Circulating endothelial progenitor cells predict coronary artery disease severity

Kunz, Geoffrey A.; Liang, Ge; Cuculi, Florim; Gregg, David; Vata, Korkut C.; Shaw, Linda K.; Goldschmidt‐Clermont, Pascal J.; Dong, Chunming; Taylor, Doris A.; Peterson, Eric D.

doi:10.1016/j.ahj.2006.02.001

Cited by 167 publications

(127 citation statements)

References 27 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…Regardless of the actual functional/antigenic correlations, both circulating CD34 + and CD34 + KDR + cells have been found to be reduced in subjects with established atherosclerotic disease [16,33]. Previous studies have also shown that CD34 + KDR + cell count is reduced early on in pre-atherosclerosis and represents an independent predictor of carotid intima-media thickness in the general population [28].…”

Section: Resultsmentioning

confidence: 88%

Glucose tolerance is negatively associated with circulating progenitor cell levels

et al. 2007

View full text Add to dashboard Cite

Aims/hypothesis Circulating progenitor cells participate in cardiovascular homeostasis. Depletion of the pool of endothelial progenitor cells (EPCs) is associated with increased cardiovascular risk. Furthermore, EPCs are reduced in the presence of classical risk factors for atherosclerotic disease, including diabetes mellitus. This study was designed to evaluate progenitor cell levels in volunteers with different degrees of glucose tolerance. Methods Cardiovascular parameters and the levels of circulating CD34 + and CD34 + kinase insert domain receptor (KDR) + cells were determined in 219 middle-aged individuals with no pre-diagnosed alterations in carbohydrate metabolism. Glucose tolerance was determined by fasting and 2 h post-challenge glucose levels, with IFG and IGT considered as pre-diabetic states. Results CD34 + and CD34 + KDR + cells were significantly reduced in individuals who were found to have diabetes mellitus, and were negatively correlated with both fasting and post-challenge glucose in the whole population. While only CD34 + cells, but not CD34 + KDR + cells, were significantly reduced in pre-diabetic individuals, postchallenge glucose was an independent determinant of the levels of both CD34 + and CD34 + KDR + cells. Conclusions/interpretation Glucose tolerance was negatively associated with progenitor cell levels in middle-aged healthy individuals. Depletion of endothelial progenitors with increasing fasting and post-meal glucose may be one cause of the high incidence of cardiovascular damage in individuals with pre-diabetes.

show abstract

Section: Resultsmentioning

confidence: 88%

Glucose tolerance is negatively associated with circulating progenitor cell levels

et al. 2007

View full text Add to dashboard Cite

show abstract

“…In contrast to the vast number of papers elucidating roles of putative bone marrow-derived EPC in cancer (Lyden et al 2001;Mancuso et al 2001Mancuso et al , 2006Mancuso et al , 2009Bertolini et al 2006;Shaked et al 2006;Nolan et al 2007;Gao et al 2008;Seandel et al 2008;Gao and Mittal 2009), cardiovascular disorders (Eizawa et al 2004;Schmidt-Lucke et al 2005;Werner et al 2005;Fadini et al 2006a,b;Kunz et al 2006;Hughes et al 2007), and diabetes (Tepper et al 2002;Eizawa et al 2004;Loomans et al 2004;Fadini et al 2006bFadini et al , 2007, little focus has been placed on fully understanding how these cells may differ in their roles, behavior, or function compared to the rare circulating endothelial cells that may also be involved in many of these same disorders. This overview will attempt to summarize our current understanding of the various cell subsets that circulate in the bloodstream and are all referred to using the same EPC terminology.…”

mentioning

confidence: 99%

Human Endothelial Progenitor Cells

Yoder

2011

Cold Spring Harbor Perspectives in Medicine

351

252

View full text Add to dashboard Cite

“…The number of circulating endothelial progenitor cells (EPC) seem also to be of importance, since diminished EPC counts are associated with higher cardiovascular risk 48 . A recent study investigated whether abnormalities in EPC levels and functions are present in migraine patients 49 .…”

Section: Mechanisms Of Association Putative Mechanisms Commentsmentioning

confidence: 99%

Migraine and Cardiovascular Disease

Lipton¹,

Bigal

2006

JAMA

View full text Add to dashboard Cite

Migraine, especially migraine with aura is an established risk factor for ischemic lesions of the brain. Recent evidence has also linked migraine with and without aura to a broader range of ischemic vascular disorders including angina, myocardial infarction, coronary revascularization, claudication and cardiovascular mortality. The topic is therefore of considerable interest. Accordingly, herein we review the association between migraine and cardiovascular disease. We start by briefly presenting diagnostic criteria for migraine and revising its pathophysiology. We follow by summarizing the evidence on the topic. We then briefly present the results of a recent meta-analysis. We close by highlighting results of a large epidemiological study conducted after the publication of the meta-analysis. Key words: migraine, cardiovascular disease, stroke. Migrânea e doenças cardiovasculares RESUMOA migrânea, especialmente a migrânea com aura, é fator de risco para lesões cerebrais. Evidência recente sugere que migrânea com e sem aura é associada com outras doenças cardiovasculares isquêmicas, incluindo a angina, o infarto do miocárdio, revascularização coronária, claudicação e morte súbita. Iniciamos discutindo o diagnóstico da migrânea e seus mecanismos fisiopatológicos. Após sumarizar a evidência, discutimos resultados de meta-análise recente. Por fim, ressaltamos resultados de um grande estudo populacional sobre o assunto. Palavras-chave: migrânea, doença cardiovascular, acidente vascular cerebral. The association between migraine and ischemic vascular events has been studied for many years 1,2 . Original studies controversially reported an association between migraine with aura (MA) and stroke. The relationship was stronger in young women, and was magnified by the use of hormonal contraception or by tabagism 1 . Controversial topics included whether migraine without aura (MO) was also a risk factor to stroke, if the association also happened in men, and whether migraine was associated with other forms of cardiovascular disease 3 .The field has advanced considerably in recent years, with the publication of evidence that MA is indeed an established risk factor for subclinical ischemic lesions of the brain 4 , as well as for ischemic stroke, particularly among women of younger age 5,6 . The association has also been shown in men 7 . Furthermore, migraine seems also to be linked with other forms of cardiovascular disease (CVD), including myocardial infarct, angina and claudication), as well as with risk factors to CVD 8,9 . The topic has indeed gained considerable traction and robust evidence is now available. Accordingly, herein we review the association between migraine and CVD. We start by briefly presenting diagnostic criteria for migraine and revising its pathophysiology. We follow by summarizing the evidence on the topic. We then briefly present the results of a recent meta-analysis. We close by highlighting results of a large epidemiological study conducted after the publication of the meta-analysis. Migraine...

show abstract

Circulating endothelial progenitor cells predict coronary artery disease severity

Cited by 167 publications

References 27 publications

Glucose tolerance is negatively associated with circulating progenitor cell levels

Glucose tolerance is negatively associated with circulating progenitor cell levels

Human Endothelial Progenitor Cells

Migraine and Cardiovascular Disease

Contact Info

Product

Resources

About