Circulating Interleukin 16 (IL‐16) in children with atopic/eczema dermatitis syndrome (AEDS): a novel serological marker of disease activity

Frezzolini, Alessandra; Paradisi, Mauro; Zaffiro, Alessandra; Provini, Alessia; Cadoni, S.; Ruffelli, M.; Pità, Ornella De

doi:10.1034/j.1398-9995.2002.23687.x

Cited by 45 publications

(34 citation statements)

References 35 publications

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“…It is possible that IL-16 secreted from peripheral eosinophils may accelerate chronic inflammation at the nasal mucosa by activating T lymphocytes and eosinophils themselves in allergic rhinitis. However, several reports have shown that circulating IL-16 is produced mainly from T cells at the inflammatory site in allergic disease with eosinophilia [6, 23]. It remains unclear which source of IL-16 primarily contributes to pathogenesis in allergic rhinitis.…”

Section: Discussionmentioning

confidence: 99%

Expression of Interleukin-16 in Allergic Rhinitis

Karaki

Dobashi²,

Kobayashi³

et al. 2005

Int Arch Allergy Immunol

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Background: Interleukin-16 (IL-16) has been characterized as a chemoattractant for a variety of CD4+ T cells. Several inflammatory diseases, including allergic disorders, have been reported to correlate with IL-16. We first examined the IL-16 expression of serum and mucosal tissue in patients with allergic rhinitis. Methods: Forty-eight patients with a clinical history of house dust mite (HDM) or pollen-sensitive allergic rhinitis were included in this study. Serum IL-16 was analyzed by enzyme-linked immunosorbent assay (ELISA). IL-16 expression of nasal mucosa was detected by immunohistochemistry. Results: IL-16 levels were elevated in the serum of patients with allergic rhinitis compared with normal controls. In particular, serum IL-16 levels in HDM-sensitive patients were higher than those in pollen-sensitive patients. IL-16 was significantly correlated with eosinophils in the peripheral blood of allergic rhinitis patients. Histologically, IL-16 was expressed in infiltrated lymphocytes and nasal gland cells. Conclusions: Our data indicate that one of the sources of elevated serum IL-16 in allergic patients may be gland cells and lymphocytes in allergic nasal mucosa. This IL-16 cytokine may be strongly associated with the developmental mechanism of allergic rhinitis.

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Section: Discussionmentioning

confidence: 99%

Expression of Interleukin-16 in Allergic Rhinitis

Karaki

Dobashi²,

Kobayashi³

et al. 2005

Int Arch Allergy Immunol

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“…In acute skin lesions, the predominance of Th2 lymphocytes that produce IL-4 and IL-13 is replaced by Th1 lymphocytes with predominant IFN-γ production in the chronic phase of AD [9,12]. Previous studies also demonstrated impaired Th1 and dominant Th2 cytokine expression in both CD4+ and CD8+ T cells in peripheral blood of AD patients [8].…”

Section: Discussionmentioning

confidence: 92%

“…Among chemotactic factors, interleukin (IL)-16 has been fully characterized as an immunomodulatory cytokine, playing a role in the recruitment of CD4-expressing Th cells, monocytes and eosinophils to the site of inflammation. Besides its chemotactic properties, IL-16 can trigger IL-2 receptor α-chain expression and activate CD4+ T cells in synergy with IL-2 or IL-15 [9]. In addition, IL-16 amplifies the inflammatory reactions by stimulating cytokine production in monocytes and maturing macrophages [10].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, IL-16 seems to be a proper marker for measuring AD activity [2,4,9], although little is known about the correlation between serum IL-16 levels and the degree of allergic sensitization. The aims of this study were to (1) assess serum levels of IL-16 in patients with AD and nonatopic healthy controls and (2) analyze the possible correlation between IL-16 and several markers, reflecting the state of sensitization within these patients.…”

Section: Introductionmentioning

confidence: 99%

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Association between Serum IL-16 Levels and the Degree of Sensitization in Patients with Atopic Dermatitis

Nagy

Gáspár

Irinyi

et al. 2011

Int Arch Allergy Immunol

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Background: Interleukin (IL)-16 has been characterized as an immunomodulatory cytokine. Besides its chemotactic properties, IL-16 amplifies inflammatory processes and possesses immunoregulatory functions. Our aim was to investigate the association between serum IL-16 levels and the degree of allergic sensitization in patients with atopic dermatitis (AD). Methods: The serum level of IL-16 was measured by immunoenzymatic assays. Eosinophil cell count, serum total and specific IgE levels were assessed; prick tests were also carried out. Based on specific IgE levels and prick tests, AD patients were divided into sensitized and nonsensitized subgroups, and correlations among serum IL-16, total IgE levels and eosinophil cell counts were measured in the total patient group and in subgroups. Results: In the total patient group, significantly higher levels of IL-16 were found in the sera of patients with AD, compared to healthy individuals and patients with psoriasis. A significant correlation was detected between serum levels of IL-16 and total IgE, total IgE and eosinophil counts, but not between IL-16 and eosinophils. When sensitized and nonsensitized subgroups were compared, IL-16 levels showed a significant difference in subgroups that were divided based on specific IgE measurements, but not in those subgroups which were divided based on prick tests. On the other hand, serum total IgE levels showed a significant difference between sensitized and nonsensitized subgroups, assessed by the specific IgE method and also by prick test. Conclusion: Serum IL-16 levels of AD patients correlate to some extent with sensitization. This correlation is not as strong as the correlation between total IgE levels and allergic sensitization.

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“…The high expression of CD86 on B cells in AD (72) might provide costimulatory signals via CD28 on T cells, resulting in the production of large amounts of IL-5 and IL-13 in AD (73). Moreover, activated B cells produce the chemokines CCL17 (TARC), CCL22 (MDC) and IL-16 and thus may recruit other immune cells into the skin (74,75). The depletion of B cells with rituximab, an anti-CD20 antibody, resulted in a rapid reduction in skin inflammation in all patients with a sustained effect over 5 months in five of six patients (76).…”

Section: Targeting B Cells and Igementioning

confidence: 99%

Atopic dermatitis - from new pathophysiologic insights to individualized therapy

Novak

Simon

2011

Allergy

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Circulating Interleukin 16 (IL‐16) in children with atopic/eczema dermatitis syndrome (AEDS): a novel serological marker of disease activity

Abstract: We suggest that IL-16 could serve as a useful marker of disease activity in childhood pAEDS.

Cited by 45 publications

References 35 publications

Expression of Interleukin-16 in Allergic Rhinitis

Expression of Interleukin-16 in Allergic Rhinitis

Association between Serum IL-16 Levels and the Degree of Sensitization in Patients with Atopic Dermatitis

Atopic dermatitis - from new pathophysiologic insights to individualized therapy

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