Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals

Akter, Shamima; Nanri, Akiko; Kuwahara, Keisuke; Matsushita, Yushu; Nakagawa, Tohru; Konishi, Maki; Honda, Takeshi; Yamamoto, S.; Hayashi, Takeshi; Noda, Mitsuhiko; Mizoue, Tetsuya

doi:10.1111/jdi.12617

Cited by 34 publications

(29 citation statements)

References 49 publications

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“…Several previous studies have indicated that elevated levels of circulating ferritin are associated with disrupted glucose and lipid metabolism, which is observed in T2DM[14–17], gestational diabetes[18, 19], IR[20, 21], β-cell dysfunction[22], obesity[23–27], dyslipidemia[20], CVD[28, 29], and MetS[3, 30]. This study also showed that subjects with dyslipidemia and diabetes had higher serum ferritin levels than subjects without dyslipidemia and diabetes in both genders.…”

Section: Discussionmentioning

confidence: 99%

“…As an iron-storage protein, serum ferritin is used to evaluate the status of common diseases, such as iron-deficiency anemia [21, 27], and hereditary and acquired iron overload conditions, such as hereditary hemochromatosis, thalassemia, hemoglobinopathy and chronic transfusion therapy [31]. Serum ferritin is also recognized as an acute phase marker of inflammation.…”

Section: Discussionmentioning

confidence: 99%

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Independent relationship between serum ferritin levels and dyslipidemia in Chinese adults: A population study

Jiang

Bao²,

Zhang

et al. 2017

PLoS ONE

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ObjectiveSeveral studies have indicated that elevated levels of circulating ferritin are associated with disturbances in energy metabolism. But none of this gave a clearly pathologic mechanism. We aimed to explore the independent relationship between serum ferritin levels and dyslipidemia.MethodsWe performed multivariable logistic regression analyses to estimate the odds ratios (ORs) for dyslipidemia, lipid parameters, the homeostasis model assessment of insulin resistance (HOMA-IR) and the risk of diabetes, according to sex-specific quartiles of serum ferritin by using the data of China Health and Nutrition Survey (2009 CHNS). We used three models to estimate the strength of the correlation. The basic model (Model 1) is without adjustment and the Model 2 and Model 3 are adjusted for demographic, anthropometric, and lifestyle confounding factors.ResultsIn both genders, the ORs for high TG level, TC level and LDL-C level increased progressively and for HDL-C decreased across the ferritin quartiles (P<0.001 for trend). After adjustment for confounding factors in different logistic regression models, the results remained unchanged. The ORs for the risk of diabetes and high HOMA-IR level in the highest quartile group of serum ferritin levels were significantly increased in Model 1, but after adjustment for lipid parameters, the ORs for the risk of diabetes was decreased from 1.91 (95% CI: 1.37–2.67; P<0.001 for trend) to 1.48 (95% CI: 1.03–2.12; P = 0.036 for trend) in men, and from 5.40 (95% CI: 3.38–8.63; P<0.001 for trend) to 1.43 (95% CI: 0.83–2.43; P = 0.498 for trend) in women, and the ORs for IR was decreased from 1.86 (95% CI: 1.57–2.20; P<0.001 for trend) to 1.25 (95% CI: 1.05–1.50; P = 0.114 for trend) in men, and from 1.93 (95% CI: 1.63–2.28; P<0.001 for trend) to 1.24 (95% CI: 1.01–1.51; P = 0.012 for trend) in women.ConclusionOur results provide evidence that serum ferritin levels are significantly associated with lipid parameters, independent of glucose metabolism disorders and components of metabolic syndrome (MetS). Thus, serum ferritin plays a key role in energy metabolism disorders and may affect glucose metabolism through lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Independent relationship between serum ferritin levels and dyslipidemia in Chinese adults: A population study

Jiang

Bao²,

Zhang

et al. 2017

PLoS ONE

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“…As previously described 38,39 , we identified a total of 357 new-onset T2D cases over a 5-year follow-up period. We randomly selected two controls for each case by using incidence density sampling, which involves matching each case to each risk set from cohort subjects under follow-up at the time of case occurrence 40 .…”

Section: Methodsmentioning

confidence: 99%

Serum amino acid profiles and risk of type 2 diabetes among Japanese adults in the Hitachi Health Study

Chen

Akter

Kuwahara

et al. 2019

Sci Rep

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Amino acids have emerged as novel biomarkers for predicting type 2 diabetes (T2D), but the epidemiologic data linking circulating amino acid profiles with T2D are sparse in Asian populations. We conducted a nested case-control study within a cohort of 4,754 nondiabetic Japanese employees who attended a comprehensive health checkup in 2008–2009 and agreed to provide blood samples. During a 5-year follow-up, incident T2D cases were ascertained based on plasma glucose, glycated hemoglobin, and self-report. Two controls matched to each case on sex, age, and the date of serum sampling were randomly selected by using density sampling, resulting in 284 cases and 560 controls with amino acid measures. High concentrations of valine, leucine, isoleucine, phenylalanine, tyrosine, alanine, glutamate, ornithine, and lysine were associated with an increased risk of incident T2D, in a linear manner. High glutamine concentrations were associated with a decreased risk of incident T2D. Further adjustment for the homeostasis model assessment of insulin resistance attenuated these associations. Overall, these amino acids may be novel useful biomarkers in the identification of people at risk of T2D before overt symptoms. Insulin resistance may account for or mediate the relationship between these amino acids and risk of incident T2D.

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“…In the presence of inflammation, elevated SF may conceal poor iron status [2, 5, 9, 14]. SF has also been identified as a predictor of diabetes [15–18], metabolic syndrome [10, 19] and cardiovascular events [20–22]. The prevention and management of elevated SF is therefore a strategy in the prevention of these conditions [10, 18, 22].…”

Section: Introductionmentioning

confidence: 99%

The association of serum 25-hydroxyvitamin D concentrations with elevated serum ferritin levels in normal weight, overweight and obese Canadians

Munasinghe¹,

Ekwaru²,

Mastroeni³

et al. 2019

PLoS ONE

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In light of the growing body of literature suggesting a beneficial effect of vitamin D on inflammatory response, we hypothesized that vitamin D affects serum ferritin (SF), a biomarker of inflammation. The objective of the present study is to examine the association of serum 25-hydroxyvitamin D [25(OH)D] with elevated SF concentrations indicative of inflammation as no earlier study has done so. Data from 5550 Canadian adults who participated in the 2012/2013 and the 2014/2015 Canadian Health Measures Surveys were analysed. We observed that 9.4% of Canadian adults have elevated SF concentrations and that 35.6% were vitamin D insufficient. Among Canadians with under/normal body weights, those with serum 25(OH)D ≥ 75 nmol/L relative to those with serum 25(OH)D < 50 nmol/L, were substantially less at risk for elevated SF concentrations (OR = 0.24; 95% CI = 0.06, 0.89; p = 0.034). We did not observe this association for overweight and obese Canadians. Canadians of older age, non-white ethnicity, males, those with income above $100,000, those who consumed alcohol, and those with high total cholesterol concentrations and elevated blood pressures were more likely to have elevated SF concentrations. Serum 25(OH)D ≥ 75 nmol/L is likely to provoke anti-inflammatory benefits, but intervention studies that achieve high 25(OH)D concentrations and with long follow up are needed to establish the role of vitamin D on SF.

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Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals

Cited by 34 publications

References 49 publications

Independent relationship between serum ferritin levels and dyslipidemia in Chinese adults: A population study

Independent relationship between serum ferritin levels and dyslipidemia in Chinese adults: A population study

Serum amino acid profiles and risk of type 2 diabetes among Japanese adults in the Hitachi Health Study

The association of serum 25-hydroxyvitamin D concentrations with elevated serum ferritin levels in normal weight, overweight and obese Canadians

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