Circulating irisin levels in newly diagnosed obstructive sleep apnea patients

Öztürk, Gülnur; Demirel, Ozlem Unay; Tekatas, Aslan; Celebi, Canan; Avci, Bengu; Gürel, Elif Ezgi; Yüksel, Meral; Öztürk, Levent

doi:10.14748/ssm.v51i1.5908

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Circulating irisin levels are positively associated with endothelium-dependent arterial dilation in diabetic patients (31). Whereas elevated circulating irisin level was suggested to have role in the development of insuline resistance and atherosclerosis in patients with obstructive sleep apnea (32). Altogether, these data collectively suggest that diabetes and related CMD might, at least in part, be viewed as irisin-mediated disorders (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42).…”

Section: Irisinmentioning

confidence: 99%

Adipomyobiology Of Obesity And Related Diseases: Therapy Insights

Chaldakov

Aloe²,

Vinciguerra

et al. 2021

Adipobiology

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Today, the most widespread disease around the world is not COVID-19 or any other communicable disease. Indeed, obesity and type 2 diabetes mellitus (T2DM) have been recognized as the main risks for cardiometabolic diseases (CMD) and their morbidity and mortality signature. Recent studies revealed that the adipose tissue and the skeletal muscles may function as endocrine and paracrine organs secreting multiple proteins termed adipokines and myokines respectively. Some of them being produced both by adipose and skeletal tissue, hence dubbed adipomyokines. The contents of this review highlights the following two topics: (i) the progress in knowledge of adipomyokines may lead to better understandings of the process of pathogenesis of obesity and related CMD, and (ii) in-depth studies on Palade-Blobel's general theory of cell protein secretion may allow to explore its pharmacological potentials for new therapies of these diseases. This may open up an intriguing line of scientific enquiry that will unite adipobiologists and myobiologists in the fight against obesity and related CMD.

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Section: Irisinmentioning

confidence: 99%

Adipomyobiology Of Obesity And Related Diseases: Therapy Insights

Chaldakov

Aloe²,

Vinciguerra

et al. 2021

Adipobiology

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COVID-19: Could Irisin Become the Handyman Myokine of the 21st Century?

Catalano

2020

COVID

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: The ongoing Coronavirus disease 2019 (COVID-19) outbreak in China has become the world's leading health headline and is causing major panic and public concerns. After emerging in the City of Wuhan, China, COVID-19 has spread to several countries becoming a worldwide pandemia. Among the studies on COVID-19 it has been demonstrated that novel coronavirus pneumonia is closely associated with inflammatory storms. Controlling the inflammatory response may be as important as targeting the virus. Irisin is a muscle-contraction-induced immunomodulatory myokine related to physical activity. Irisin drives the “browning” of white adipocytes, so enhancing metabolic uncoupling and hence caloric expenditure. Irisin has been clearly shown to be a handyman molecule by exerting beneficial effects on adipose tissues, pancreas, and bone through “cross-talk” between skeletal muscle-adipocyte, skeletal muscle-pancreas, and skeletal musclebone, respectively. Irisin has been proposed as a promising strategy for early diagnosis and treatment of a various types of cancers, neurological diseases and inflammatory conditions. Irisin has been demonstrated to suppress the immune response, too. The importance of irisin is demonstrated by the increase in the number of scientific papers and patents in recent years. The identification of irisin receptor should greatly facilitate the understanding of irisin’s function in exercise and human health. This review examines the structure and recent advances on activities of irisin, suggesting it for further studies for the prevention and cure of COVID-19. Nowadays, studies on irisin plasma levels and physical activity may be useful tools to further investigate prevention of COVID-19. Irisin may be suggested as a potential novel intervention for COVID-19 by mitigating inflammatory storms, suppressing immune response and simultaneously alleviating neurological disorders such as depression and anxiety.

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Circulating irisin levels in newly diagnosed obstructive sleep apnea patients

Cited by 2 publications

References 19 publications

Adipomyobiology Of Obesity And Related Diseases: Therapy Insights

Adipomyobiology Of Obesity And Related Diseases: Therapy Insights

COVID-19: Could Irisin Become the Handyman Myokine of the 21st Century?

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