Circulating leukocyte telomere length and oxidative stress: A new target for statin therapy

Habitual physical exercise has beneficial effects on telomere length in postmenopausal women

“…2,5 However, a recent study showed that telomere length in PBMCs reduced with age in older participants (mean age, 77 T 7 y) but did not diminish with age in younger participants (mean age, 53 T 7 y). 59 These results are similar to the results found in this study. In addition, this study did not directly measure skeletal muscle for the evaluation of telomere length or mtDNA content.…”

Carbon Monoxide Protects Against Ischemia-reperfusion Injuryin Vitrovia Antioxidant Properties

“…Studies indicated that lipoic acid scavenges hydroxyl radicals, hypochlorous acid and singlet oxygen. In our Laboratory, where we have developed several projects in the field of oxidative stress associated with cardiovascular disease [40][41][42][43][44], we also observed that lipoic acid was able to diminish the superoxide-driven oxidation of a sensitive spin probe, in a manner comparable to that of superoxide dismutase; this effect being not noted with all the antioxidant agents [45]. It can be stated that the sites of reaction of antioxidant agents are not always the same.…”

Changes in markers of oxidative stress and DNA damage in human visceral adipose tissue from subjects with obesity and type 2 diabetes

“…Recent studies by Moreno-Navarrete et al [25] and Monickaraj et al [26], looked at the measurement of telomere length in adipose tissue reporting shortened telomeres in subjects with obesity and diabetes. A significantly high percentage of subjects in the ODM group were receiving statin treatment, which has been observed to have a positive impact on telomere length, showing a protective effect against oxidative stress [27].…”