Circulating Cerebral S100B Protein Is Associated with Depressive Symptoms following Myocardial Infarction

Tulner, Dorien; Smith, Otto Robert Frans; Jonge, de Peter; Melle, van Jochum; Slomp, Jannes; Storm, Huib; Quéré, Michel; Boer, Johan A. den; Honig, Adriaan; Korf, Jakob

doi:10.1159/000209860

Cited by 13 publications

(7 citation statements)

References 88 publications

(86 reference statements)

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“…They demonstrated that a single dose of recombinant sTNF-R1 was accompanied by initial inhibition of both BBB permeability and CNS inflammation leading to diminishing of disease symptoms for 5 days. This mechanism might be relevant as in a previous study we demonstrated an increased permeability of the BBB during the first week after MI [42] , which might have long-lasting effects on the upregulated transport of TNF-␣ [38] .…”

Section: Discussionmentioning

confidence: 57%

Antidepressive Effect of Mirtazapine in Post-Myocardial Infarction Depression Is Associated with Soluble TNF-R1 Increase: Data from the MIND-IT

Tulner

Smith²,

Schins³

et al. 2011

Neuropsychobiology

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Background: Depressive disorder after myocardial infarction (MI) is associated with increased cardiac morbidity and mortality. Immune activity such as inflammation might be implicated as an underlying mechanism. The purpose of this study is to investigate whether the response to an antidepressant in post-MI depression is associated with changes of inflammatory markers in serum. Methods: In a double-blind placebo-controlled study with mirtazapine 30 mg/day (50 patients), the antidepressive effect was related to immune activation parameters. The cytokines interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α), the soluble cytokine receptors sIL-6R, sTNF-R1 and sTNF-R2, and the inflammation-sensitive plasma proteins C-reactive protein and neopterin were assessed. Results: Subgroup analyses revealed a highly significant correlation of pronounced sTNF-R1 increase with a decrease in depressive symptoms in antidepressant responders. Conclusion: Significant effects on inflammation accompany the therapeutic efficacy of mirtazapine in contrast to the therapeutic efficacy of placebo and the nontherapeutic efficacy of mirtazapine.

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Section: Discussionmentioning

confidence: 57%

Antidepressive Effect of Mirtazapine in Post-Myocardial Infarction Depression Is Associated with Soluble TNF-R1 Increase: Data from the MIND-IT

Tulner

Smith²,

Schins³

et al. 2011

Neuropsychobiology

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“…When it is present in nanomolar concentrations, S100B acts as a growth and differentiation factor for neurons and astrocytes. When it is present in micromolar concentrations, S100B exerts neurotoxic activity and induces the apoptosis of neurons and astrocytes [28] .The results of this study indicate that serum S100B levels are down regulated in GAD patients compared to healthy controls. Limited researches have reported controversial results of S100B on anxiety, Bergh C D [29] reported patients with elevated S100B suffered more anxiety 3-6 years after cardiac surgery.…”

Section: Discussionmentioning

confidence: 63%

The roles of S100B , IL-1β and IL-2 as neuroinflammation biomarkers in Generalized Anxiety Disorder

Shen¹,

Cui

Ren

et al. 2021

Preprint

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Introduction: S100B is a neurotrophic factor regulates neuronal growth and plasticity via activating astrocytes and microglia through production of neuro-inflammatory molecules like interleukin (IL)-1β involved in many mental disorders, few studies have combined S100B and cytokines to explore their roles as neuro-inflammatory biomarkers in Generalized Anxiety Disorder (GAD). Methods: Serum S100B and cytokines (IL-1β , IL-2, IL-4 and IL-10) of 108 untreated GAD cases and 123 healthy controls were determined by enzyme linked-immuno-sorbent assay (ELISA) and then compared, while Hamilton Anxiety Rating Scale (HAMA) scores were measured to evaluate anxiety severity. Results: The serum S100B and IL-1β, IL-2 levels of GAD cases were lower than HC significantly (P<0.001), the IL-4 level of GAD were higher than HC (P<0.001), while IL-10 had no significant difference between two groups (P=0.215). The ROC area of S100B, IL-1β, IL-2 and IL-4 in diagnosis of GAD was (0.740 ± 0.032) , (0.900 ± 0.021) , (0.920 ± 0.018) and (0.696 ± 0.037) , all of them suggested a good predicting value (P < 0.001) , while the ROC area of IL-10 was (0.544 ± 0.038) (P = 0.251). The sensitivity of S-100B, IL-1β, IL-2 in diagnosis of GAD was 73.1%, 80.6%, 85.2%, while the specificity was 61.0%, 86.2%, 80.5%. The combination ROC area of S100B, IL-1β , IL-2 and IL-4 was (0.985 ± 0.006)(P < 0.001). Serum S100B was positively correlated with IL-2 and IL-4 (P <0.05)., while was negatively with HAMA scores (P <0.001). Conclusion: The serum S-100B, IL-1β, IL-2 levels of GAD were down-regulated while IL-4 was up-regulated, both IL-2 and IL-4 had a good diagnosis value in GAD separately while the combination of S100B and cytokines had a better diagnosis value which means the neuro-inflammation in GAD is a network regulated by many factors.

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“…In a healthy state, the low S100B protein level in brain is maintained. 56 At lower (nM) concentration, it exerts neuroprotective effect by promoting neuronal survival and neuritic outgrowth but at higher concentration (μM) it participates in a cascade of events leading to neuronal degeneration. 57,58 In several neuropathological conditions, a 10-60-fold increase in serum S100B…”

Section: Discussionmentioning

confidence: 99%

Effects of mobile phone electromagnetic radiation on rat hippocampus proteome

Singh

Arya

Nirala

et al. 2022

Environmental Toxicology

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Worldwide, the number of mobile phone users has increased from 5.57 billion in 2011 to 6.8 billion in 2019. However, short-and long-term impact of the electromagnetic radiation emitting from mobile phones on tissue homeostasis with particular to brain proteome composition needs further investigation. In this study, we attempted a global proteome profiling study of rat hippocampus exposed to mobile phone radiation for 20 weeks (for 3 h/day for 5 days/week) to identify deregulated proteins and western blot analysis for validation. As a result, we identified 358 hippocampus proteins, of which 16 showed deregulation (log 2 (exposed/sham) ≥ ±1.0, p-value <.05).Majority of these deregulated proteins grouped into three clusters sharing similar molecular pathways. A set of four proteins (Succinate-semialdehyde dehydrogenase: Aldh5a1, Na + K + transporting ATPase: Atp1b2, plasma membrane calcium transporting ATPase: PMCA and protein S100B) presenting each functional pathway were selected for validation. Western blot analysis of these proteins, in an independent sample set, corroborated the mass spectrometry findings. Aldh5a1 involve in cellular energy metabolism, both Atp1b2 and PMCA responsible for membrane transport and protein S100B have a neuroprotective role. In conclusion, we present a deregulated hippocampus proteome upon mobile phone radiation exposure, which might influence the healthy functioning of the brain.

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Circulating Cerebral S100B Protein Is Associated with Depressive Symptoms following Myocardial Infarction

Cited by 13 publications

References 88 publications

Antidepressive Effect of Mirtazapine in Post-Myocardial Infarction Depression Is Associated with Soluble TNF-R1 Increase: Data from the MIND-IT

Antidepressive Effect of Mirtazapine in Post-Myocardial Infarction Depression Is Associated with Soluble TNF-R1 Increase: Data from the MIND-IT

The roles of S100B , IL-1β and IL-2 as neuroinflammation biomarkers in Generalized Anxiety Disorder

Effects of mobile phone electromagnetic radiation on rat hippocampus proteome

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