Circulating Levels of Visfatin/Pre–B-Cell Colony–Enhancing Factor 1 in Relation to Genotype, GFR, Body Composition, and Survival in Patients With CKD

Axelsson, Jonas; Witasp, Anna; Carrero, Juan Jesús; Qureshi, Abdul Rashid; Suliman, Mohamed E.; Heimbürger, Olof; Bárány, Peter; Lindholm, Bengt; Alvestrand, Anders; Schalling, Martin; Nordfors, Louise; Stenvinkel, Peter

doi:10.1053/j.ajkd.2006.11.021

Cited by 112 publications

(109 citation statements)

References 21 publications

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“…[7] The mechanism behind increased visfatin levels in ESRD patients may be due to the reduction in the renal clearance of visfatin as other adipocytokines.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, two recent studies have concluded that there may be a relationship between visfatin and endothelial dysfunction in patients with Type 2 diabetes mellitus and ESRD patients. [4,7] It is well known that inflammatory state and endothelial dysfunction in dialysis patients have negative effects on left ventricular structure and function. In particular, it has been claimed that these factors have a role of the development of LVH in dialysis patients.…”

Section: Discussionmentioning

confidence: 99%

“…There seems to be only one other in the literature that addresses this topic, but it offers corroborating evidence. [7] However, to the best of our knowledge, there is no study evaluating visfatin levels with respect to dialysis modalities.…”

Section: Introductionmentioning

confidence: 99%

“…The left ventricular mass index (LVMI) was calculated by the formula, LVM/(height) 2,7 . [11] Mitral inflow velocities were obtained by pulse wave Doppler in the apical four-chamber view with the sample volume placed at the tips of the mitral valve leaflets.…”

Section: Echocardiographymentioning

confidence: 99%

“…[4] Dialysis patients are suggested to have increased several adipocytokines (adiponectin, leptin, interleukin 6 [IL-6], tumor necrosis factor-α [TNF-α]), particularly due to low renal clearance. [7] This group of patients may be expected to have higher visfatin levels along with other adipocytokines. There seems to be only one other in the literature that addresses this topic, but it offers corroborating evidence.…”

Section: Introductionmentioning

confidence: 99%

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The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Erten

Ebinç

et al. 2008

Renal Failure

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Visfatin was recently defined as an adipocytokine; however, the pathophysiological role of visfatin is not completely understood. A few studies suggest that visfatin may be a new proinflammatory adipocytokine. The aim of the present study was to compare serum visfatin levels between hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) patients and evaluate the relationship between visfatin levels to IL-6, TNF-α, and left ventricular hypertrophy. Serum visfatin, IL-6, and TNF-α levels were measured by using the ELISA method, and echocardiographic evaluations were performed in 31 hemodialysis patients, 30 CAPD patients, and 21 healthy volunteers. Serum visfatin levels were higher in the CAPD group (265.27 ± 387.86 ng/mL) than hemodialysis (97.68 ± 244.96 ng/mL,) and control (41.33 ± 48.87 ng/mL) groups (p = 0.04, p = 0.01, respectively). No significant difference was observed between the hemodialysis and control groups. In univariate analysis, visfatin levels were positively correlated with IL-6 (r = 0.24, p = 0.03), TNF-α (r = 0.34, p = 0.002), and BMI (r = 0.26, p = 0.03) and negatively correlated with some left ventricular diastolic parameters [Em and Em/Am (r = −0.305, p = 0.01), (r = −0.251, p = 0.03), respectively]. No relationship was found between visfatin and left ventricular mass index. In the linear regression analysis, visfatin levels independently related with TNF-( (β = 0.369, p = 0.001) and p = 0.015). This study has found significantly higher levels of serum visfatin in CAPD patients when compared to healthy individuals. Increased visfatin levels seem to associate with proinflammatory cytokines such as IL-6 or TNF-α. As for the effects of on left ventricular structure and functions, visfatin might have negative effects on left ventricular diastolic function parameters but have no effects on left ventricular mass index.

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“…[7] The mechanism behind increased visfatin levels in ESRD patients may be due to the reduction in the renal clearance of visfatin as other adipocytokines.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Echocardiographymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Erten

Ebinç

et al. 2008

Renal Failure

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Serum Visfatin, Fetuin‐A, and Pentraxin 3 Levels in Patients With Psoriasis and Their Relation to Disease Severity

Okan

Baki

Yorulmaz³

et al. 2015

Clinical Laboratory Analysis

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Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases

Dakroub

Nasser

Kobeissy

et al. 2021

Journal Cellular Physiology

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Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/ NAMPT have been implicated in vascular remodeling, vascular inflammation, and atherosclerosis, all of which pose increased risks of cardiovascular events. In this context, increased levels of visfatin have been correlated with several upregulated pro-inflammatory mediators, such as IL-1, IL-1Ra, IL-6, IL-8, and TNF-α. Furthermore, visfatin is associated with leukocyte recruitment by endothelial cells and the production of adhesion molecules such as vascular cell adhesion molecule 1, intercellular cell adhesion molecule 1, and E-selectin, which are well known to mediate the progression of atherosclerosis. Moreover, diverse angiogenic factors have been found to mediate visfatin-induced angiogenesis. These include matrix metalloproteinases, vascular endothelial growth factor, monocyte chemoattractant protein 1, and fibroblast growth factor 2. This review aims to provide aThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Circulating Levels of Visfatin/Pre–B-Cell Colony–Enhancing Factor 1 in Relation to Genotype, GFR, Body Composition, and Survival in Patients With CKD

Cited by 112 publications

References 21 publications

The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Serum Visfatin, Fetuin‐A, and Pentraxin 3 Levels in Patients With Psoriasis and Their Relation to Disease Severity

Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases

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