2023
DOI: 10.1002/advs.202206789
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Circulating Cell‐Free DNAs as a Biomarker and Therapeutic Target for Acetaminophen‐Induced Liver Injury

Abstract: Acetaminophen (APAP) overdose is a leading cause of drug‐induced liver injury and acute liver failure, while the detection, prognosis prediction, and therapy for APAP‐induced liver injury (AILI) remain improved. Here, it is determined that the temporal pattern of circulating cell‐free DNA (cfDNA) is strongly associated with damage and inflammation parameters in AILI. CfDNA is comparable to alanine aminotransferase (ALT) in predicting mortality and outperformed ALT when combined with ALT in AILI. The depletion … Show more

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Cited by 12 publications
(3 citation statements)
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“…cfDNA, including neutrophil extracellular traps (Nets), mtDNA, and nuclear DNA, is elevated in patients who overdosed on APAP (Mcgill et al, 2012). Sun et al (2023) observed significantly higher cfDNA levels in DILI patients than in healthy volunteers. In addition, a solid association between cfDNA concentration and AILI occurrence is confirmed in mice, which indicates that cfDNA has the potential to predict AILI.…”
Section: Novel Biomarkersmentioning
confidence: 89%
“…cfDNA, including neutrophil extracellular traps (Nets), mtDNA, and nuclear DNA, is elevated in patients who overdosed on APAP (Mcgill et al, 2012). Sun et al (2023) observed significantly higher cfDNA levels in DILI patients than in healthy volunteers. In addition, a solid association between cfDNA concentration and AILI occurrence is confirmed in mice, which indicates that cfDNA has the potential to predict AILI.…”
Section: Novel Biomarkersmentioning
confidence: 89%
“…Although NAC can alleviate liver injury caused by APAP overdose in the clinic by alleviating oxidative stress, multiple studies strongly support the feasibility of obtaining additional benefits in the treatment of drug‐induced hepatotoxicity through the modulation of hepatocyte‐extrinsic immune mechanisms. [ 36 , 37 ] After demonstrating that Mas could be an attractive target for promoting the resolution of inflammation, it may be interesting to integrate NAC with Mas as a combination strategy for antioxidant and anti‐inflammatory activities in the future. A sophisticated combination therapy targeting both inflammation and oxidative damage may prove to be a promising avenue for addressing AILI as well as other liver injuries and diseases.…”
Section: Discussionmentioning
confidence: 99%
“…As a key substance that causes inflammatory damage in TMJ OA, removal of cfDNA may be a new important strategy for inhibiting the inflammatory response and treating TMJ OA. Cationic nanomaterials have shown favorable therapeutic effects on many inflammatory diseases, including sepsis, acute liver failure, , lupus erythematosus, and inflammatory bowel disease, by effectively removing cfDNA. The PAMAM dendrimer is characterized by a well-structured, highly branched, and reactive nature and has shown excellent binding and clearance capabilities for cfDNA.…”
Section: Discussionmentioning
confidence: 99%