Circulating CD34-positive cells, glomerular filtration rate and triglycerides in relation to hypertension

Shimizu, Yūji; Sato, Shimpei; Koyamatsu, Jun; Yamanashi, Hirotomo; Nagayoshi, Mako; Kadota, Koichiro; Maeda, Takahiro

doi:10.1016/j.atherosclerosis.2015.08.035

Cited by 23 publications

(30 citation statements)

References 27 publications

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“…7 In the present study, among systolic hypertensive men, circulating CD34-positive cells showed no significant correlation with CIMT, but a significant positive correlation was observed with height. As hypertension might mask the beneficial influence of circulating CD34-psositive cells on endothelial repair, 17 and a Japanese study with a 7.1-year follow up reported that hypertension is the most important metabolic risk factor for stroke, 16 these studies show that the risk of stroke with short stature might be associated with a decreased number of circulating CD34-positive cells.…”

Section: Discussionmentioning

confidence: 95%

“…Additionally, hypertension is the most important metabolic risk factor for stroke in Japanese people, 16 and might mask the beneficial influence of circulating CD34positive cells on endothelial repair. 17 However, hypertension is generally defined both by systolic and diastolic blood pressure. Even through both systolic hypertension and diastolic hypertension are important risk factors for stroke, their risk contributions are not identical.…”

Section: Introductionmentioning

confidence: 99%

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Height is an indicator of vascular maintenance capacity in older men

Shimizu

Sato

Koyamatsu

et al. 2016

Geriatrics Gerontology Int

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Height positively correlates with circulating CD34-positive cells in systolic, but not non-systolic, hypertensive men. As the beneficial effects of circulating CD34-positive cells on endothelial repair might be masked by hypertension where the production of CD34-positive cells is stimulated by hypertension-induced vascular damage, among individuals with systolic hypertension, circulating CD34-positive cells should indicate the limits of endothelial repair. Therefore, height might indicate the capacity for adequate vascular maintenance in older men. Geriatr Gerontol Int 2017; 17: 1729-1736.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Height is an indicator of vascular maintenance capacity in older men

Shimizu

Sato

Koyamatsu

et al. 2016

Geriatrics Gerontology Int

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“…In our previous study, we reported that hypertension masks the beneficial effect of circulating CD34-positive cells as an endothelial repair factor [13]. Therefore, the presence of hypertension might act as a confounding factor in the correlation between platelet count and the number of circulating CD34-positive cells.…”

Section: Introductionmentioning

confidence: 99%

Platelets as an indicator of vascular repair in elderly Japanese men

et al. 2016

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Platelets and circulating CD34-positive cells have been reported to contribute to vascular repair (endothelial repair and developing atherosclerosis). And because hypertension is known to be a strong vascular impairment factors, it should also influence the respective numbers of these factors. To clarify the clinical importance of platelets on vascular repair, we conducted a cross-sectional study of 567 Japanese men aged 60-69 who underwent an annual health check-up between 2013 and 2015. Multiple linear regression analysis of non-hypertensive subjects adjusting for classical cardiovascular risk factors showed that although platelet count did not significantly correlate with carotid intima media thickness (β = −0.05, p = 0.356), it did positively correlate significantly with the natural log of the number of circulating CD34-positive cells (β = 0.26, p < 0.001). In hypertensive subjects, a significant positive correlation was seen between platelets and intima media thickness (β = 0.19, p = 0.008), whereas no significant correlation was seen between platelet count and the natural log of the number of circulating CD34-positive cells (β = 0.11, p = 0.119). Our results indicate that platelet count is an indicator of vascular repair activity (endothelial repair and developing atherosclerosis). Additionally, hypertension might mask the beneficial effects of circulating CD34-positive cells.

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“…An age-adjusted trend test was performed with a regression model for mean values, and a logistic regression model was used for proportion. Since the number of circulating CD34 cells should indicate the presence of underlying endothelial repair activity [6, 14–18] and 0.99 cells/μL was the median value of the circulating CD34-positive cells in our present study, this value was set as the cutoff point, as in our previous study [6]. Logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to determine the influence of HDL on hypertension, and subjects were stratified according to the level of circulating CD34-positive cells (high, low).…”

Section: Methodsmentioning

confidence: 99%

“…Another study reported an inverse correlation between the level of cognitive impairment and the number of circulating CD34-positive cells in patients with vascular-type cognitive impairment [15]. Therefore, subjects with a high level of CD34-positive cells should have elevated endothelial repair activity [6, 16–18]. Since endothelial repair activity should be stimulated by endothelial injury, subjects with a high level of CD34-positive cells should present with endothelial injury similar to participants with stable cardiovascular disease and acute coronary syndrome.…”

Section: Backgroundsmentioning

confidence: 99%

Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels

Shimizu

Sato²,

Koyamatsu

et al. 2017

J Physiol Anthropol

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BackgroundAlthough high-density lipoprotein-cholesterol (HDL) level is inversely correlated with cardiovascular events, HDL is also reported to be positively associated with hypertension, which is a known endothelial impairment factor. Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension.MethodsTo investigate the association between HDL and hypertension in relation to the level of circulating CD34-positive cells, we conducted a cross-sectional study of 477 elderly men aged 60–69 years who participated in general health checkup.ResultsHDL was found to be significantly positively associated with hypertension in subjects with a high level of circulating CD34-positive cells, while no significant association was observed for subjects with low circulating CD34-positive cells. Known cardiovascular risk factors adjusted odds (ORs) and 95% confidence intervals (CIs) of hypertension for increments of one standard deviation (SD) in HDL (13.8 mg/dL) were 1.44 (1.06, 1.96) for subjects with a high level of circulating CD34-positive cells and 0.87 (0.63, 1.19) for subjects with low circulating CD34-positive cells. We also revealed a significant association between HDL level and CD34-positive cell level on hypertension, with fully adjusted p values for the effect of this interaction on hypertension at 0.022.ConclusionsIndependent of known cardiovascular risk factors, HDL was found to be positively associated with hypertension in subjects with a high level of circulating CD34-positive cells but not for subjects with low circulating CD34-positive cells.

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Circulating CD34-positive cells, glomerular filtration rate and triglycerides in relation to hypertension

Cited by 23 publications

References 27 publications

Height is an indicator of vascular maintenance capacity in older men

Height is an indicator of vascular maintenance capacity in older men

Platelets as an indicator of vascular repair in elderly Japanese men

Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels

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