Circulating Immune complexes (CIC) as marker for disease progress in oral cancer

Jane, C.; Nerurkar, Alka V.; Karjodkar, Freny

doi:10.1007/bf02913327

Cited by 10 publications

(6 citation statements)

References 10 publications

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“…Progressively elevated levels were observed in advanced stages of oral cancer patients and patients with PMDs. 30 From these results it can be concluded that CIC represent the host's physiological and immunological defense response in eliciting specific antibodies upon exposure to most antigenic substances.…”

Section: Discussionmentioning

confidence: 90%

Assessment of serum copper, iron and immune complexes in potentially malignant disorders and oral cancer

Tiwari¹,

David²,

Mahesh³

et al. 2016

Braz. oral res.

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Potentially malignant disorders (PMDs) of oral cavity and oral cancer remain a cause of serious concern despite intensive research and development. Diet and immunity have been identified to play a crucial role as modifying factors in these diseases. Our study intended to explore this relationship by estimating and comparing the serum levels of copper, iron and circulating immune complexes (CICs) in patients diagnosed with PMDs and oral cancer and normal healthy individuals. In this study, 40 histopathologically diagnosed cases of PMDs and oral cancer were included along with 30 healthy controls and 5 ml of venous blood was drawn using venipuncture. Serum estimation of copper, iron and CIC then followed using the colorimetric and spectrophotometric methods. The data obtained was subjected to statistical analysis using one way ANOVA and Pearson's Product-Moment Correlation Test. The mean serum copper level was measured as 138.98 ± 10.13µg/100ml in the PMD group and 141.99 ± 21.44 µg/100ml in the oral cancer as compared to 105.5 + 18.81µ/100ml in the controls. The mean serum CIC levels was highest in the oral cancer (9.65 ± 0.16OD470) followed by the PMD group (0.18 + 0.21 OD470) and least in the control group (0.048 ± 0.02OD470). Whereas, the serum levels of iron showed a significant decrease in the PMD group (110.9 ± 10.54 µg/100ml) and the oral cancer group (114.29 ± 25.83 µg/100ml) as compared with the control group (136.85 ± 14.48 µg/100ml). There was no positive correlation obtained between the three groups with respect to the chosen parameters indicating that the variables were independent of each other. It can be thus be ascertained that trace elements like copper and iron as well as humoral responses (CICs) have a close relationship with PMDs and oral cancers.

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Section: Discussionmentioning

confidence: 90%

Assessment of serum copper, iron and immune complexes in potentially malignant disorders and oral cancer

Tiwari¹,

David²,

Mahesh³

et al. 2016

Braz. oral res.

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“…In most cancers, the disease affected tissues generate tumor specific circulating immune cells. As the tumor grows, more tumor antigens were released which may increase the level of circulating Tm cells ( Jane, Nerurkar & Karjodkar, 2007 ; Pages et al, 2005 ; Parcesepe et al, 2016 ). The Tm cells are important for mounting an immune response against the same tumor antigens if they are encountered again.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of circulating immune cells in left- and right-sided colon cancer

Meng

Yang

et al. 2017

PeerJ

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BackgroundLeft-sided and right-sided colon cancers (LCCs and RCCs, respectively) differ in their epidemiology, pathogenesis, genetic and epigenetic alterations, molecular pathways and prognosis. Notably, immune response gene expression profiles have been shown to differ between patients with LCC and patients with RCC. The immune system plays an important role in tumor immunosurveillance, and there is increasing evidence that peripheral blood immune cells have a profound influence on tumor prognosis. This study aimed to determine the clinical significance of circulating immune cells with respect to colon tumor locations.MethodsDifferent types of circulating immune cells were separated and analysed based on their surface markers by flow cytometry. We compared the numbers of dendritic cells (DCs) and T cell subsets in the peripheral blood of 94 patients with RCC or LCC and analysed the proportions of these immune cells in relation to tumor stage, tumor differentiation and lymphatic metastasis.ResultsWe show that at later tumor stages, patients with LCC had higher levels of circulating myeloid DCs (P = 0.049) and plasmacytoid DCs (P = 0.018) than patients with RCC. In poorly differentiated tumors, LCC patients had significantly higher amount of plasmacytoid DCs (P = 0.036), CD4+ memory T (Tm) cells (P = 0.012), CD4+ T cells (P = 0.028), Tm cells (P = 0.014), and regulatory T cells (P = 0.001) than RCC patients. The levels of circulating CD4+ T cells, Tm cells and CD4+ Tm cells were significantly elevated at later stages in patients with LCC or RCC, while these cells decreased in poorly differentiated tumors in patients with RCC. Moreover, CD4+ Tm cell and CD4+ T cell levels are significantly associated with lymph node metastasis in patients with LCC and RCC.DiscussionCirculating immune cells were associated with tumor location, tumor stage and tumor differentiation, and can be used to predict lymphatic metastasis in patients with colon cancer. This variation in systemic immunity could contribute to the differential prognosis of patients with colon cancer.

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“…Many researchers [34], [35], [37], [38] reported that the antigenic part of CICs originate from the diseased tissues. Release of antigen from these tissues increases as the disease progresses and that may be responsible for increase in the levels of CICs with increasing grades of PCa which is observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

Comparison Between Circulating Immune Complexes and Prostate Specific Antigen to Assess the Pathogenesis of Prostate Cancer

Nerurkar¹

2017

JCTR

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Prostrate cancer is a common cancer in males with increasing rate of incidence these days. Two known markers prostatic acid phosphatase (PAP) and prostate specific antigen (PSA) have been used for diagnosis and in the clinical management of prostate cancer patients. PAP and PSA tests are not specific and hence not reliable. Therefore, certain immunological tests need to be developed to aid the clinicians in early detection, metastasis and recurrence and also to follow clinical course of the disease and/or its response to therapy. The present study shows that the circulating immune complexes (CICs) may be associated with the pathogenesis of prostate cancer and their progression. CICs were investigated in 50 prostate cancer patients having different grades of the disease and 45 benign prostate hyperplasia patients (BPH). Estimation of CICs was done using 3.75% Polyethylene glycol 6000 (PEG) serum precipitation. The results obtained were compared with normal healthy individuals. 83.33% and 91.66% positivity was observed in Grade I and Grade II prostate carcinomas respectively, whereas 100% positivity was observed in Grade III and Grade IV prostate carcinoma. BPH patients showed 60% positivity. Strong positive correlation (r=0.5748) between Prostate specific antigen (PSA) and CIC was observed in prostate cancer patients. Present investigation shows CICs may be associated with the pathogenesis of prostate cancers. The further qualitative analysis of CICs may help us to formulate specific immunological tests for early detection, management and monitoring the efficacy of treatment in prostate cancers.

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Circulating Immune complexes (CIC) as marker for disease progress in oral cancer

Abstract: ABSTRACT

Cited by 10 publications

References 10 publications

Assessment of serum copper, iron and immune complexes in potentially malignant disorders and oral cancer

Assessment of serum copper, iron and immune complexes in potentially malignant disorders and oral cancer

Clinical significance of circulating immune cells in left- and right-sided colon cancer

Comparison Between Circulating Immune Complexes and Prostate Specific Antigen to Assess the Pathogenesis of Prostate Cancer

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