Circulating concentrations of cardiac proteins in complicated and uncomplicated <i>Plasmodium falciparum</i> malaria

Ehrhardt, Stephan; Wichmann, Dominic; Hemmer, Christoph Josef; Burchard, Gerd‐Dieter; Brattig, Norbert W.

doi:10.1111/j.1365-3156.2004.01303.x

Cited by 41 publications

(54 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is especially true for myocardial impairment that has recently been demonstrated by our group. Indeed, we have found elevated levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and heart-type fatty acid-binding protein (H-FABP) in complicated malaria cases, indicating myocardial impairment [15]. Children suffering from severe malaria exhibited high levels of cardiac markers.…”

Section: Discussionmentioning

confidence: 98%

Plasmodium falciparum glycosylphosphatidylinositol induces limited apoptosis in liver and spleen mouse tissue

Wichmann

Schwarz²,

Ruppert

et al. 2007

Apoptosis

View full text Add to dashboard Cite

Plasmodium falciparum malaria affects about 500 million people worldwide and is responsible for approximately 2.5 million deaths per year. Glycosylphosphatidylinositol (GPI) is the major anchor for membrane-associated proteins of P. falciparum and GPI plays a major role as a toxin in the pathology of malaria. Therefore, we tested the Electronic Supplementary Material Supplementary material is available in the online version of this article at http://dx.hypothesis that GPI, like LPS, induces apoptosis in vitro and in vital organs of mice. Our data does not provide evidence for direct cardiomyocyte apoptosis induced by GPI in vitro. However, in vivo injection of GPI induced limited apoptosis in mouse liver and spleen tissue. Apoptosis may be due to a direct GPI apoptotic effect or to an indirect effect via the induction of TNFα and nitric oxide production.

show abstract

Section: Discussionmentioning

confidence: 98%

Plasmodium falciparum glycosylphosphatidylinositol induces limited apoptosis in liver and spleen mouse tissue

Wichmann

Schwarz²,

Ruppert

et al. 2007

Apoptosis

View full text Add to dashboard Cite

show abstract

“…This suggests that the mechanism of bnp induction is independent on molecules secreted by leukocytes. The bnp up-regulation after 48 h might be related to the elevated levels of circulating BNP found in the serum of malaria patients [2,3]. A recent study has shown that BNP alone is not able to induce cardiomyocyte apoptosis in vitro but BNP increases the percentage of apoptotic cardiomyocytes due to mild hypoxia [22].…”

Section: Discussionmentioning

confidence: 96%

“…Ehrhardt et al [2,3] recently demonstrated cardiac impairment as one potential lethal complication besides cerebral malaria and anemia during P. falciparum infection. Elevated levels of BNP in vivo indicated a myocardial decompensation and were correlated with lactic acidosis and hypoglycemia in the infected patients [2,3]. The GPI of P. falciparum administered in mice is known to induce lactic acidosis and hypoglycemia [5].…”

Section: Discussionmentioning

confidence: 99%

“…cerebral malaria, coma, and anemia. We have shown that serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and heart-type fatty acidbinding protein (H-FABP) are elevated in patients with complicated malaria, underlining the hypothesis of myocardial impairment in severe infection [2,3]. However, the mechanisms causing myocardial damage remain to be elucidated.…”

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

Glycosylphosphatidylinositol-induced cardiac myocyte death might contribute to the fatal outcome of Plasmodium falciparum malaria

et al. 2008

View full text Add to dashboard Cite

show abstract

“…42 Levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), a sensitive marker of left ventricular dysfunction, have been shown to be elevated in patients presenting with severe malaria. 43 Parasite toxins, host immune mediators, metabolic acidosis, and decreased NO levels have all been implicated as causative for direct myocardial dysfunction. Conduction defects and nonspecific electrocardiogram abnormalities can occur, particularly in patients on quinine therapy.…”

Section: Cardiacmentioning

confidence: 99%

Perioperative considerations of the patient with malaria

Soltanifar

Carvalho

Sultan

2014

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Purpose Malaria is a life-threatening infectious disease caused by the Plasmodium parasite. Increased global travel has resulted in an escalation in the number of imported cases seen in developed countries. Patients with malaria may present for surgery in both endemic and nonendemic countries. This article reviews the perioperative considerations when managing patients with malaria. Source A literature review of anesthesia, perioperative care, and malaria-related articles was performed using the MEDLINE Ò , EMBASE TM , and Web of Science databases to identify relevant articles published in English during . Of the 303 articles matching the search criteria, 265 were excluded based on title and abstract. Eleven of the remaining 38 articles were relevant to anesthesia/perioperative care, and 27 articles were identified as having direct relevance to critical care medicine. Principal findings The majority of imported malaria cases are caused by the falciparum species, which is associated with the greatest degree of morbidity and mortality. Various organ systems may be impacted as a consequence of changes in the structure and function of parasitized erythrocytes. Preoperative assessment should focus on establishing the species of malaria, the severity of disease, assessing the degree of end-organ impairment, and initiating treatment of malaria prior to surgery. Intravenous artesunate is the treatment of choice for severe falciparum malaria. Quinine is a second-line agent but has a narrow therapeutic index and particularly hazardous side effects. Intraoperatively, attention should focus on fluid management, dynamics of cerebral blood flow, and avoidance of hypoglycemia. Postoperative care of severe cases should ideally take place in a critical care unit as there may be ongoing requirements for multi-organ support, including renal replacement therapy, ventilation, and/or inotropic support. The safety of neuraxial anesthesia has not been well studied in the setting of malaria. Conclusions Malaria remains one of the most devastating infectious diseases worldwide. Multiple organ systems can be impacted as a consequence of changes in structure and function of parasitized erythrocytes. Safe perioperative management requires a sound knowledge of all these potential system effects. RésuméObjectif Le paludisme est une maladie infectieuse possiblement fatale due au parasite Plasmodium. La multiplication des voyages à travers le monde a entraîné un accroissement du nombre de cas importés observés dans les pays développés. Les patients atteints de paludisme peuvent nécessiter une chirurgie, aussi bien dans les pays où la maladie est endémique que dans les autres. Cet article passe en revue les considérations périopératoires lors de la prise en charge de patients atteints de paludisme. Source Une revue de la littérature à la recherche d'articles d'anesthésie, de soins périopératoires et en Author contributions Daniel Soltanifar, Brendan Carvalho, and Pervez Sultan all made substantial contributions to the literature review, ...

show abstract

Circulating concentrations of cardiac proteins in complicated and uncomplicated Plasmodium falciparum malaria

Cited by 41 publications

References 20 publications

Plasmodium falciparum glycosylphosphatidylinositol induces limited apoptosis in liver and spleen mouse tissue

Plasmodium falciparum glycosylphosphatidylinositol induces limited apoptosis in liver and spleen mouse tissue

Glycosylphosphatidylinositol-induced cardiac myocyte death might contribute to the fatal outcome of Plasmodium falciparum malaria

Perioperative considerations of the patient with malaria

Contact Info

Product

Resources

About