Circulating levels of homocysteine in preeclamptic women

Khosrowbeygi, Ali; Ahmadvand, Hassan

doi:10.3329/bmrcb.v37i3.6196

Cited by 22 publications

(18 citation statements)

References 22 publications

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“…Premlata et al showed the mean levels of severe PE and mild PE 15.9±6.3 vs 12.3±4.2 (p value =0.01). 4 Several other studies were in consonance with the her results such as Khosrowbeygi A et al and Makedos G et al 6,10 Based on the findings of present study it can be concluded that maternal serum homocysteine seems to have a causal role in pathogenesis of pre-eclampsia, however measurement of homocysteine concentration did not determine the severity of pre-eclampsia. In present study the pre-eclamptic group had higher incidence of caesarean sections (56.66%).…”

Section: Discussionsupporting

confidence: 68%

“…7 Several other studies were in consonance with the present study. 5,6,[8][9][10] On the contrary Zeeman GG et al did not agree with our observations and there was no significant difference in maternal serum levels of homocysteine between pre-eclampsia and normal pregnancy (5.1±1.7 μmol/l vs 4.7±1.3 μmol/l p value =0.56) and they stated that serum homocysteine levels were not helpful in the prediction of PE. 11 Hietala R et al also stated that there was no difference between pre-eclampsia and normotensive women (6.42, 7.55μmol/l vs 6.45, 7.34 μmol/l).…”

Section: Discussioncontrasting

confidence: 54%

“…Maternal characteristics are depicted in Table 1 this matches with the observations by Premlata Mital et al 4 The mean age in their study was 24.55±3.4 years, and 24.00±4.41 as studied by Md.Mozammel Hoque et al 5 In contrast khosrowbeygi A Ahmadvand H showed a higher mean age of pre eclamptic group as (32.27±0.69). 6 The mean serum homocysteine levels in our study in study group were found to be 13.99±5.46 (μmol/l) and control group 6.03±2.58 (μmol/l), which was statistically significant (p value-0.002). Arpita p patel found mean value of homocysteine in control group and study group to be 13.45±4.40 μmol/l vs 19.96 umol/l ± 6.42±2.58 μmol/l with (p value -0.002).…”

Section: Discussionmentioning

confidence: 49%

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Hyperhomocysteinemia in pre-eclampsia: is routine screening rational?

Miglani

Nautiyal

Prakash

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Hypertensive disorders complicate upto 5 to 10% of all pregnancies. Though the exact cause of pre-eclampsia is still undecided, maternal hyperhomocysteinemia has been implicated as a risk factor for pre eclampsia, placental abruption and other vascular diseases. The objectives of present study were to estimate the levels of serum homocysteine in antenatal patients and to study the above parameters in patients of pre-eclampsia.Methods: A prospective observational study was performed with 30 pre eclamptic patients and an equal number taken as control having comparable demographic characteristics. Level of homocysteine was measured by an enzymatic method, using Diazyme homocysteine 2 reagent enzymatic assay kit on Beckman coulter analyzer in all the patients. Obstetrics and neonatal outcomes were observed in all the patients. The statistical analysis was done using unpaired T test for determining level of significance.Results: Mean Serum homocysteine in the study group was 13.99±5.46 µmol/l and was 6.03±2.58 µmol/l in control group. This was statistically significant (p value 0.002). However the mean values of serum homocysteine did not correlate with severity of pre-eclampsia 14.32±6.72 µmol/l in mild pre-eclampsia and 13.60±3.77μmol/l in severe pre-eclampsia respectively (p value - 0.727).Conclusions: It appears that maternal serum homocysteine has a causal role in pathogenesis of pre eclampsia, however to recommend it as a routine test, larger studies are required.

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Section: Discussionsupporting

confidence: 68%

Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 49%

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Hyperhomocysteinemia in pre-eclampsia: is routine screening rational?

Miglani

Nautiyal

Prakash

2017

Int J Reprod Contracept Obstet Gynecol

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“…Leeda et al (24) performed methionine loading tests on women with intrauterine growth retardation post-partum and found that 19.2% had hyperhomocysteinemia. It has been demonstrated that homocysteine levels are higher in preeclamptic women than those in normal pregnants (25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

İkinci trimester homosistein, B12 vitamini ve folat düzeylerinin olumsuz obstetrik sonuçlarla ilişkisi: Klinik çalışma

Ural¹,

Avşar²,

Danışman³

et al. 2015

Ege Tıp Dergisi

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Aim: The aim of this study is to determine if maternal serum levels of folate, vitamin B12 and homocysteine at 20-26 weeks of gestation are associated with subsequent adverse pregnancy outcomes. Materials and Methods:This prospective study was conducted in a tertiary care center and included 159 pregnant women at 20-26 gestational weeks. Complicated and uncomplicated pregnancy groups were compared in terms of serum levels of folate, vitamin B12, and homocysteine using Mann-Whitney U and t tests. Correlation of homocysteine with vitamin B12 and folate were analyzed with regression analysis. Results:Of the 159 participants, 32 (20.13%) suffered from pregnancy complications. There were no significant differences in the levels of the midtrimester homocysteine (p=0.25) and vitamin B12 (p=0.19) between healthy and complicated pregnancy groups. The significant difference in terms of folate levels (p=0.02) was considered to be clinically insignificant, since the measured levels were within normal range. There is a statistically significant inverse correlation between homocysteine and vitamin B12 levels (r = -0.407, p=0.013). Conclusion:Our results indicate that homocysteine, vitamin B12 and folate concentrations in mid-trimester are not associated with adverse pregnancy outcomes. These findings suggest that these markers seem not to have predictive value for pregnancy complications. Komplikasyon, folat, homosistein, ikinci trimester, gebelik, B12 vitamini. Keywords

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“…6 In a similar study done by Khosrowbeygi A and Ahmadvand H and Laskowska M et al maternal serum levels of total homocysteine were significantly higher in preeclamptic than in normal pregnant women. 7,8 Some studies suggested that infection and inflammatory processes are related to preeclampsia. The role of inflammation and infection in the pathogenesis of preeclampsia is significant in developing countries, where the high incidence of chronic subclinical infection may contribute to the high incidence of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of maternal serum levels of cell adhesion molecules and endothelial inflammatory markers in normal pregnancy, gestational hypertension and pre-eclampsia

Gupta

Arora

Kumar

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONPreeclampsia is a pregnancy specific disorder clinically characterized by hypertension, proteinuria or presence of multiorgan dysfunction. There is a growing body of evidence to indicate that endothelial dysfunction has a crucial role in the pathogenesis of pre-eclampsia.Members of the immunoglobulin superfamily of endothelial adhesion molecules, (vascular cell adhesion molecule (VCAM-1) and intercellular cell adhesion molecule (ICAM-1)) and endothelial inflammatory markers (homocysteine and TNF-α) participate in leukocyte adhesion to the endothelium and may play an important role in pathogenesis of Preeclampsia. For the ABSTRACT Background: Hypertensive disorders complicate 5 to 10% of all pregnancies. Despite the still unexplained pathogenesis, endothelial dysfunctions and inflammatory mediators are thought to be responsible for the pathogenesis gestational hypertension and pre-eclampsia. Aims and objective of the study was to determine the serum levels of cell adhesions molecules -VCAM-1 and ICAM-1 and endothelial inflammatory markers TNF-α and homocysteine in normal pregnancies, Gestational Hypertension and in Pre-eclampsia Methods: The cross-sectional study was carried out in Department of Obstetrics and Gynecology and Biochemistry, ESI-PGIMSR, New Delhi between October 2013-April 2015. 150 patients who gave informed written consent were enrolled and were divided equally in three groups of 50 each (normotensive, gestational hypertensive and preeclamptic patients). Three groups have been compared in terms of variables such as age, BMI, gestational age, systolic and diastolic blood pressure, platelet count, AST, ALT, mode of delivery, neonatal weight, VCAM-I, ICAM-I, homocysteine and TNF-alpha concentrations. Results: We found the higher concentrations of vascular cell adhesions molecules (VCAM-1 and ICAM-1) and inflammatory mediators (homocysteine and TNF α) in gestational hypertensive patients and in pre-eclamptic patients. Out of four markers, concentrations of ICAM-1 was found in largest proportions and it was also statistical significant. P value was <0.001. Though in our study concentration VCAM-1, homocysteine and TNF-α were also high in gestational hypertensive groups as compared with normotensive patients, but they were not statistical significant. Conclusions: We conclude that higher concentrations of vascular cell adhesions molecules and inflammatory mediators may be responsible for hypertensive disorders of pregnancy suggesting the role of endothelial dysfunction as a central pathogenic feature in development of preeclampsia.

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Circulating levels of homocysteine in preeclamptic women

Cited by 22 publications

References 22 publications

Hyperhomocysteinemia in pre-eclampsia: is routine screening rational?

Hyperhomocysteinemia in pre-eclampsia: is routine screening rational?

İkinci trimester homosistein, B12 vitamini ve folat düzeylerinin olumsuz obstetrik sonuçlarla ilişkisi: Klinik çalışma

Evaluation of maternal serum levels of cell adhesion molecules and endothelial inflammatory markers in normal pregnancy, gestational hypertension and pre-eclampsia

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