Circulating level of interleukin-6 in relation to body mass indices and lipid profile in Egyptian adults with overweight and obesity

El-Mikkawy, Dalia M. E.; EL-Sadek, Maha A.; EL-Badawy, Mohja A.; Samaha, Dalia

doi:10.1186/s43166-020-00003-8

Cited by 60 publications

(50 citation statements)

References 36 publications

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“…The results are in agreement with the findings of other study 17 . Another same finding was observed in healthy children with associated overweight, cardiac problems due to higher circulating IL-6 18 .…”

Section: Discussionsupporting

confidence: 94%

Serum Interleukin-6 and Lipid Atherogenic Index Risk Ratios as Interpreters of Cardiac Disease in Obese and Non Obese Male Patients of Coronary Artery Disease

Naz¹,

Raza²,

Akbar³

et al. 2021

PJMHS

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Aim: To evaluate serum Interleukin-6, and lipids as predictors of cardiovascular diseases (CVD) in obese and non obese male patients of coronary artery disease (CAD). Methodology: It was cross-sectional comparative study. Serum Interleukin-6 and lipid profile was determined in non diabetic, non smoker and non hypertensive age matched obese and non obese male patients of CAD and healthy subjects. Sixty male subjects were divided equally into groups. Group 1, healthy controls (n=20), group 2, non obese male patients with CAD (n=20) and group 3 included Obese male patients with CAD (n=20). The serum was assayed for lipid profile and interleukin-6 . Results: Age matched healthy and patients were non diabetics, non hypertensive and non smoker with altered lipid profile in obese and non obese male patients with coronary artery disease. Patients have high serum cholesterol, low density cholesterol(LDL-C), Triglyceride(TG,) very low density lipoprotein(VLDL) and interleukin-6. The High density lipoprotein was lowered in both obese and non obese male patients with CAD. Significant positive correlation was observed in CAD group of IL-6 with TC (rho= 0.405, p= 0.009*) , with TG (rho= 0.639, p= 0.000*) ,with LDL (rho= 0.398, p= 0.002*), with VLDL (rho= 0.315, p= 0.014*). Significant negative correlation was observed in CAD group of IL-6 with HDL (rho= -0.565, p= 0.000*) Significant positive correlation was observed in CAD group of IL-6 .Significant positive correlation of IL-6 was observed with AI (rho= 0.602, p= 0.000*). Conclusion: Dyslipidemia, Raised interleukin-6 and strong positive correlation of Atherogenic index with IL-6 are independent risk factors for CVD; using Atherogenic risk ratios as a screening tool for the estimation of CVD risk is useful in patients with CAD. Keywords: Lipid profile, serum interleukin-6,Atherogenic index,coronary artery disease.

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Section: Discussionsupporting

confidence: 94%

Serum Interleukin-6 and Lipid Atherogenic Index Risk Ratios as Interpreters of Cardiac Disease in Obese and Non Obese Male Patients of Coronary Artery Disease

Naz¹,

Raza²,

Akbar³

et al. 2021

PJMHS

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“…IL-6 is a cytokine acting on the hepatocytes to induce the production of CRP and fibrin [32]. Approximately 35% of IL-6 is secreted by adipose tissue and the level of IL-6 is increased as BMI increases [33,34]. Therefore, it is logical that overweight individuals who consumed yogurt may have a somewhat stronger reduction in IL-6 compared with their normal weight counterparts.…”

Section: Discussionmentioning

confidence: 99%

Yogurt Consumption Is Associated with Lower Levels of Chronic Inflammation in the Framingham Offspring Study

2021

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Some studies suggest that dairy foods may be linked with less chronic inflammation. However, few studies have investigated the separate effects of different types of dairy on inflammation. Therefore, the current study aims to examine the separate prospective impacts of milk, yogurt and cheese on biomarkers of chronic inflammation in 1753 community-dwelling participants of the Framingham Offspring Study (FOS). Mean intakes of dairy foods were derived from two sets of three-day diet records. Six inflammatory biomarkers were assessed approximately seven years later at exam 7. Results showed that those who consumed yogurt (vs. those who did not) had statistically significantly lower levels of interleukin-6 (IL-6) (mean log-transformed levels of 1.31 and 1.26 in consumers/non-consumers, respectively, p = 0.02) and fibrin (mean log-transformed levels of 5.91 and 5.89 in consumers/non-consumers, respectively, p = 0.03). The inverse association between IL-6 and yogurt consumption was similar in participants who were of normal weight and those who were overweight. For fibrin, the effects were stronger in overweight individuals. No statistically significant associations were observed between any of these inflammation biomarkers and milk or cheese intakes. Overall, our study compared the separate impacts of three types of dairy foods on chronic inflammation and found that only yogurt intake was linked with lower levels of chronic inflammation.

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“…Obesity is also characterised by a pro-inflammatory status of more reduced intensity, but chronic, termed metabolic inflammation, in which the activated monocytes infiltrate the adipose tissue, and differentiate into resident adipose macrophages which in turn secrete inflammatory cytokines, among which IL-6 [ 29 ]. Consequently, obese patients have increased IL-6 values, which results in an increased risk of cardiovascular diseases, insulin resistance, and diabetes mellitus [ 30 ]. These data are confirmed by the results of our study, where the IL-6 level in obese patients was indeed correlated with coronary macrovascular disease.…”

Section: Discussionmentioning

confidence: 99%

The Role of IL-6 and ET-1 in the Diagnosis of Coronary MicroVascular Disease in Women

Gurzau

Sitar-Tăut

Caloian

et al. 2021

JPM

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Background: Microvascular angina is a common clinical entity, with about a three-fold higher frequency in women. The pathogenesis of microvascular angina has not been much studied, but inflammation and endothelial dysfunction have been incriminated as the main mechanisms of this disease. Methoss: Our purpose was to analyze whether certain inflammatory markers, i.e., interleukin 6 (IL-6) and endothelin 1 (ET-1), can play a role in the diagnosis of microvascular angina in women. Results: Ninety women with ischemic heart disease were divided into two groups, based on their affliction with either microvascular or macrovascular disease. In general, the levels of IL6 and ET1 were similar between the two groups. Analyzing these marker levels according to the number of coronary lesions, we obtained an increased IL6 value that was similar for patients with microvascular angina, one-vessel, and two-vessel coronary disease, but significantly lower than in women with three-vessel coronary lesions. Also, in microvascular angina, IL6 level was correlated with the NYHA IV functional class. Unexpectedly, the level of ET1 was correlated with left ventricular systolic dysfunction. Conclusions: In women with an increased suspicion of microvascular angina, in whom microvascular dysfunction cannot be tested invasively, IL-6 level, unlike the ET-1 level, might be considered a diagnostic marker of this disease.

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Circulating level of interleukin-6 in relation to body mass indices and lipid profile in Egyptian adults with overweight and obesity

Cited by 60 publications

References 36 publications

Serum Interleukin-6 and Lipid Atherogenic Index Risk Ratios as Interpreters of Cardiac Disease in Obese and Non Obese Male Patients of Coronary Artery Disease

Serum Interleukin-6 and Lipid Atherogenic Index Risk Ratios as Interpreters of Cardiac Disease in Obese and Non Obese Male Patients of Coronary Artery Disease

Yogurt Consumption Is Associated with Lower Levels of Chronic Inflammation in the Framingham Offspring Study

The Role of IL-6 and ET-1 in the Diagnosis of Coronary MicroVascular Disease in Women

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