Circulating Endothelial Microparticles Reduce in Concentration Following an Exercise Programme in Women With Polycystic Ovary Syndrome

Kirk, Richard; Madden, Leigh A.; Peart, Daniel J.; Aye, Myint Myint; Atkin, Stephen L.; Vince, Rebecca V.

doi:10.3389/fendo.2019.00200

Cited by 15 publications

(12 citation statements)

References 44 publications

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Section: Introductionmentioning

confidence: 99%

“…Lifestyle interventions (e.g. exercise and dietary energy restriction) may be promising in reducing inflammatory markers including EMPs assessed in platelet-free plasma or their cell-surface proteins measured in serum ( 19 , 20 ). Few available studies on the effects of pharmacological agents for PCOS management on the EMP levels have yielded mixed results.…”

Section: Introductionmentioning

confidence: 99%

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The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome

Javed

Papageorgiou

Madden

et al. 2020

Endocrine Connections

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Context Endothelial microparticles (EMPs) are novel, surrogate biomarkers of endothelial function and have been shown to be elevated in women with polycystic ovary syndrome (PCOS). It remains poorly understood how pharmacological options for managing PCOS affect EMP levels. Objective To characterise and compare the effects of empagliflozin vs metformin on the circulating levels of EMPs in overweight/obese women with PCOS. Methods This was a randomised, comparative, 12-week single-centre trial conducted at the Academic Diabetes, Endocrinology and Metabolism Research Centre, Hull, UK. This analysis includes data from 39 overweight/obese women with PCOS who completed the study and were randomised to empagliflozin (15 mg/day) (n = 19) or metformin (1500 mg/day) (n = 20). Blood samples were collected at baseline and 12 weeks after treatment and analysed for specific surface proteins (ICAM-1, VCAM-1, PECAM-1, E-selectin and endoglin) expressed by circulating EMPs using flow cytometry. Results In the empagliflozin group, ICAM-1 (P = 0.006), E-selectin (P = 0.016) and VCAM-1 (P = 0.001) EMPs increased significantly following 12 weeks of treatment, but no changes were seen in PECAM-1 (P = 0.93) or endoglin (P = 0.13) EMPs. In the metformin group, VCAM-1 EMPs (P < 0.001) increased significantly after 12 weeks of treatment, whereas all other EMPs remained unchanged. When data were expressed as percentage change from baseline in each group, no significant differences were seen between groups for any biomarker (P-values from 0.22 to 0.80). Conclusions Short-term administration of empagliflozin and metformin in overweight/obese women with PCOS appear to increase EMPs expressed by endothelial cells during their activation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome

Javed

Papageorgiou

Madden

et al. 2020

Endocrine Connections

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“…Chronic exercise training was undertaken as explained [ 29 ]. Within a week following the baseline assessment, participants began attending 3 supervised exercise sessions per week for 8 weeks.…”

Section: Methodsmentioning

confidence: 99%

Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training

et al. 2021

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Background Polycystic ovary syndrome (PCOS) is associated with obesity, diabetes, and insulin resistance. The circulating C1Q/TNF-related proteins (CTRP-2, CTRP-9) and growth differentiation factors (GDF-8, GDF-15) contribute to glucose and lipid homeostasis. The effects of intralipids and insulin infusion on CTRP-2, CTRP-9, GDF-8 and GDF-15 in PCOS and control subjects before and after chronic exercise training were examined. Methods Ten PCOS and nine healthy subjects were studied at baseline status and after moderate-intensity chronic exercise training (1 h exercise, 3 times per week, 8 weeks). All participants were infused with 1.5 mL/min of saline or intralipids (20%) for 5 h, and during the last 2 h of saline or intralipids infusion hyperinsulinemic-euglycemic clamp (HIEC) was performed. CTRP-2, CTRP-9, GDF-8 and GDF-15 levels were measured at 0, 3 and 5 h. Results Intralipids dramatically increased CTRP-2 levels in PCOS (P = 0.02) and control (P = 0.004) subjects, which was not affected by insulin infusion or by exercise. Intralipids alone had no effects on CTRP-9, GDF-8, or GDF-15. Insulin increased the levels of GDF-15 in control subjects (P = 0.05) during the saline study and in PCOS subjects (P = 0.04) during the intralipid infusion. Insulin suppressed CTRP9 levels during the intralipid study in both PCOS (P = 0.04) and control (P = 0.01) subjects. Exercise significantly reduced fasting GDF-8 levels in PCOS (P = 0.03) and control (P = 0.04) subjects; however, intralipids infusion after chronic exercise training increased GDF-8 levels in both PCOS (P = 0.003) and control (P = 0.05) subjects and insulin infusion during intralipid infusion reduced the rise of GDF-8 levels. Conclusion This study showed that exogenous lipids modulate CTRP-2, which might have a physiological role in lipid metabolism. Since chronic exercise training reduced fasting GDF-8 levels; GDF-8 might have a role in humoral adaptation to exercise. GDF-15 and CTRP-9 levels are responsive to insulin, and thus they may play a role in insulin responses.

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“…Аналогично ССЗ, характеристики СПКЯ улучшаются при совместном использовании умеренных физических нагрузок и диеты [68]. Важно отметить, что позитивные изменения метаболизма у больных СПКЯ ассоциируются с улучшением эндотелиальной функции, но вместе с тем редукция уровней маркеров дисфункции эндотелия происходит вне зависимости от динамики метаболических параметров, что подтверждает концепцию о самостоятельном влиянии физических упражнений на сосудистое здоровье [69].…”

Section: диабетunclassified

Endothelial dysfunction in context of women’s health disorders from menarche to menopause

Кузнецова

2020

Medicinskij alfavit

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Endothelial function is an essential component of providing homeostasis, which allows controlling the state of the vascular bed and ensuring blood supply to organs both under physiological conditions and under the influence of various damaging factors. Endothelial dysfunction is associated with a wide range of pathological conditions and diseases, in the pathogenesis of which the vascular link is involved. Understanding the unifying role of endothelial dysfunction in the pathology of different fields of medicine allows, firstly, to predict the development of serious socially significant diseases, such as cardiovascular diseases, which remain the main cause of death among women. In particular, over the past decade, several cardiovascular risk factors specific to the female population have been identified, such as hypertensive pregnancy complications and menopausal vasomotor symptoms, which, in turn, are caused by endothelial dysfunction. Secondly, timely treatment of endotheliosis suspends or completely prevents both transient disorders associated with endothelial dysfunction and their serious consequences. In this regard, the drug group of glycosaminoglycans and its representative sulodexide are of interest.

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Circulating Endothelial Microparticles Reduce in Concentration Following an Exercise Programme in Women With Polycystic Ovary Syndrome

Cited by 15 publications

References 44 publications

The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome

The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome

Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training

Endothelial dysfunction in context of women’s health disorders from menarche to menopause

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