Circulating endothelial cells in patients with acute myeloid leukemia

Wierzbowska, Agnieszka; Robak, Tadeusz; Krawczynska, Anna; Wrzesień‐Kuś, Agata; Pluta, Agnieszka; Cebula, Barbara; Smolewski, Piotr

doi:10.1111/j.1600-0609.2005.00549.x

Cited by 48 publications

(45 citation statements)

References 19 publications

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“…The positive correlations between CECs and EPCs with both total leukocytes count and bone marrow blast count may indicate that the levels of CECs and EPCs are correlated with the tumor mass. These findings are in accordance with those by Wierzbowska et al, who observed that the levels of CECs and EPCs were significantly higher in AML patients than in the control group by a 17-and 18-fold, respectively (13). This is in concordance with previous studies in multiple myeloma (MM), metastatic carcinoma, myelodysplastic syndrome, gastrointestinal stromal disease (GIST), hepatocellular carcinoma, breast cancer, non-Hodgkin's lymphoma (NHL), myelofibrosis and chronic lymphocytic leukemia (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Discussionsupporting

confidence: 93%

“…Additionally, CECs and EPCs could be used as a novel marker for minimal residual disease in chronic myeloid leukemia, as reported by Wu et al (12). Wierzbowska et al suggested that endothelial cells may enhance the survival and proliferation of leukemic blasts and mediate chemotherapy resistance in AML (13). The aim of the present study was to quantify CECs and their progenitors EPCs in patients with AML by flow cytometry at initial diagnosis and after induction chemotherapy, and to correlate these findings with the patients' response to treatment.…”

Section: Circulating Endothelial Cells and Their Progenitors In Acutementioning

confidence: 86%

“…Furthermore, the levels of CECs have been correlated to tumor stage and prognosis (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

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Circulating endothelial cells and their progenitors in acute myeloid leukemia

et al. 2016

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Abstract. Acute myeloid leukemia (AML) is an aggressive hematological malignancy characterized by the accumulation of immature myeloid progenitor cells in the bone marrow. Studies are required to investigate the prognostic and predictive value of surrogate biomarkers. Given the importance of angiogenesis in oncology in terms of pathogenesis as well as being a target for treatment, circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) are promising candidates to serve as such markers. The aim of the present study was to quantify CECs and EPCs in patients with AML at initial diagnosis and following induction chemotherapy, and to correlate these findings with the response to treatment in AML patients. The present study included 40 patients with de novo AML and 20 age-and gender-matched healthy controls. CECs and EPCs were evaluated by flow cytometry at initial diagnosis and after induction chemotherapy (3+7 protocol for AML other than M3 and all-trans-retinoic acid plus anthracycline for M3 disease). CECs and EPCs were significantly higher in AML patients at diagnosis and after induction chemotherapy than in controls. After induction chemotherapy, CECs and EPCs were significantly decreased compared with the levels at initial diagnosis. Patients who achieved complete response (n=28) had lower initial CEC and EPC levels compared with patients who did not respond to treatment. These results suggest that CEC levels are higher in AML patients and may correlate with disease status and treatment response. Further investigations are required to better determine the predictive value and implication of these cells in AML management.

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Section: Discussionsupporting

confidence: 93%

Section: Circulating Endothelial Cells and Their Progenitors In Acutementioning

confidence: 86%

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Circulating endothelial cells and their progenitors in acute myeloid leukemia

et al. 2016

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“…Their number is increased under the influence of angiogenic factors, which was shown in patients with B-CLL 26 and other hematologic malignancies. 27,28 Chemotherapy and antiangiogenic therapy were found to decrease the number and viability of circulating endothelial cells. 26,29 Indirect methods have the advantage of being less invasive; however, when their results are compared with angiogenesis measured by direct methods, the correlation appears poor.…”

Section: Methods To Assess Angiogenesis In Hematologic Malignanciesmentioning

confidence: 99%

Role of angiogenesis in chronic lymphocytic leukemia

Letilović

Vrhovać

Verstovšek

et al. 2006

Cancer

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Angiogenesis is a physiologic process of new blood vessels formation mediated by various cytokines called angiogenic and angiostatic factors. Although its potential pathophysiologic role in solid tumors has been extensively studied for more than 3 decades, enhancement of angiogenesis in chronic lymphocytic leukemia (CLL) and other malignant hematological disorders has been recognized more recently.An increased level of angiogenesis has been documented by various experimental methods both in bone marrow and lymph nodes of patients with CLL. Although the role of angiogenesis in the pathophysiology of this disease remains to be fully elucidated, experimental data suggest that several angiogenic factors play a role in the disease progression. Biologic markers of angiogenesis were also shown to be of prognostic relevance in CLL. The current findings provide the rationale for investigating antiangiogenic agents in CLL. In the current review angiogenesis in CLL is discussed and its potential diagnostic and therapeutic applications. Cancer 2006;107:925-34.

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“…Of note, the presence of CEPCs correlates with angiogenic activity during tumour growth, and anti-angiogenic therapies reduce their numbers in patients with lymphoma [33] , multiple myeloma [34] and acute myeloid leukaemia [35] . In contrast, patients who do not or only partially respond to first-line therapy tend to have increased or stable CEPCs levels.…”

Section: The Clinical Significance Of Epcs In the Circulation And Tummentioning

confidence: 99%

The Role of Endothelial Progenitor Cells in Tumour Vasculogenesis

Ding

Kumar

2008

Pathobiology

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Objective: To review the biological behaviour of endothelial progenitor cells and their role and significance in tumour vasculogenesis. Data Sources: The data in this review were mainly from Medline and PubMed for the relevant articles in English published from March, 1997, to March, 2008. The search terms were ‘endothelial progenitor cells’ (EPCs) and ‘neoplasm’. Articles about the biological behaviour of EPCs and their roles in tumour vasculogenesis were included. Results: EPCs, whose characteristics are similar to those of endothelial cells (ECs) and stem cells, contribute to tumour vasculogenesis during tumour progression. The mobilisation, recruitment, homing and incorporation of EPCs into tumours are multi-step and multi-factor events during tumour vasculogenesis. This complex process requires the participation of many growth factors and cells, such as tumour cells, ECs, stromal cells and EPCs in the tumour microenvironment. However, there is still some debate about EPC distribution, contribution, origin and differentiation in tumour vasculogenesis. Conclusions: The characterisation of tumour-associated EPCs may provide valuable clues for more specific anti-angiogenesis therapy and/or tumour diagnosis. Many challenges remain in understanding definition, differentiation, mobilisation and recruitment of EPCs.

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Circulating endothelial cells in patients with acute myeloid leukemia

Abstract: CEC levels are higher in AML and correlate with disease status and response to treatment. Further investigation should be undertaken to better determine their prognostic value.

Cited by 48 publications

References 19 publications

Circulating endothelial cells and their progenitors in acute myeloid leukemia

Circulating endothelial cells and their progenitors in acute myeloid leukemia

Role of angiogenesis in chronic lymphocytic leukemia

The Role of Endothelial Progenitor Cells in Tumour Vasculogenesis

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