Circulating fatty acids in relation to alcohol consumption: Cross-sectional results from a cohort of 60-year-old men and women

Laguzzi, Federica; Risérus, Ulf; Marklund, Matti; Vikström, Max; Sjögren, Per; Gigante, Bruna; Alsharari, Zayed; Hellénius, Mai-Lis; Cederholm, Tommy; Frumento, Paolo; Fairé, Ulf dé; Leander, Karin

doi:10.1016/j.clnu.2017.09.007

Cited by 15 publications

(9 citation statements)

References 48 publications

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“…Our results show an association between higher alcohol intake and higher 16:0, 16:1 and estimated SCD activity. This is in line with previous studies showing that alcohol consumption is positively associated with 16:0 in plasma PL [32] and in erythrocyte membranes [25,33,34]. As a potential mechanism, alcohol consumption may increase the activity of acetyl-CoA carboxylase, a key lipogenic enzyme, and thereby the synthesis of 16:0 [33].…”

Section: Discussionsupporting

confidence: 92%

Association between carbohydrate intake and fatty acids in the de novo lipogenic pathway in serum phospholipids and adipose tissue in a population of Swedish men

et al. 2019

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Purpose Fatty acid composition in blood and adipose tissue (AT) is a useful biomarker of dietary fat quality. However, circulating saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) have been proposed to also reflect carbohydrate-induced de novo lipogenesis (DNL) and stearoyl-CoA desaturase (SCD) activity. We aimed to test the hypothesis that high carbohydrate intake is related to SFA and MUFA in serum or AT in a Swedish population. Methods Fatty acid composition was measured in serum phospholipids (PL) and AT by gas chromatography in 63-yearold men (n = 299). Carbohydrate and alcohol intake was assessed (validated 7-day food records) in relation to total SFA, 16:0 (palmitate), 16:1 (palmitoleate), and estimated SCD activity (16:1n-7/16:0-ratio) in serum PL and in AT, respectively. Results Total carbohydrate intake was inversely associated with 16:0 in PL (P = 0.005), independently of BMI. Disaccharides were non-linearly (restricted cubic splines) and weakly associated with 16:1 and SCD activity in PL (nonlinear trend, P ≤ 0.02

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Section: Discussionsupporting

confidence: 92%

Association between carbohydrate intake and fatty acids in the de novo lipogenic pathway in serum phospholipids and adipose tissue in a population of Swedish men

et al. 2019

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“…At least six cross-sectional studies observed significant inverse associations between circulating odd-chain SFAs, particularly C17:0, and lipid profiles, markers of inflammation, or glucose metabolism, although these correlations seem to be observed mostly in overweight and obese participants 36,[66][67][68][69][70] . Two cross-sectional studies also suggested potential influences of other nutrients such as alcohol or different dietary patterns on the relationship between circulating odd-chain SFAs and lipid profiles 69,71 . Stronger evidence from well-controlled intervention studies investigating the specific role of odd-chain SFAs is still very limited.…”

Section: Associations With Markers Of Cardiometabolic Healthmentioning

confidence: 99%

Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health? A narrative review

et al. 2022

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In epidemiological studies, dairy food consumption has been associated with minimal effect or decreased risk of some cardiometabolic diseases (CMD). However, current methods of dietary assessment do not provide objective and accurate measures of food intakes. Thus, the identification of valid and reliable biomarkers of dairy intake is an important challenge to best determine the relationship between dairy consumption and health status. This review investigated potential biomarkers of dairy fat consumption, such as odd-chain, trans- and branched-chain fatty acids, which may improve the assessment of full-fat dairy product consumption. Overall, the current use of serum/plasma fatty acids as biomarkers of dairy fat consumption is mostly based on observational evidence, with a lack of well-controlled, dose response intervention studies to accurately assess the strength of the relationship. Circulating odd-chain saturated fatty acids and trans-palmitoleic acid are increasingly studied in relation to CMD risk and seem to be consistently associated with a reduced risk of type 2 diabetes in prospective cohort studies. However, associations with cardiovascular diseases are less clear. Overall, adding less studied fatty acids such as vaccenic and phytanic acids to the current available evidence may provide a more complete assessment of dairy fat intake and minimise potential confounding from endogenous synthesis. Finally, the current evidence base on the direct effect of dairy fatty acids on established biomarkers of CMD risk (e.g. fasting lipid profiles and markers of glycaemic control) mostly derives from cross-sectional, animal, and in vitro studies, and should be strengthened by well-controlled human intervention studies.

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“…Previously, in a cohort of Dutch postmyocardial infarction patients, weak correlations of dietary with circulating LA and lower circulating LA with higher alcohol intakes at similar intakes of LA [45] were reported, which were also observed in the present study. High alcohol intake is an established cause of liver fat accumulation [46] and higher alcohol intake has been associated with lower circulating LA in several crosssectional studies [47][48][49]. It is, therefore, possible that the inverse association between circulating LA and GGT in this study may reflect alcohol influence.…”

Section: Discussionmentioning

confidence: 69%

Associations of linoleic acid with markers of glucose metabolism and liver function in South African adults

et al. 2020

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Background: The relation between dietary and circulating linoleic acid (18:2 n-6, LA), glucose metabolism and liver function is not yet clear. Associations of dietary and circulating LA with glucose metabolism and liver function markers were investigated. Methods: Cross-sectional analyses in 633 black South Africans (aged > 30 years, 62% female, 51% urban) without type 2 diabetes at baseline of the Prospective Urban Rural Epidemiology study. A cultural-sensitive 145-item foodfrequency questionnaire was used to collect dietary data, including LA (percentage of energy; en%). Blood samples were collected to measure circulating LA (% total fatty acids (FA); plasma phospholipids), plasma glucose, glycosylated hemoglobin (HbA1c), serum gamma-glutamyl transferase (GGT), alanine (ALT) and aspartate aminotransferase (AST). Associations per 1 standard deviation (SD) and in tertiles were analyzed using multivariable regression. Results: Mean (±SD) dietary and circulating LA was 6.8 (±3.1) en% and 16.0 (±3.5) % total FA, respectively. Dietary and circulating LA were not associated with plasma glucose or HbA1c (β per 1 SD: − 0.005 to 0.010, P > 0.20). Higher dietary LA was generally associated with lower serum liver enzymes levels. One SD higher circulating LA was associated with 22% lower serum GGT (β (95% confidence interval): − 0.25 (− 0.31, − 0.18), P < 0.001), but only ≤9% lower for ALT and AST. Circulating LA and serum GGT associations differed by alcohol use and locality. Conclusion: Dietary and circulating LA were inversely associated with markers of impaired liver function, but not with glucose metabolism. Alcohol use may play a role in the association between LA and liver function. Trial registration: PURE NorthWest Province South Africa study described in this manuscript is part of the PURE study. The PURE study is registered in ClinicalTrials.gov (Identifier: NCT03225586; URL).

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Circulating fatty acids in relation to alcohol consumption: Cross-sectional results from a cohort of 60-year-old men and women

Cited by 15 publications

References 48 publications

Association between carbohydrate intake and fatty acids in the de novo lipogenic pathway in serum phospholipids and adipose tissue in a population of Swedish men

Association between carbohydrate intake and fatty acids in the de novo lipogenic pathway in serum phospholipids and adipose tissue in a population of Swedish men

Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health? A narrative review

Associations of linoleic acid with markers of glucose metabolism and liver function in South African adults

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