Circulating level and tissue distribution of sclerostin in calcified mitral valves of rheumatic heart disease

Mukhopadhyay, Saibal; Bhauwala, Amit; Saran, Ram Kirti; Yusuf, Jamal; Subberwal, Manju; Betigeri, Vithalkumar Malleshi; Tyagi, Sanjay

doi:10.1016/j.ihj.2017.09.212

Cited by 3 publications

(3 citation statements)

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“…Its levels are correlated with increased risk for myocardial infarction and cerebral episodes 15 . It inhibits ectopic calcification in the mitral valve in rheumatic disease 16 . Lower fet-A concentrations are associated with more extensive vascular atherosclerosis lesions 17 , and faster stenosis progression and increased valvular calcification in elderly patients with aortic stenosis 18 .…”

Section: Introductionmentioning

confidence: 99%

Serum and tissue biomarkers in aortic stenosis

Kapelouzou

Tsourelis

Kaklamanis

et al. 2015

Global Cardiology Science and Practice

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Background: Calcific aortic valve stenosis (CAVS) is seen in a large proportion of individuals over 60 years. It is an active process, influenced by lipid accumulation, mechanical stress, inflammation, and abnormal extracellular matrix turnover. Various biomarkers (BMs) are studied, as regards mechanisms, diagnosis and prognosis. Methods: In the calcified valves calcium deposition, elastin fragmentation and disorganization of cellular matrix were assessed, together with expression of OPN, OPG, osteocalcin (OCN) and RL2.We prospectively studied the following serum BMs in 60 patients with CAVS and compared them to 20 healthy controls, free from any cardiac disease: Matrix metalloproteinases (MMP) 2 and 9 and tissue inhibitor of metalloproteinase 1 (TIMP1), which regulate collagen turnover, inflammatory factors, i.e. tumor necrosis factor a (TNFa), interleukin 2 (IL2), transforming growth factor β1 (TGF-β1) which regulates fibrosis, fetuin-A (fet-A), osteopontin (OPN), osteoprotegerin (OPG), sclerostin (SOST), and relaxin-2 (RL2) which positively or negatively regulate calcification. Monocyte chemoattractant protein 1 (MCP-1) which regulates migration and infiltration of monocytes/macrophages was also studied as well as malondialdehyde (MDA) an oxidative marker. Results: Extent of tissue valve calcification (Alizarin Red stain) was negatively correlated with tissue elastin, and RL2, and positively correlated with tissue OCN and serum TIMP1 and MCP-1 and negatively with MMP9.Tissue OCN was positively correlated with OPN and negatively with the elastin. Tissue OPN was negatively correlated with elastin and OPG. Tissue OPN OPG and RL2 were not correlated with serum levels In the serum we found in patients statistically lower TIMP1, fet-A and RL2 levels, while all other BMs were higher compared to the healthy group. Positive correlations between SOST and IL2, OPG and MDA but negative with TNFa and OPN were found; also MMP9 was negatively correlated with TNFa and MCP-1 was negatively correlated with TIMP1. Conclusion: We found that many BMs expressing calcification, collagen breakdown, or formation, and inflammation are increased in the valve tissue and in the serum of patients with CAVS as compared with healthy group. Our findings may give new insights towards diagnosis but also therapy. Thus antisclerostin, and antiflammatory agents could be tried for preventing aortic calcification progression.

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Section: Introductionmentioning

confidence: 99%

Serum and tissue biomarkers in aortic stenosis

Kapelouzou

Tsourelis

Kaklamanis

et al. 2015

Global Cardiology Science and Practice

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“…Extensive research over last 25 years has identified CD 4 + T effector cells to be the predominant cells infiltrating the valves16, 17, 18, 19 and we 20 along with others 21 have shown that the degree of infiltration by mono-nuclear cells is proportional to the severity of calcification. Hence in our study the total Wilkins score was significantly higher in patients with calcified valves compared to non-calcified valves.…”

Section: Discussionmentioning

confidence: 87%

Evaluation of serum 25-hydroxyvitamin D levels in calcific rheumatic mitral stenosis— A cross sectional study

Yusuf¹,

Jothinath²,

Mukhopadhyay³

et al. 2018

Indian Heart Journal

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“…As a result, it leads to thickening of mitral valve leaflets, commissural fusion, shortening of chordae and mitral stenosis [14]. Furthermore, it has been shown that RMS patients with calcification have lower levels of fetuin-A, which is an inhibitor of ectopic calcification, in comparison to the normal population [15].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Wilkins echocardiographic score and neutrophil to lymphocyte ratio in patients with rheumatic mitral stenosis

Erkal¹,

Bayar²

2020

Turk J Bioch

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Romatizmal mitral darlığı (RMS) olan hastalarda Wilkins ekokardiyografik skoru (WS) perkütan mitral balon valvuloplastiye (PMBV) uygunluğu değerlendirmede yaygın olarak kullanılmaktadır. WS 11'den yüksek olanlar PMBV için uygun kabul edilmemektedir. Daha önceki çalışmalarda RMS' un ilerlemesinde inflamasyonun rolü gösterilmiştir. Bu çalışmada inflamasyonun göstergelerinden olan nötrofil/lenfosit oranının (NLR) yüksek WS' nu göstermedeki rolü araştırıldı. GEREÇ ve YÖNTEMLER: Bu retrospektif çalışmaya orta-ciddi RMS olan hastalar alındı. Hastaların transtorasik ve transözefageal ekokardiyografik görüntüleri incelendi.Hastalar WS' na göre iki gruba ayrıldı; grup 1'de WS≤ 11 olanlar, grup 2'de WS>11 olanlar. Grupların ekokardiyografik ve hematolojik parametreleri karşılaştırıldı. BULGULAR: Çalışmaya 93'ü kadın (%80) 115 hasta alındı. Grup 1'de 72 hasta (ortalama yaş 43.7±12.0) ve grup 2'de 43 hasta (ortalama yaş 52.7±11.3) vardı. Grup 1'de ortalama WS 7.4±2.0 iken grup 2'de 12.4±0.7 idi. NLR değeri grup 2'de grup 1'den anlamlı olarak daha yüksek saptandı (sırasıyla 3.8±0.5 ve 2.6±0.9, p<0.001). NLR için 3.09 sınır değeri yüksek WS' nu göstermede %100 duyarlılık ve %78 özgüllüğe sahip bulundu. SONUÇ: RMS' lu hastalarda NLR değeri WS>11 olması ile bağımsız ilişkilidir.

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Circulating level and tissue distribution of sclerostin in calcified mitral valves of rheumatic heart disease

Cited by 3 publications

References 0 publications

Serum and tissue biomarkers in aortic stenosis

Serum and tissue biomarkers in aortic stenosis

Evaluation of serum 25-hydroxyvitamin D levels in calcific rheumatic mitral stenosis— A cross sectional study

Relationship between Wilkins echocardiographic score and neutrophil to lymphocyte ratio in patients with rheumatic mitral stenosis

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