Circulating Levels of Visceral Adipose Tissue-Derived Serine Protease Inhibitor (Vaspin) Appear as a Marker of Musculoskeletal Pain Disability

Tarabeih, Nader; Kalinkovich, Alexander; Shalata, Adel; Livshits, Gregory

doi:10.3390/diagnostics10100797

Cited by 16 publications

(19 citation statements)

References 67 publications

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“…Moreover, intervertebral disk specimens for measurement of LBP biomarkers would be preferable, but not realistically obtainable in general population studies. However, determination of serum/plasma concentrations of several cytokines and other soluble molecules has been used successfully for monitoring the initiation, intensity, and progression of human LBP, 25 , 26 , 94–96 and our data are in agreement with these results. There is potential for residual confounding that we unfortunately cannot address.…”

Section: Discussionsupporting

confidence: 89%

“…Plasma levels of GDF-15, follistatin, and vaspin were detected by ELISA using DuoSet kits (R&D Systems, Minneapolis, MN, USA), as previously described. 25 , 26 Due to significant deviation of the respective distributions from normality assumptions, the original measurements were subjected to a log transformation and standardized prior to analysis.…”

Section: Methodsmentioning

confidence: 99%

“… 29–31 We also recently reported that circulating levels of visceral adipose tissue-derived serine protease inhibitor (vaspin) are significantly associated with LBP severity and disability. 26 In human subjects, vaspin was previously found to be negatively associated with obesity, waist and hip circumferences, systolic and diastolic blood pressure, duration of diabetes, cardiovascular diseases, and bone loss, serving as a protective factor for all these conditions. 32–34 …”

Section: Introductionmentioning

confidence: 99%

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Deciphering the Causal Relationships Between Low Back Pain Complications, Metabolic Factors, and Comorbidities

Tarabeih¹,

Kalinkovich²,

Shalata³

et al. 2022

JPR

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Purpose Low back pain (LBP) is one of the major disabling health conditions in aging societies presenting significant cost burdens to health and social care systems. Its complications and associated disability are often accompanied by mental disorders, metabolic comorbidities, changed body composition, and inflammation. However, their mutual relationships in LBP-associated disability remain unclear. Methods In the present case-control study, a self-report validated questionnaire was used to collect LBP disability data in an ethnically homogeneous Israeli Arab sample (489 males and 589 females). Body composition parameters were assessed through bioelectrical impedance analysis and plasma levels of soluble markers by EISA. Comorbidity status was assessed in personal interview and from the individual medical files. Results Our mixed multiple regression analysis identified that GDF-15 (β = 0.160, p = 2.95×10-8), vaspin (β = 0.085, p = 0.003), follistatin (β = 0.076, p = 0.001), extracellular water (β = 0.096, p = 0.001), waist hip ratio (β = 0.072, p = 0.009), mental disorders (β = 0.077, p = 0.001), and metabolic comorbidities (β = 0.059, p = 0.02) were significantly associated with LBP disability scores, when controlling for age and sex effects. Additive Bayesian network modelling further suggests that LBP disability appears to be directly influenced by age, sex, GDF-15, and extracellular water, and indirectly by mental and metabolic disorders, waist-hip ratio, and follistatin. LBP, in turn, seems to affect the vaspin levels directly. Conclusion Our data suggest the existence of a complex, age-associated, and probably hierarchical, relationship between LBP disability and mental and metabolic disorders, inflammation-related soluble markers, and body composition parameters.

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Section: Discussionsupporting

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Deciphering the Causal Relationships Between Low Back Pain Complications, Metabolic Factors, and Comorbidities

Tarabeih¹,

Kalinkovich²,

Shalata³

et al. 2022

JPR

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“…However, no pre-clinical studies have been performed on the effect of the application of resistin in neuropathic and nociplastic pain. As for vaspin, it was reported a significant association between vaspin circulating levels and low back pain [497], but not pre-clinical studies, have been performed with the aim of studying the effect of vaspin on neuropathic or nociplastic pain. Finally, there are no pre-clinical studies on the role of visfatin in pathological pain or its development.…”

Section: Adipokinesmentioning

confidence: 99%

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú

Homs

Boadas-Vaello

2021

IJERPH

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A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat body accumulation, triggering structural and functional changes in tissues, organs, and body systems. Research shows that this fat accumulation is responsible for several comorbidities, including cardiovascular, gastrointestinal, and metabolic dysfunctions, as well as pathological pain behaviors. These health concerns are related to the crosstalk between adipose tissue and body systems, leading to pathophysiological changes to the latter. To deal with these health issues, it has been suggested that physical exercise may reverse part of these obesity-related pathologies by modulating the cross talk between the adipose tissue and body systems. In this context, this review was carried out to provide knowledge about (i) the structural and functional changes in tissues, organs, and body systems from accumulation of fat in obesity, emphasizing the crosstalk between fat and body tissues; (ii) the crosstalk between fat and body tissues triggering pain; and (iii) the effects of physical exercise on body tissues and organs in obese and non-obese subjects, and their impact on pathological pain. This information may help one to better understand this crosstalk and the factors involved, and it could be useful in designing more specific training interventions (according to the nature of the comorbidity).

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“…Second, our thematic analysis of the survey comments may have over-or underrepresented certain sentiments among LBP practitioners. Third, in view of very recent data on possible markers of LBP [46,49], there will be a potential revision on the diagnostic approach. Future efforts might include a content analysis designed to detect geographical differences in clinical practice and perceptions.…”

Section: Limitationsmentioning

confidence: 99%

Common Clinical Practice for Low Back Pain Treatment: A Modified Delphi Study

Varrassi

Moretti

Pace³

et al. 2021

Pain Ther

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Introduction: Low back pain (LBP) is a common reason for adults to seek medical care and is associated with important functional limitation and patient burden. Yet, heterogeneity in the causes and presentation of LBP and a lack of standardization in its management impede effective prevention and treatment. Methods: We conducted a modified Delphi study to generate consensus statements for the diagnosis, management, and prognosis of LBP. A panel of five experts proposed 19 statements that were subsequently evaluated by physicians who treat LBP in their everyday clinical practice. Physicians were asked to validate statements in the form of a web survey assessing level of agreement on a five-point Likert-like scale. Results: Consensus (C 70% agreement) was obtained for all 19 statements. Strength of agreement and physician comments highlighted the importance of pain management, but also strategies to ameliorate functional limitation and prevent future LBP episodes. Respondents favored multidisciplinary approaches and multimodal management for LBP, although there was some ambiguity as to how multidisciplinary strategies could be feasibly incorporated into daily practice. Finally, the results indicated some conflict regarding the use of imaging for the diagnosis of LBP and how to classify LBP for targeted treatment. Conclusion: The results of this study provide a summary of favored clinical practice for the management of chronic LBP. While the consensus statements were generally agreeable to survey respondents, some areas of ambiguity, including how to increase the feasibility of multidisciplinary strategies, when and how to use diagnostic imaging in LBP, and LBP classification, necessitate clarification in future studies and guidelines.

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Circulating Levels of Visceral Adipose Tissue-Derived Serine Protease Inhibitor (Vaspin) Appear as a Marker of Musculoskeletal Pain Disability

Cited by 16 publications

References 67 publications

Deciphering the Causal Relationships Between Low Back Pain Complications, Metabolic Factors, and Comorbidities

Deciphering the Causal Relationships Between Low Back Pain Complications, Metabolic Factors, and Comorbidities

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Common Clinical Practice for Low Back Pain Treatment: A Modified Delphi Study

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