Circulating Endoglin Concentration Is Not Elevated in Chronic Kidney Disease

Abstract

BackgroundSoluble endoglin, a TGF-β receptor, plays a key role in cardiovascular physiology. Whether circulating concentrations of soluble endoglin are elevated in CKD or underlie the high risk of cardiovascular death associated with chronic kidney disease (CKD) is unknown.MethodsIndividuals with and without CKD were recruited at a single center. Estimated glomerular filtration rate (eGFR) was estimated using the modified MDRD study equation and the serum creatinine at the time of recruitment, and patients were assigned to specific CKD stage according to usual guidelines. Serum endoglin concentration was measured by ELISA and univariate and multivariable regression was used to analyze the association between eGFR or CKD stage and the concentration of soluble endoglin.ResultsSerum endoglin was measured in 216 patients including 118 with stage 3 or higher CKD and 9 individuals with end stage renal disease (ESRD). Serum endoglin concentration did not vary significantly with CKD stage (increase of 0.16 ng/mL per 1 stage increase in CKD, P = 0.09) or eGFR (decrease -0.06 ng/mL per 10 mL/min/1.73 m2 increase in GFR, P = 0.12), and was not higher in individuals with ESRD than in individuals with preserved renal function (4.2±1.1 and 4.3±1.2 ng/mL, respectively). Endoglin concentration was also not significantly associated with urinary albumin excretion.ConclusionsRenal function is not associated with the circulating concentration of soluble endoglin. Elevations in soluble endoglin concentration are unlikely to contribute to the progression of CKD or the predisposition of individuals with CKD to develop cardiovascular disease.

Combination of Endoglin and ASCVD Risk Assessment Improves Carotid Subclinical Atherosclerosis Recognition

“…Doghish AS et al found that plasma soluble endoglin increased with the development of diabetic nephropathy with microalbuminuria 27) . However, Charytan DM analyzed soluble endoglin concentrations in a large cohort of individuals, with and without chronic kidney disease, and found no association between soluble endoglin levels and eGFR or urinary albumin excretion 38) .Our study showed soluble endoglin was inversely correlated with eGFR, but the association was not significant after further adjustment. The result indicates the former association may be produced by Quantitative variables are presented as means±standard deviation, quanlitative variables are presented as numbers with percentages.…”

Endoglin: Beyond the Endothelium

“…These data suggest that a substantial part of endoglin in fibrotic liver tissues is cleaved and subsequently released into the circulation system. This might be organ-specific, since, in kidney fibrosis (chronic kidney disease and end stage kidney disease), no changes in sol-eng were observed [123]. Although sol-eng was not elevated in patients, in mouse models for kidney fibrosis, unilateral ureteral obstruction (UUO) significantly elevated the mRNA expression of endoglin within the kidney.…”

Transforming growth factor-beta 1 and endoglin levels in congenital solitary functioning kidney

“…They could not determine significant associations between serum endoglin levels and GFR or urine microalbumin levels. [ 25 ] We also could not identify a significant association between serum endoglin levels and GFR. However, our results revealed higher serum endoglin levels in patients with cSFK.…”