Circulating erythropoietin and interleukin-6 concentrations increase in critically ill children with sepsis and septic shock

Krafte-Jacobs, Brian; Bock, Glenn H.

doi:10.1097/00003246-199609000-00005

Cited by 41 publications

(24 citation statements)

References 21 publications

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“…The circulating erythropoietin concentrations of septic adults in the current study (mean 124 IU/ml) is quite similar to the response seen in a recent study regarding septic children (mean 120 IU/ml) [6]. These circulating erythropoietin concentrations are approximately 6-fold higher than the 95th percentile concentrations reported in healthy adults and children without anemia, yet much lower than the erythropoietin concentrations measured in otherwise healthy adults and children with iron deficiency anemia.…”

supporting

confidence: 83%

Anemia of critical illness and erythropoietin deficiency

Krafte-Jacobs

1997

Intensive Care Medicine

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supporting

confidence: 83%

Anemia of critical illness and erythropoietin deficiency

Krafte-Jacobs

1997

Intensive Care Medicine

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“…The expected inverse relationship between EPO levels and hemoglobin was present in survivors but not in nonsurvivors. Higher levels of EPO in nonsurvivors of septic shock were also noted by Nakamura et al (40) Nonanemic children with sepsis and septic shock have also been found to have increased EPO levels (41).…”

Section: Grade Bsupporting

confidence: 54%

Use of blood products in sepsis: An evidence-based review

Zimmerman

2004

Critical Care Medicine

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In the absence of extenuating circumstances and following resolution of tissue hypoperfusion, red blood cell transfusion should be targeted to maintain hemoglobin at 7.0 g/dL or greater. Erythropoietin is not recommended as a specific treatment for sepsis-associated anemia. Fresh-frozen plasma should be given for documented deficiency of coagulation factors and in the presence of active bleeding or before surgical or invasive procedures. Antithrombin administration is not recommended. Specific platelet transfusion thresholds are based on the presence or absence of bleeding, significant risk for bleeding, plans for surgery or invasive procedures, and platelet count

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“…9,10 Lipopolysaccharide (LPS) stimulation decreases erythropoiesis in rats because of reduced EPO synthesis. 11 However, in patients with septic shock, the endogenous serum EPO concentration is increased, 12,13 apparently independent of the hemoglobin concentration. 13 No relationship or a negative relationship was observed between serum EPO levels and blood hemoglobin concentrations in septic patients.…”

mentioning

confidence: 99%