Circulating fatty acid-binding protein 1 (FABP1) and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

Abstract

Background: Fatty acid-binding protein 1 (FABP1) (also known as liver-type fatty acid-binding protein or LFABP) is a protein that is mainly expressed in the liver, and is associated with hepatocyte injury in acute transplant rejection. Reduced levels of FABP1 in mice livers have been shown to be effective against nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the association between plasma FABP1 levels and NAFLD in patients with type 2 diabetes mellitus (T2DM). Methods: We enrolled 267 T2DM patients. Clinical and biochemical parameters were measured. The severity of NAFLD was assessed by ultrasound. FABP1 levels were determined using by enzyme-linked immunosorbent assays. Results: FABP1 levels were higher in patients with overt NAFLD, defined as more than a moderate degree of fatty liver compared to those without NAFLD. Age-and sex-adjusted analysis of FABP1 showed positive associations with body mass index (BMI), waist circumference, homeostasis model assessment estimate of β-cell function, creatinine, and fatty liver index, but showed negative associations with albumin and estimated glomerular filtration rate (eGFR). The odds ratio (OR) for the risk of overt NAFLD with increasing levels of sex-specific FABP1 was significantly increased ). The OR in the second and third tertiles of FABP1 remained significant after adjustments for BMI, triglycerides, high-density lipoprotein cholesterol, HbA1C, homeostasis model assessment estimate of insulin resistance, white blood cell count, hepatic enzymes, and eGFR. Conclusion:Our results indicate that FABP1 may play a role in the pathogenesis of NAFLD in patients with T2DM.

Predicting Nonalcoholic Fatty Liver Disease through a Panel of Plasma Biomarkers and MicroRNAs in Female West Virginia Population

“…Fatty acid-binding proteins (FABPs) secreted from liver coordinate lipid responses in hepatocytes and link various metabolic and inflammatory pathways which include fatty acid uptake, transport, oxidation, lipid synthesis and storage [82]. Cumulative evidence suggests the positive correlation of FABP-1 with obesity, diabetes and NASH [83,84]. In accordance with previous reports, our results showed increased levels of FABP-1 in patients with obesity and diabetes with or without fatty infiltration.…”

Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers

“…After fasting for at least 8 hours, a peripheral blood sample was taken from the worker’s antecubital vein. Complete blood count and serum uric acid, aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose, HbA1c, and lipid panel (including plasma total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides) were also analyzed during the health check, and were determined in all workers using standard commercial methods with a parallel, multichannel analyzer (Hitachi 7170A, Tokyo, Japan) as described in our previous reports [ 20 , 21 ]. Peripheral leukocyte count was analyzed with an automated cell counter (XE-2100 Hematology Alpha Transportation System, Sysmex Corporation, Kobe, Japan).…”

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

“…Studies show that CCR2+ macrophage is a pioneer in the hepatic monocyte uptake; it can induce lipolysis through regulation of epinephrine and norepinephrine levels and promote liver injury [ 78 ]. In T2DM-NAFLD subjects, authors found increased levels of Fatty acid-binding protein 1 (FABP1), a protein that facilitates the storage of FFAs and urges liver damage [ 79 , 80 ]. Some suggested that this protein may be used as a biomarker to detect liver injury [ 81 ].…”