Circulating leptin and its correlation with rheumatoid arthritis activity: a meta-analysis

Abstract

The aim of the study was to investigate the association between the levels of leptin in the circulating of individuals with rheumatoid arthritis (RA) and the severity of the disease. Methods: We looked through the databases of Embase, Medline, and the Cochrane Library. We conducted a meta-analysis on the correlations between circulating leptin and the Disease Activity Score 28-erythrocyte sedimentation rate (DAS28-ESR) and Creactive protein (CRP) levels in RA patients, as well as a meta-analysis of circulating or circulating leptin levels in RA patients. Results: This meta-analysis study analyzed 42 different comparisons from 37 different publications, including a total of 2,350 patients with RA and 1,815 controls. The RA group had substantially higher leptin levels than the control group (standardized mean difference [SMD]=0.507, 95% confidence interval [CI]=0.309~0.704, p<0.001). The finding that RA patients had higher leptin levels was unaffected by sample size. The correlation between circulating leptin levels and DAS28 is statistically significant (correlation coefficient=0.247, 95% CI=0.087~0.396, p=0.003). Leptin levels are also correlated with CRP levels (correlation coef-ficient=0.203, 95% CI=0.048~0.349, p=0.010). Conclusion:This comprehensive meta-analysis demonstrates that the circulating leptin levels of RA patients are elevated, and provides compelling evidence of the significant relationship between leptin levels and the activity of RA. The findings of this research suggest that leptin plays a significant role in the pathophysiology of this disease.

Associations between blood IL-33 levels and IL-33 gene polymorphisms with susceptibility to systemic lupus erythematosus: A meta-analysis

“…Additionally, in comparison to individual research, our study was able to provide reliable data because the findings of several independent analyses were combined, increasing the statistical power and resolution of the analysis. [28][29][30] In conclusion, our meta-analysis provides evidence that the IL-33 rs1891385 polymorphism and susceptibility to SLE, as well as blood IL-33 levels and the risk of SLE, are related. Our findings highlight the significance of genetic variables in the etiology of SLE and suggest that IL-33 is a promising biomarker for the diagnosis and monitoring of SLE.…”

“…Additionally, in comparison to individual research, our study was able to provide reliable data because the findings of several independent analyses were combined, increasing the statistical power and resolution of the analysis. 28–30…”

The role of NLRP3 and CARD8 polymorphisms in the risk of rheumatoid arthritis: A meta‐analysis of genetic association studies

“…By analyzing the findings of multiple studies using a meta-analytic approach, our analysis provided a more precise assessment of the total impact size and a more accurate measurement of the relationship between genetic variation and illness. 26,27 According to our meta-analysis, there was no significant association between NLRP3 and CARD9 polymorphisms and susceptibility to RA. Although this suggests that these genetic variations have little effect on the risk of RA, it is important to recognize the limitations of our study and the complexity of RA as a disease.…”

Circulating leptin level in osteoarthritis and associations between leptin receptor polymorphisms and disease susceptibility: A meta‐analysis

“…2 The hormone leptin, which is produced from adipose tissue, controls metabolism and energy balance. 3,4 However, it has been postulated that it contributes to the onset and development of OA stages. [5][6][7] Previous studies have shown that patients with OA had greater levels of circulating leptin than healthy individuals, suggesting a potential association between leptin and OA.…”

“…The breakdown of cartilage in OA is thought to be caused by a combination of physical stress, inflammation, and abnormal metabolism 2 . The hormone leptin, which is produced from adipose tissue, controls metabolism and energy balance 3,4 . However, it has been postulated that it contributes to the onset and development of OA stages 5–7 .…”