Circulating E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in men with coronary artery disease assessed by angiography and disturbances of carbohydrate metabolism

Kowalska, Irina; czkowski, Marek Str; Szelachowska, Małgorzata; Kinalska, I; Prokop, Jolanta; rzewska-Gajewska, Hanna Bach; pien, Agnieszka St

doi:10.1053/meta.2002.32802

Cited by 47 publications

(32 citation statements)

References 20 publications

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“…This finding is in accordance with previous studies, reporting on the relation between soluble E-selectin and metabolic control in type 2 DM patients with and without cardiovascular disease [20,22]. Our study extends these findings to include diabetic patients with CHF.…”

Section: Discussionsupporting

confidence: 93%

Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

Kistorp

Chong

Gustafsson

et al. 2008

European J of Heart Fail

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Background: Biomarkers of endothelial dysfunction, such as soluble E-selectin, and von Willebrand factor (vWf) are elevated in patients with chronic heart failure (CHF). The impact of diabetes mellitus (DM) on these biomarkers, and their relation to prognosis remains unknown. Aims: to investigate the impact of DM on plasma levels and the prognostic value of E-selectin and vWf in patients with CHF. Methods and results: Plasma levels of E-selectin and vWf were measured in 195 CHF patients with (n = 48, 24.5%), and without DM, and in 116 age-matched healthy controls. Compared with controls, median plasma E-selectin levels were higher in CHF patients with DM (P = 0.012), but not in CHF patients without DM (P = 0.45); vWf levels were also higher in CHF patients with DM (P b 0.001), but not without DM (P = 0.108). E-selectin was associated with risk of recurrent ischaemic cardiovascular events among CHF patients with DM (HR 2.60; P = 0.009), but not among patients without DM (HR 1.09; P = 0.60) per 1 SD increment in log transformed variable. vWf was not related with outcome in CHF patients with or without DM. Conclusions: Plasma levels of E-selectin and vWf are elevated in CHF patients with DM but not in those without DM. High E-selectin levels may be associated with ischaemic events in patients with DM.

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Section: Discussionsupporting

confidence: 93%

Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

Kistorp

Chong

Gustafsson

et al. 2008

European J of Heart Fail

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“…However, experimental results in human subjects offer less clear evidence for an effect of acute hyperglycemia on ICAM-1. Separate studies (22,23) report that oral glucose challenge increases in vivo-circulating levels of some other cell adhesion molecules, but not ICAM-1. In any case, our ICAM-1 measurements were made in samples from fasting individuals and thus should not reflect acute hyperglycemic effects.…”

mentioning

confidence: 99%

Intercellular Adhesion Molecule-1 Concentration Is Genetically Correlated With Insulin Resistance, Obesity, and HDL Concentration in Mexican Americans

et al. 2004

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The metabolic syndrome and type 2 diabetes are associated with endothelial activation (and thus with inflammatory processes leading to atherosclerosis), but the mechanisms that underlie these associations are not fully understood. Endothelial intercellular adhesion molecule (ICAM)-1 plays an important role in the recruitment of immune cells during the development of atherosclerotic plaque and is a marker of inflammatory disease. We performed bivariate quantitative genetic analyses to estimate genetic and environmental correlations between circulating ICAM-1 concentration and 17 phenotypes associated with the metabolic syndrome. Our study population comprised 428 adults in 20 extended Mexican-American families from the San Antonio Family Heart Study (SAFHS). Circulating ICAM-1 concentration is heritable (h 2 ‫؍‬ 0.56). ICAM-1 concentration showed significant positive genetic correlations (range 0.32-0.52, P < 0.05) with fasting insulin, insulin 2 h after oral glucose challenge, homeostasis model assessment of insulin resistance, BMI, waist circumference, and leptin concentration; negative genetic correlation with HDL3 cholesterol concentration; and negative environmental correlation with adiponectin concentration. Significant genetic correlations were not found between ICAM-1 and fasting or 2-h serum glucose or systolic or diastolic blood pressure. Thus, ICAM-1 expression may share common genetic modulation with traits related to obesity, insulin resistance, and HDL3 cholesterol, but not with hyperglycemia or hypertension per se.

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“…Endothelial dysfunction, a chronic state in which vasoconstrictive stimuli overcome vasodilative stimuli, is associated with insulin resistance from early stages of its development. [37,38,39,40,41] The present study demonstrated that the total and differential leukocyte counts were significantly altered in patients with hyperglycemia because of peripheral white blood cell (WBC) count has been shown to be associated with insulin resistance, type diabetes, coronary artery disease (CAD), stroke, and diabetes micro-and macrovascular complications. Peripheral blood leukocytes are com-posed of polymorphonuclear cells, including monocytes as well as lymphocytes.…”

Section: Discussionmentioning

confidence: 87%

Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM

Al-Ghurabi¹

2015

AJLS

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Abstract:Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leukocyte adhesion molecule-1 (ELAM-1) play an essential role in the early stages of atherogenesis of diabetic patients. Materials and Methods: The study was conducted on 80 male divided into two groups 60 of them had diabetes mellitus and 20 subjects were normal healthy individuals served as a control group. Enzyme linked immune sorbent assay (ELISA) was used for the measurement of serum VCAM-1and ELAM-1and WBC assay executed by automatic hematology analyzer the information of patients were obtained through a questionnaire consisted Patients with other diseases were excluded from the current investigation. Results: This result revealed elevated level of serum VCAM-1and ELAM-1 of Diabetes patients compared with healthy group also differentiation count reveal elevated count of WBC, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil in Diabetes patient as compare with HT group.

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Circulating E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in men with coronary artery disease assessed by angiography and disturbances of carbohydrate metabolism

Cited by 47 publications

References 20 publications

Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

Intercellular Adhesion Molecule-1 Concentration Is Genetically Correlated With Insulin Resistance, Obesity, and HDL Concentration in Mexican Americans

Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM

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