Circulating Factor VIII Anticoagulant in Bullous Dermatitis

Treatment of a Case of Factor VIII Inhibitor in an Elderly Female

“…Steroids have been used to treat this condition and have been credited with success, but Sherman et al [1969] reported that only about 50% of the non-haemo philiac patients given steroids seem to benefit from them. Indeed a number of cases have been described [Cooke et al, 1962;M ason, 1969; G reen and R iz z a , 1967] were the inhibitor developed while the patient was already on steroids, as was the case with our patient.…”

Acquired Inhibitors in Nonhemophilic Patients

“…[87,125,151]. It is not surprising that steroids are not effective since in many cases the inhibitor developed while the patient received steroids for treat ment of the underlying disease [9,31,65,132,137], Immunosuppressive treatment. Twenty patients (including 4 cases from our own department) have been treated with various immunosuppressive agents, usually combined with small doses of steroids.…”

Laryngeal Epidermolysis Bullosa Acquisita Requiring Tracheostomy Presenting with an Acquired Factor VIII Coagulopathy

“…Because both of these diseases are autoimmune phenomena, it is possible that they share a common cause that is not yet defined. Although this combination has never been reported, there have been previous reports of acquired factor VIII inhibitors in association with other autoimmune dermatologic disorders such as bullous dermatitis 4 and pemphigus vulgaris 5…”