Circulating Levels of Resistin, IL-6 and Lipid Profile in Elderly Patients with Ischemic Heart Disease with and Without Diabetes

Yaseen, Faisal; Jaleel, Anila; Aftab, Jawed; Zuberi, Adnan; Alam, Ejaz

doi:10.2217/bmm.11.104

Cited by 11 publications

(11 citation statements)

References 41 publications

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“…[ 16 ] Mean IL-6 level in the present study was similar to the level reported in a study from Pakistan in patients with CAD with diabetes and without diabetes. [ 17 ] Other studies have also reported higher level of IL-6 in patients with CAD. [ 8 16 ] Serum IL-6 levels are increased in diabetic, and hypertensive subjects[ 24 ] compared with those without these morbidities.…”

Section: Discussionmentioning

confidence: 99%

“…[ 8 ] Highly sensitive CRP (hsCRP) and IL-6 are also associated with increased risk of all-cause mortality, and their measurement improves the ability to predict the risk of cardiovascular events. [ 8 16 17 18 19 ] Inflammation and related cytokines also interact with various metabolic factors which are related to the atherosclerotic process such as hyperglycemia, dyslipidemia, and insulin resistance (IR).…”

Section: Introductionmentioning

confidence: 99%

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Association of inflammatory cytokines with traditional and nontraditional cardiovascular risk factors in Indians with known coronary artery disease

Mahalle¹,

Garg²,

Kulkarni³

et al. 2014

Ann Med Health Sci Res

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Background:Inflammatory processes are implicated in the etiology of cardiovascular disease (CVD). Data on the association of inflammatory markers with cardiovascular risk factors in Indian patients with CVD are limited.Aim:This study was conducted with the aim to evaluate the association of inflammatory markers with traditional and nontraditional cardiovascular risk factors in angiographically proven coronary artery disease (CAD) patients.Subjects and Methods:We studied the association of serum highly sensitive C-reactive protein (hsCRP) (0.1-37.9 mg/l), interleukin-6 (IL-6) (2-253.2 pg/ml) and tumor necrosis factor-alpha (TNF-α) (8-525.8 pg/ml) with cardiovascular risk factors in 300 (M: 216, F: 84; mean age: 60.9 (12.4) years) CAD patients. All patients were evaluated for anthropometry and cardiovascular risk factors, and blood samples were collected for biochemical and inflammatory markers. Statistical analysis was carried out using SPSS Version 20.Results:Mean hsCRP, IL-6 and TNF-α in study population were 11.7 (9.7) mg/l, 64.5 (75.2) pg/ml, and 25.3 (40.9) pg/ml respectively. A total of 73.6% (221/300) patients had hsCRP levels >3.0 mg/l. All inflammatory markers were significantly higher and showed a positive correlation with dyslipidemia, diabetes mellitus, and/or hypertension (HTN). TNF-α had a negative correlation with age and positive correlation with smoking. Only IL-6 and hsCRP had a positive correlation with insulin resistance and negative correlation with insulin secretion. Among lipid parameters, triglyceride had a positive correlation, and high density lipoprotein had a negative correlation with all inflammatory markers. There was a progressive increase in the percentage of subjects with diabetes, HTN, and dyslipidemia with increasing levels of inflammatory markers.Conclusions:Indian patients with CAD had significantly high levels of inflammatory markers, which were related to cardiovascular risk factors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of inflammatory cytokines with traditional and nontraditional cardiovascular risk factors in Indians with known coronary artery disease

Mahalle¹,

Garg²,

Kulkarni³

et al. 2014

Ann Med Health Sci Res

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“…Il‑6 plasma levels increase with the severity of heart failure, and high plasma levels of Il‑6 are an important prognostic predictor in patients with congestive heart failure (Tsutamoto et al, ). Furthermore, both clinical and experimental data suggest that increased blood pressure may be a stimulus for inflammation and consecutive atherosclerotic disease, because Il‑6 levels are not only elevated in hypertensive individuals (Chae et al, ; Naya et al, ) and DOCA‐salt treated Sprague Dawly rats (Seifi et al, ), but also in patients with ischemic heart disease with and without diabetes (Yaseen et al, ). However, no data exist concerning the mechanisms leading to increased pro‐inflammatory cytokine levels due to hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…Although these findings seem to be in contrast to our results, there are some differences in the protocols: the determination of contractility was assessed by the post rest potentiation (PRP) solely, incubation with Il‑6 was shorter and post‐incubation cell treatment was different. The absolute plasma levels of Il‑6 reported in literature are inconsistent, but in diseases like ischemic heart disease or sepsis, values of 20–140 ng/ml can be found (Scheiermann et al, ; Liao et al, ; Iba et al, ; Yaseen et al, ).…”

Section: Discussionmentioning

confidence: 99%

Interleukin-6 Contributes to the Paracrine Effects of Cardiospheres Cultured from Human, Murine and Rat Hearts

et al. 2014

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Cardiosphere-derived cells (CDCs) were cultured from human, murine, and rat hearts. Diluted supernatant (conditioned-medium) of the cultures improved the contractile behavior of isolated rat cardiomyocytes (CMCs). This effect is mediated by the paracrine release of cytokines. The present study tested the hypothesis, that the cardiovascular state of the donor's heart influences this effect on CMCs and tries to identify the responsible factors. CDCs were cultured from human tissue samples of cardiac surgery and from murine and rat hearts. The supernatants of cultured CDCs from hypertensive humans and rats showed a higher improvement of the contractile behavior of CMCs compared to CDCs of normotensive origin. Subsequently, the cytokine profile of the supernatants was analyzed. Among the cytokines elevated in supernatants originating from hypertensive humans or rats was Interleukin-6. CDCs were also generated from Interleukin-6(-/-) -mice and their wildtype littermates. The supernatant of the cultured Interleukin-6(-/-) -CDCs had no effect on the contractile behavior, whereas the supernatant of the Interleukin-6(+/+) -CDCs showed a positive effect. To confirm the hypothesis that Interleukin-6 contributes to the paracrine effects, CMCs were incubated with Interleukin-6. It improved the contractile function in a concentration dependent way. Finally, the effect of the supernatant of cultured CDCs derived from a hypertensive human sample could be abolished by simultaneous incubation with a specific Interleukin-6 antibody. CDCs release cytokines that improve the contractile behavior of CMCs. This effect is more intense in CDCs from hypertensive donors. Interleukin-6 is involved in this phenomenon.

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“…Yaseen et al grouped elderly patients in ischemic and nonischemic groups, as well as diabetic and nondiabetic groups. Ischemic geriatric patients in both the diabetic and nondiabetic groups had significantly higher plasma resistin levels (11). We also investigated the functional status of myocardium in stable CAD using a different method than GATED MPS.…”

Section: Discussionmentioning

confidence: 99%

Resistin predicts ischemia in myocardial perfusion scintigraphy

Yı́ldı́rı́m¹,

Erkan²,

Aşik³

et al. 2014

Turk J Med Sci

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Circulating Levels of Resistin, IL-6 and Lipid Profile in Elderly Patients with Ischemic Heart Disease with and Without Diabetes

Abstract: This study shows that the plasma resistin and IL-6 concentrations increased significantly in patients with ischemic heart disease with and without diabetes. This shows that there is a possible role of resistin and IL-6 in inflammatory processes, especially in atherosclerosis.

Cited by 11 publications

References 41 publications

Association of inflammatory cytokines with traditional and nontraditional cardiovascular risk factors in Indians with known coronary artery disease

Association of inflammatory cytokines with traditional and nontraditional cardiovascular risk factors in Indians with known coronary artery disease

Interleukin-6 Contributes to the Paracrine Effects of Cardiospheres Cultured from Human, Murine and Rat Hearts

Resistin predicts ischemia in myocardial perfusion scintigraphy

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