Circulating levels of hydrogen sulfide and substance P in patients with sepsis

Gaddam, Ravinder Reddy; Chambers, Stephen T.; Murdoch, David R.; Bhatia, Madhav

doi:10.1016/j.jinf.2017.07.005

Cited by 20 publications

(26 citation statements)

References 36 publications

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“…*<0.05, **p<0.01, ***p<0.001, ns = not significant. The plasma CRP and IL-6 data is supporting data reanalysed from Gaddam et. al.…”

Section: Discussionsupporting

confidence: 71%

“…al. [8]. The presented study is a continuation of that work and has used the same patient cohorts while investigating different biomarkers.…”

Section: Introductionmentioning

confidence: 93%

“…In juxtaposition, uNP, pNP,, uTNP, pTNP, IL-6 and CRP from patients in the sepsis group showed an overall decrease, which paralleled the improvements in daily SOFA scores. Unlike many of the conditions seen in the non-sepsis patients, sepsis is directly related to up-regulation of immune system and inflammation, which typically resolves with successful treatment [8]. Moreover, sepsis is a severe illness with systemic consequences which affects multiple systems and factors, including the ones that are used to generate SOFA scores.…”

Section: Time (Hours)mentioning

confidence: 99%

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Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis

et al. 2020

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Introduction: Neopterin and 7,8-dihydroneopterin are used as biomarkers of oxidative stress and inflammation, but the effect of kidney function on these measurements has not been extensively explored. We examine the levels of oxidative stress, inflammation and kidney function in intensive patients and compare them to equivalent patients without sepsis.Methods: 34 Intensive care patients were selected for the study, 14 without sepsis and 20 with. Both groups had equivalent levels of trauma, assessed by SAPS II, SOFA, and APACHE II and III scores. Plasma and urinary neopterin and total neopterin (neopterin + 7,8-dihydroneopterin) values were measured.Results: Neopterin and total neopterin were significantly elevated in urine and plasma for multiple days in sepsis versus non-sepsis patients. Plasma neopterin and total neopterin have decreasing relationships with increased eGFR (p<0.008 and p<0.001, respectively). Plasma/urinary neopterin and total neopterin ratios demonstrate that total neopterin flux is more influenced by eGFR than neopterin, with significantce of p<0.02 and p<0.0002 respectively.Conclusion: Sepsis patients present with greater levels of oxidative stress and immune system activation than non-sepsis patients of equal levels of trauma, as measured by neopterin and total neopterin. eGFR may need to be taken into account when accessing the level of inflammation from urinary neopterin measurements.

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“…*<0.05, **p<0.01, ***p<0.001, ns = not significant. The plasma CRP and IL-6 data is supporting data reanalysed from Gaddam et. al.…”

Section: Discussionsupporting

confidence: 71%

“…al. [8]. The presented study is a continuation of that work and has used the same patient cohorts while investigating different biomarkers.…”

Section: Introductionmentioning

confidence: 93%

Section: Time (Hours)mentioning

confidence: 99%

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Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis

et al. 2020

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“…However, NLRP3 expression was decreased, but NLRP1b was upregulated upon H 2 S treatment 293. H 2 S has a great potential to act as a prognostic marker of septic shock and its severity level becomes higher in septic patients within 12 hours of onset of sepsis 294,295. Even H 2 S can be detected in the exhaled pulmonary gases of patients with sepsis 296.…”

Section: Inflammasomes In the Immunopathogenesis Of Sepsismentioning

confidence: 99%

Inflammasomes: Pandora’s box for sepsis

Kumar

2018

JIR

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Sepsis was known to ancient Greeks since the time of great physician Hippocrates (460–377 BC) without exact information regarding its pathogenesis. With time and medical advances, it is now considered as a condition associated with organ dysfunction occurring in the presence of systemic infection as a result of dysregulation of the immune response. Still with this advancement, we are struggling for the development of target-based therapeutic approach for the management of sepsis. The advancement in understanding the immune system and its working has led to novel discoveries in the last 50 years, including different pattern recognition receptors. Inflammasomes are also part of these novel discoveries in the field of immunology which are <20 years old in terms of their first identification. They serve as important cytosolic pattern recognition receptors required for recognizing cytosolic pathogens, and their pathogen-associated molecular patterns play an important role in the pathogenesis of sepsis. The activation of both canonical and non-canonical inflammasome signaling pathways is involved in mounting a proinflammatory immune response via regulating the generation of IL-1β, IL-18, IL-33 cytokines and pyroptosis. In addition to pathogens and their pathogen-associated molecular patterns, death/damage-associated molecular patterns and other proinflammatory molecules involved in the pathogenesis of sepsis affect inflammasomes and vice versa. Thus, the present review is mainly focused on the inflammasomes, their role in the regulation of immune response associated with sepsis, and their targeting as a novel therapeutic approach.

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“…Previous work established that SP concentrations increase along with inflammatory cytokine production in the acute septic setting (7,8). This only establishes correlation and does not show that increased SP with subsequent binding to NK-1R causes the augmented mortality.…”

Section: Introductionmentioning

confidence: 90%

Neurokinin-1 Receptor Deficiency Improves Survival in Murine Polymicrobial Sepsis Through Multiple Mechanisms in Aged Mice

Mella

Stucchi

Duffy

et al. 2019

Shock

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Circulating levels of hydrogen sulfide and substance P in patients with sepsis

Cited by 20 publications

References 36 publications

Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis

Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis

Inflammasomes: Pandora’s box for sepsis

Neurokinin-1 Receptor Deficiency Improves Survival in Murine Polymicrobial Sepsis Through Multiple Mechanisms in Aged Mice

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Circulating levels of hydrogen sulfide and substance P in patients with sepsis

Cited by 20 publications

References 36 publications

Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis

Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis

Inflammasomes: Pandora&rsquo;s box for sepsis

Neurokinin-1 Receptor Deficiency Improves Survival in Murine Polymicrobial Sepsis Through Multiple Mechanisms in Aged Mice

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Inflammasomes: Pandora’s box for sepsis