Circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) in head and neck cancer

Liu, C M; Sheen, Tzung‐Shiahn; Ko, Jeng-Juh; Shun, Chia‐Tung

doi:10.1038/sj.bjc.6690057

Cited by 27 publications

(24 citation statements)

References 21 publications

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“…Elevated circulating levels of E-selectin have been reported in oral SCC and may represent a marker of disease presence, although in this particular study there was no correlation between early and late lesions (Liu et al, 1999).…”

Section: Selectins In Oral Carcinomascontrasting

confidence: 49%

Cell Adhesion Molecules and Oral Cancer

Thomas

Speight

2001

Critical Reviews in Oral Biology & Medicine

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Cell adhesion molecules (CAMs) are found on the surfaces of all cells, where they bind to extracellular matrix molecules or to receptors on other cells. As well as having a structural role, CAMs function as signaling receptors, transducing signals initiated by cellular interactions which regulate many diverse processes, including cell division, migration, and differentiation. Cell adhesion molecules are essential for maintaining stable tissue structure. However, cell adhesion must be dynamic to facilitate the mobility and turnover of cells. In dynamic situations, cells alter their cell-cell and cell-matrix interactions by virtue of altered expression and function of CAMs. The expression of CAMs is normally tightly regulated, thereby controlling cell proliferation, mobility, differentiation, and survival. Many of these processes are misregulated in malignant tumors, and it has been shown that many of the characteristics of tumor cells are attributable to the aberrant expression or function of CAMs.Integrins and E-cadherin are the most important CAMs expressed by stratified squamous epithelium. Altered expression of these molecules has been found in oral carcinoma, where loss of CAM expression is often seen in poorly differentiated lesions.However, up-regulation of certain integrins, such as av16, has consistently been found in oral cancer, suggesting that it may play an active role in disease progression.Key words. Oral cancer, cell adhesion molecules, integrins, cadherins, selectins, immunoglobulin superfamily, CD44. (I) IntroductionCell adhesion molecules (CAMs) are found on the surfaces of all cells, where they bind to extracellular matrix molecules or to receptors on other cells. Cell adhesion is critical in the dynamic processes necessary for tissue morphogenesis in development and the maintenance of complex differentiated tissues in adult organisms. CAMs serve in these roles by virtue of their capacity to connect the exterior of the cell with the interior. They form structural linkages between the cell cytoskeleton and the extracellular matrix or between cells, and also function as signaling receptors, transducing signals initiated by cellular interactions which regulate many diverse processes, including cell division, migration, and differentiation ( Fig. 1).Cell adhesion molecules are essential for maintaining the stable structure of stratified squamous epithelium. In normal epithelium, keratinocytes are attached to each other and to the underlying basement membrane. Cell adhesion, however, must be dynamic to facilitate the mobility and turnover of cells. In dynamic situations, keratinocytes alter their cell-cell and cell-ECM interactions by virtue of altered expression and function of CAMs.The expression of cell adhesion molecules is normally tightly regulated-forming, persisting, or declining in an ordered fashion. This allows for controlled cell proliferation, mobility, differentiation, and survival. Many of these processes are misregulated in malignant tumors, and it has been shown that man...

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Section: Selectins In Oral Carcinomascontrasting

confidence: 49%

Cell Adhesion Molecules and Oral Cancer

Thomas

Speight

2001

Critical Reviews in Oral Biology & Medicine

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“…With this finding, we concluded that VEGF may not be used as a prognostic factor, but further studies are needed to confirm the results. Recently conducted studies revealed the importance of adhesion process in tumor biology [17]. The existence of adhesion molecules in circulation has been shown in head and neck carcinomas [15][16][17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

“…The possible roles of soluble adhesion molecules in the prognosis of head and neck carcinoma deserve further elucidation and evaluation. However, some studies show that the level of circulating adhesion molecules such as VCAM is higher in cancer patients than in the normal population [15][16][17][18][19][20][21].…”

mentioning

confidence: 99%

“…Adhesion molecules such as vascular cell adhesion molecule (VCAM), intercellular adhesion molecule (ICAM), and N-CAM like adhesion molecule have been described [15][16][17][18][19][20][21]. All of these molecules are thought to play a role in tumor invasiveness and tumor aggression but the mechanism of this function is still not clear [15][16][17][18][19][20][21]. Adhesion molecules are believed to take part in the process of metastasis but here again the exact mechanism is not clear.…”

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confidence: 99%

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Prognostic value of soluble factors of angiogenesis and adhesion processes in head and neck squamous cell carcinomas

Gün¹

2018

Ann Clin Anal Med

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Aim: In this study, we aimed to define the prognostic value of two factors related to angiogenesis and adhesion processes of head and neck squamous cell carcinomas. The prominent angiogenesis molecule is vascular endothelial growth factor (VEGF). The vascular cell adhesion molecule (VCAM) first attracted attention more than two decades ago as endothelial adhesion receptor with key function for leukocyte recruitment in term of cellular immune response. Material and Method: 35 patients with head and neck squamous cell carcinomas were enrolled in this study. The control group consisted of 20 people who had no sign of regional or systemic diseases. 33 patients were male and 2 patients were female. Mean age was 59.7 years (28-76). Results: We showed that VEGF levels in the patient group were significantly higher than in the control group (p=0.001). However, when comparing the VEGF levels of different stages, there was no statistical significant difference between the stages. Discussion: Serum VEGF levels can provide sufficient information for the early diagnosis of the disease but prognosis may not be evaluated according to the results of our study. VCAM levels were not specific and sensitive to use as a tumor marker but VCAM may be a valuable factor to determine the prognosis and tumor aggression in cancer patients.

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“…Disease sICAM-1 shows a significant elevation in the sera of patients with nasopharyngeal carcinoma compared to healthy controls (Liu et al, 1999).…”

Section: Head and Neck Cancermentioning

confidence: 99%