Circulating endothelial progenitor cells in women with gestational alterations of glucose tolerance

Penno, Giuseppe; Pucci, Laura; Lucchesi, Daniela; Lencioni, Cristina; Iorio, Mariacarla; Vanacore, Renato; Storti, Eugenia; Resi, Veronica; Cianni, Graziano Di; Prato, Stefano Del

doi:10.1177/1479164111408938

Cited by 14 publications

(12 citation statements)

References 47 publications

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“…In contrary to normal pregnancy, a significantly lower number has been found in pregnant patients with gestational diabetes mellitus and preeclampsia. 26 There are no previous studies looking at circulating EPCs in patients with PPCM.…”

Section: Angiogenic Imbalance In Post-ppcm Women With LV Recoverymentioning

confidence: 99%

Angiogenic Imbalance and Residual Myocardial Injury in Recovered Peripartum Cardiomyopathy Patients

Goland

Weinstein

Zalik

et al. 2016

Circ: Heart Failure

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Background-Recent studies suggest that angiogenic imbalance during pregnancy may lead to acute peripartum cardiomyopathy (PPCM). We propose that angiogenic imbalance and residual cardiac dysfunction may exist even after recovery from PPCM. Methods and Results-Twenty-nine women at least 12 months after presentation with PPCM, who exhibited recovery of left ventricular (LV) ejection fraction (≥50%), were included in the study (mean age 35±6 years, LV ejection fraction 61.0±3.9%). The number of circulating endothelial progenitor cells (EPCs) and plasma levels of proangiogenic vascular endothelial growth factor and of soluble vascular endothelial growth factor receptor Flt1 (sFlt1) Conclusions-Higher concentration of sFlt1 with concomitant decreased circulating endothelial progenitor cell levels along with inappropriate attenuated vascular endothelial growth factor levels may imply an angiogenic imbalance that exists even after recovery and may thus predispose to PPCM. In addition, tissue Doppler imaging and 2D strain were able to identify residual myocardial injury in post-PPCM women with apparent recovery of LV systolic function. Both angiogenic imbalance and residual myocardial injury may play an important role in the recurrence of LV dysfunction during subsequent pregnancies. (Circ Heart Fail. 2016;9:e003349.

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Section: Angiogenic Imbalance In Post-ppcm Women With LV Recoverymentioning

confidence: 99%

Angiogenic Imbalance and Residual Myocardial Injury in Recovered Peripartum Cardiomyopathy Patients

Goland

Weinstein

Zalik

et al. 2016

Circ: Heart Failure

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show abstract

“…Indeed, in previous studies, the recruitment of EPCs was suppressed in both prediabetic patients [13] and women in gestational alterations of glucose tolerance [14], EPCs' declining number correlated with diminished vascular repair capability in both prediabetic [15] and diabetic patients [16]. However, so far, no study has been reported relating to the underlying mechanism of why the inability of circulating EPCs is present in prediabetic individuals.…”

Section: Introductionmentioning

confidence: 95%

Reduced Circulating Endothelial Progenitor Cells and Downregulated GTCPH I Pathway Related to Endothelial Dysfunction in Premenopausal Women with Isolated Impaired Glucose Tolerance

Liu

Xing

et al. 2020

Cardiology Research and Practice

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Background. Individuals at a prediabetic stage have had an augmented cardiovascular disease (CVD) risk and CVD-related mortality compared to normal glucose tolerance (NGT) individuals, which may be attributed to the impaired vascular endothelial repair capacity. In this study, circulating endothelial progenitor cells’ (EPCs) number and activity were evaluated, and the underlying mechanisms in premenopausal women with impaired glucose regulation were explored. Methods. Circulating EPCs’ number and activity and flow-mediated dilation (FMD) were compared in premenopausal women with NGT, isolated impaired fasting glucose (i-IFG), or isolated impaired glucose tolerance (i-IGT). Plasma nitric oxide (NO), EPCs-secreted NO, and intracellular BH4 levels were also measured. The key proteins (Tie2, Akt, eNOS, and GTPCH I) in the guanosine triphosphate cyclohydrolase/tetrahydrobiopterin (GTPCH/BH4) pathway and Tie2/Akt/eNOS signaling pathway were evaluated in these women. Results. It was observed that the i-IGT premenopausal women not i-IFG premenopausal women had a significant reduction in circulating EPCs’ number and activity as well as reduced FMD when compared to NGT subjects. Plasma NO levels or EPCs-secreted NO also decreased only in i-IGT women. The expression of GTCPH I as well as intracellular BH4 levels declined in i-IGT women; however, the alternations of key proteins’ expression in the Tie2/Akt/eNOS signaling pathway were not observed in either i-IGT or i-IFG women. Conclusions. The endothelial repair capacity was impaired in i-IGT premenopausal women but was preserved in i-IFG counterparts. The underlying mechanism may be associated with the downregulated GTCPH I pathway and reduced NO productions.

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“…Recent studies reported that GDM affects the growth and functions of endogenous stem or progenitor cells by inducing oxidative stress, senescence and mitochondrial dysfunctions. For examples, women with GDM have reduced concentration of circulating endothelial progenitor cells in late stages of pregnancy when compared with women without GDM (Acosta et al, 2011; Buemi et al, 2007; Penno et al, 2011). Two recent studies have demonstrated the adverse effect of GDM on proliferation, viability, differentiation and mitochondrial functions in mesenchymal stem cells (MSCs) derived from human umbilical cord (UC) (Kim et al, 2015; Wajid et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Gestational Diabetes Affects the Growth and Functions of Perivascular Stem Cells

Kim

Song

et al. 2017

Molecules and Cells

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Gestational diabetes mellitus (GDM), one of the common metabolic disorders of pregnancy, leads to functional alterations in various cells including stem cells as well as some abnormalities in fetal development. Perivascular stem cells (PVCs) have gained more attention in recent years, for the treatment of various diseases. However, the effect of GDM on PVC function has not been investigated. In our study, we isolated PVCs from umbilical cord of normal pregnant women and GDM patients and compared their phenotypes and function. There is no significant difference in phenotypic expression, response to bFGF exposure and adipogenic differentiation capacity between normal (N)-PVCs and GDM-PVCs. However, when compared with N-PVCs, early passage GDM-PVCs displayed decreased initial rates of cell yield and proliferation as well as a reduced ability to promote wound closure. These results suggest that maternal metabolic dysregulation during gestation can alter the function of endogenous multipotent stem cells, which may impact their therapeutic effectiveness.

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Circulating endothelial progenitor cells in women with gestational alterations of glucose tolerance

Cited by 14 publications

References 47 publications

Angiogenic Imbalance and Residual Myocardial Injury in Recovered Peripartum Cardiomyopathy Patients

Angiogenic Imbalance and Residual Myocardial Injury in Recovered Peripartum Cardiomyopathy Patients

Reduced Circulating Endothelial Progenitor Cells and Downregulated GTCPH I Pathway Related to Endothelial Dysfunction in Premenopausal Women with Isolated Impaired Glucose Tolerance

Gestational Diabetes Affects the Growth and Functions of Perivascular Stem Cells

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