Circulating levels of CTRP3 in patients with type 2 diabetes mellitus compared to controls: A systematic review and meta-analysis

Najafi, Mohammad; Sharma, Tanmay; Fallah, Soudabeh; Koushki, Mehdi; Peterson, Jonathan M.; Meyre, David; Fadaei, Reza

doi:10.1016/j.diabres.2020.108453

Cited by 14 publications

(15 citation statements)

References 32 publications

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“…We determined a significant effect of diastolic blood pressure, CHF, glucose, the presence of type 2 DM and obesity on the content of CTRP 3. The results do not contradict the literature, according to which it was determined that there is a negative relationship between CTRP3 concentration and the presence of type 2 DM, BMI and article [7].…”

supporting

confidence: 61%

Assessment of Re-Hospitalization Probability in Patients With Post-Infarction Cardiosclerosis and Comorbid Pathology

Koteliukh

2021

Scientific and practical journal

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Abstract. The aim of our research was to examine the risk factors for re-hospitalization in patients with acute myocardial infarction with concomitant diabetes mellitus (DM) 2 type or obesity. Materials and methods. The research involved examination of 262 patients with post-infarction cardiosclerosis in combination with type 2 DM or obesity. They were divided into groups: Group 1 included 96 patients who were not hospitalized for 12 months; comparison group 2 consisted of 166 patients who were hospitalized to an in-patient department. The average age of the first group was 65.13±1.43 years, the comparison group – 63.47 ± 1.28 years. Patients were divided into 3 groups to assess the value of CTRP 3 in chronic heart failure (CHF): Group 1 included 80 patients with post-infarction cardiosclerosis without type 2 DM or obesity, Group 2 consisted of 74 patients with post-infarction cardiosclerosis with type 2 DM, Group 3 comprised 60 patients with post-infarction cardiosclerosis and obesity. The research included patients who were treated at the State Institution “L.T. Malaya National Institute of Therapy of the National Academy of Medical Sciences of Ukraine” and in the first cardiology department of Kharkiv Clinical Hospital or Rail Transport No.1 of the “Healthcare Center” branch of the Joint Stock Company “Ukrainian Railways”. Determination of cartonectin and adropin levels was performed by enzyme-linked immunosorbent assays using the commercial test system Human CTRP 3 (Aviscera Bioscience Inc, Santa Clara, USA) and Human Adropin (Elabscience Biotechnology, USA). Statistical processing of the obtained data was performed using the statistical software package “IBM SPPS Statistics 27.0” and “GraphPad Prism software version 9.0.2”. For all types of analysis, the differences were considered statistically significant at p <0.05. One-factor analysis of variance was used to characterize the influence of factors on the indicators. The method of discriminant analysis was used to assess the occurrence of re-hospitalization. Results. The research revealed a decrease in CTRP 3 in the progression of CHF in patients with post-infarction cardiosclerosis in the presence and absence of concomitant type 2 DM or obesity. The effect of diastolic blood pressure, CHF, glucose, the presence of type 2 DM and obesity on the content of CTRP 3 and adropin was determined. Cartonectin has been shown to be a risk factor for re-hospitalization. An assessment scale for the likelihood of re-hospitalization in patients with post-infarction cardiosclerosis and concomitant type 2 DM or obesity has been developed. We analyzed clinical cases of re-hospitalization among patients with post-infarction cardiosclerosis in the presence of concomitant pathology. Conclusions: CTRP 3 has been shown to be associated with the progression of CHF in patients with post-infarction cardiosclerosis and comorbid pathology. The results indicate the effect of hypertension, CHF, type 2 DM and obesity on the content of cartonectin and adropin. As a result, it has been shown that cartonectin is a factor influencing the occurrence of re-hospitalization in patients with post-infarction cardiosclerosis in the presence of syntropic pathology. The proposed method allows to assess the likelihood of re-hospitalization in patients with post-infarction cardiosclerosis with comorbid pathology.

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confidence: 61%

Assessment of Re-Hospitalization Probability in Patients With Post-Infarction Cardiosclerosis and Comorbid Pathology

Koteliukh

2021

Scientific and practical journal

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“…Previous studies have demonstrated that adipose tissue serves as the primary energy storage organ of the body and has potent endocrine functions, since it secretes a variety of adipokines. CTRP is an adipokine superfamily of proteins discovered by Wong et al ( 15 ), which are structurally similar to adiponectin ( 15 ) and exhibit numerous functions, including blood lipid regulation ( 16 , 17 ), insulin sensitization ( 18 ) and anti-inflammatory effects ( 19 ). Structurally, CTRPs are predominantly homotrimers; however, some CTRPs exist as heterohexamers ( 20 ).…”

Section: Ctrp Family: General Characteristicsmentioning

confidence: 99%

Role of the CTRP family in tumor development and progression (Review)

et al. 2021

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C1q tumor necrosis factor-related proteins (CTRPs), which are members of the adipokine superfamily, have gained significant interest in the recent years. CTRPs are homologs of adiponectin with numerous functions and are closely associated with metabolic diseases, such as abnormal glucose and lipid metabolism and diabetes. Previous studies have demonstrated that CTRPs are highly involved in the regulation of numerous physiological and pathological processes, including glycolipid metabolism, protein kinase pathways, cell proliferation, cell apoptosis and inflammation. CTRPs also play important roles in the development and progression of numerous types of tumor, including liver, colon and lung cancers. This observation can be attributed to the fact that diabetes, obesity and insulin resistance are independent risk factors for tumorigenesis. Numerous CTRPs, including CTRP3, CTRP4, CTRP6 and CTRP8, have been reported to be associated with tumor progression by activating multiple signal pathways. CTRPs could therefore be considered as diagnostic markers and therapeutic targets in some cancers. However, the underlying mechanisms of CTRPs in tumorigenesis remain unknown. The present review aimed to determine the roles and underlying mechanisms of CTRPs in tumorigenesis, which may help the development of novel cancer treatments in the future.

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“…MCP-1 та ФНП-α можуть індукувати інфільтрацію та запалення макрофагів. Отже, активація PPAR-γ може зменшити інфільтрацію макрофагів і запалення жирових тканин 33 .…”

Section: Idfunclassified

“…У дослідженні виявлено зв'язок між низькими рівнями CTRP 3 59 і підвищеним ризиком розвитку ІХС та ЦД 2 типу 60 . Отже, ці метаболічні умови опосередковано пов'язані через ефекти CTRP 3 61 .…”

Section: значення Fabp 4 і Ctrp 3 у розвитку гострого інфаркту міокарда із супутнім цукровим діабетом 2 типуunclassified

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The Role of Energy Homeostasis and the Adipokine System in the Development of Acute Myocardial Infarction With Concomitant Type 2 Diabetes Mellitus

Koteliukh¹

2021

Modern Medical Science and Education in Ukraine and Eu Countries: Imperatives, Transformation, Development Vectors

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Circulating levels of CTRP3 in patients with type 2 diabetes mellitus compared to controls: A systematic review and meta-analysis

Cited by 14 publications

References 32 publications

Assessment of Re-Hospitalization Probability in Patients With Post-Infarction Cardiosclerosis and Comorbid Pathology

Assessment of Re-Hospitalization Probability in Patients With Post-Infarction Cardiosclerosis and Comorbid Pathology

Role of the CTRP family in tumor development and progression (Review)

The Role of Energy Homeostasis and the Adipokine System in the Development of Acute Myocardial Infarction With Concomitant Type 2 Diabetes Mellitus

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