Circulating Endothelial Progenitor Cells in Periodontitis

Jönsson, Daniel; Spinell, Thomas; Vrettos, Anastasios; Stoecklin-Wasmer, Christin; Celenti, Romanita; Demmer, Ryan T.; Kebschull, Moritz; Papapanou, Panos N.

doi:10.1902/jop.2014.140153

Cited by 10 publications

(19 citation statements)

References 46 publications

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“…During the last decades, a two-directional, reciprocal relationship between impaired EPC levels and periodontitis has been shown in some studies [14,16,[31][32][33]. Li et al [15] demonstrated that patients who presented moderate to severe periodontitis exhibited an increased risk of high EPC count, compared with those with no or mild periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…The sample size was established considering a number of groups equal to 2, an effect size of 0.5 for CD133 + /KDR + count (that represents the primary periodontal variable), an expected standard deviation of 0.5 [14], a two-sided significance level of 0.05, and a power of 80%. It was determined that approximately 53 patients per group would be needed.…”

Section: Power and Sample Sizementioning

confidence: 99%

“…However, studies that analyzed the association between periodontitis and impaired EPCs reported conflicting results. In some studies, periodontitis was correlated with high levels of EPCs [14,15], whereas some other studies reported a limited association between periodontitis and impaired EPCs, even after adjusting for important confounders [16,17]. However, these studies did not specifically report any association between the extent of periodontitis and CD133 + /KDR + levels and the p-trend of this association.…”

Section: Introductionmentioning

confidence: 97%

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Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Isola

Giudice

Alibrandi

et al. 2019

Genes

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The aim of the present study was to investigate the association and impact of periodontitis and tooth loss on a subtype of endothelial progenitor cell (EPC) levels (CD133+/KDR+). Furthermore, the objective was to determine if the periodontal status influenced CD133+/KDR+ levels. In all, 88 patients with periodontitis and 79 healthy controls (HCs) were enrolled in the study. Enrolled patients were examined and characterized by clinical and blood sample analysis. Spearman’s correlation test was applied in order to assess the interdependence between CD133+/KDR+ levels and all periodontal parameters. In order to estimate a statistically significant trend (p-trend) for ordered CD133++/KDR+ quartiles, the Jonckheere–Terpstra test was applied for all variables. Patients in the periodontitis group presented significantly lower CD133+/KDR+ levels (66.4 (45.5–269.6 cells/µL)) compared to the HC group (76.7 (24.3–313.2 cells/µL), p < 0.001). Lower CD133+/KDR+ levels negatively correlated with C-reactive protein (CRP), with the number of teeth, and with all periodontal parameters (p < 0.001). Moreover, there was a proportional increase in CD133+/KDR+ levels with a progressive increase in number of teeth (p-trend < 0.001), while there was a proportional decrease in CD133+/KDR+ levels with a proportional increase in clinical attachment level (CAL, p-trend = 0.003), probing depth (PD, p-trend = 0.007), and bleeding sites (bleeding on probing (BOP), p-trend < 0.001) as an extent measure of periodontitis. This study demonstrated that patients with periodontitis presented significantly lower CD133+/KDR+ levels compared to HCs. Moreover, all patients presented an increase in the CD133+/KDR+ EPC levels with an extended level of periodontitis and tooth loss.

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Section: Discussionmentioning

confidence: 99%

Section: Power and Sample Sizementioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Isola

Giudice

Alibrandi

et al. 2019

Genes

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“…By comparison to CAL, PD and BOP measure the present disease and inflammation. To further define periodontal disease, we combined historical with current measures of periodontal disease: the presence of CAL ≥ 3mm at ≥ 66% sites and concomitant PD ≥ 5mm was defined as Perio1 (Jonsson, et al, 2014). …”

Section: Methodsmentioning

confidence: 99%

Periodontal disease associates with higher brain amyloid load in normal elderly

Kamer¹,

Pirraglia²,

Tsui³

et al. 2015

Neurobiology of Aging

208

150

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Background The accumulation of amyloid β plaques (Aβ) is a central feature of Alzheimer’s disease (AD). First reported in animal models, it remains uncertain if peripheral inflammatory/infectious conditions in humans can promote Aβ brain accumulation. Periodontal disease, a common chronic infection, has been previously reported to be associated with AD. Methods Thirty-eight cognitively normal, healthy, community residing elderly (mean age 61; 68% female) were examined in an Alzheimer’s Disease research center and a University-based Dental School. Linear regression models (adjusted for age, ApoE and smoking) were used to test the hypothesis that periodontal disease assessed by clinical attachment loss was associated with brain Aβ load using 11C-PIB PET imaging. Results After adjusting for confounders, clinical attachment loss (≥ 3mm), representing a history of periodontal inflammatory/infectious burden, was associated with increased 11C-PIB uptake in Aβ vulnerable brain regions (p=0.002). Conclusion We show for the first time in humans an association between periodontal disease and brain Aβ load. These data are consistent with prior animal studies showing that peripheral inflammation/infections are sufficient to produce brain Aβ accumulations.

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“…Accumulating evidence suggests that periodontitis is associated with cardiovascular disease (CVD) [3][4][5], the leading cause of death [6,7]. One mechanism behind CVD is the development of atherosclerotic plaques and rupture of these plaques in large or medium-size arteries, causing reduced blood flow, ischaemia, thrombo-embolism and end-organ damages.…”

Section: Introductionmentioning

confidence: 99%

Periodontal disease is associated with carotid plaque area: the Malmö Offspring Dental Study (MODS)

et al. 2019

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Background Periodontal disease is associated with cardiovascular disease (CVD) but it is unknown if periodontal disease severity is associated with asymptomatic carotid plaque. The aim of the current population‐based, observational study was to investigate if signs of periodontal disease are associated with the occurrence of carotid plaque and total plaque area (TPA). Methods The Malmö Offspring Study (MOS) is a population‐based study. MOS participants underwent a thorough cardiovascular phenotyping, including carotid ultrasonography. The Malmö Offspring Dental Study (MODS) invited participants of MOS for dental examination, including periodontal charting. Multivariable regression models were used to analyse the presence of carotid plaque and TPA in relation to periodontal parameters. Results In all, 831 MODS participants were recruited, out of which 495 belonged to the children generation with mean age of 53 years, 63% had carotid plaque and 38% had moderate or severe periodontal disease. In models adjusted for CVD risk factors, the OR for having carotid plaque in subjects with vs without periodontal disease was 1.75 (95% CI: 1.11–2.78). In a linear model with TPA as dependent and number of periodontal pockets ≥ 4 mm as independent variable, the adjusted beta‐coefficient was 0.34 mm2 (95% CI 0.16–0.52). Conclusion Individuals within the highest quartile of periodontal pockets are expected to have 9 mm2 larger TPA compared to those without pockets. Our results suggest that intervention studies addressing periodontal disease could be useful for prevention of CVD.

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Circulating Endothelial Progenitor Cells in Periodontitis

Abstract: These findings further support the notion that oral infections have extraoral effects and document that periodontitis is associated with a mobilization of EPCs from the bone marrow, apparently in response to systemic inflammation and endothelial injury.

Cited by 10 publications

References 46 publications

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Periodontal disease associates with higher brain amyloid load in normal elderly

Periodontal disease is associated with carotid plaque area: the Malmö Offspring Dental Study (MODS)

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