanistic implications of altered protein expression in rheumatic heart disease

et al. 2020

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Circulating carboxy-terminal propeptide of type I procollagen is increased in rheumatic heart disease

Cited by 6 publications

References 12 publications

Clinical Significance of Markers of Collagen Metabolism in Rheumatic Mitral Valve Disease

Clinical Significance of Markers of Collagen Metabolism in Rheumatic Mitral Valve Disease

Association of rheumatic fever & rheumatic heart disease with plausible early & late-stage disease markers

Mechanistic implications of altered protein expression in rheumatic heart disease

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