Circulating Levels of Visfatin, Resistin and Pro-Inflammatory Cytokine Interleukin-8 in Acute Pancreatitis

Daniel, Paul; Leśniowski, Bartosz; Mokrowiecka, Anna; Jasińska, Anna; Pietruczuk, Mirosława; Małecka‐Panas, Ewa

doi:10.1159/000276986

Cited by 36 publications

(30 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The cut-off values of 11.9 ng/ml and 1.8 ng/ml respectively allows the higher ranges of radiological scores prediction. These results are consistent with another study, published in 2010, which demonstrates, that both adipokines may be possibly used for AP prognosis and disease monitoring [34]. …”

Section: Discussionsupporting

confidence: 93%

The clinical value of adipokines in predicting the severity and outcome of acute pancreatitis

et al. 2016

View full text Add to dashboard Cite

BackgroundRecent data shows that patients with severe acute pancreatic might benefit from early intensive therapy, enteral nutrition and timely transfer to specialized centers. The early prophylactic use of antibiotics in AP remains controversial. The role and need for new markers in stratification of acute pancreatitis is also uncertain. This study aims to evaluate the prognostic usefulness of adipokines in prediction of the severity and outcome of acute pancreatitis (AP).MethodsProspective study was conducted in four clinical centers. The diagnosis and severity assessment of AP was established according to the revised 2012 Atlanta classification. Adipokines, IL-6 and CRP levels were measured at admission and on 3rd day of hospital stay and compared with the control group. The predictive accuracy of each marker was measured by area under the receiver operating curve.ResultsForty healthy controls and 102 patients were enrolled in to the study. Twenty seven (26.5 %) patients had mild, 55 (53.9 %) - moderate and 20 (19.6 %) - severe AP. Only resistin (cut-off value 13.7 ng/ml) and IL-6 (cut-off value 473.4 pg/ml) were reliable early markers of SAP. IL-6 with cut-off value of 157.0 pg/ml was a predictor of necrosis. The peripancreatic necrosis volume of 112.5 ml was a marker of SAP and 433.0 ml cut-off value could be used to predict the need of interventions.ConclusionsThe prognostic value of adipokines in AP is limited. Only admission resistin levels could serve as an early predictor for SAP.The Lithuanian Regional Ethics Committee approved the study protocol (permission No. L-12-02/1/2/3/4) and all the patients and the control group provided written informed consent.

show abstract

Section: Discussionsupporting

confidence: 93%

The clinical value of adipokines in predicting the severity and outcome of acute pancreatitis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Agents elevated in body fluids of patients with severe acute pancreatitis (SAP) and animal models of acute pancreatitis (AP)1 2 include adipokines,3 4proteases like trypsin,5–8 unsaturated fatty acids (UFAs) such as oleic and linoleic acid (LA)1 9 10 or cytokines including interleukin (IL)-1β,11 IL-6,12–15 IL-8,12 15 16 monocyte chemotactic protein-1 (MCP-1)17 and tumour necrosis factor-alpha (TNF-α) 13. Scoring systems to risk stratify AP include these 17–20.…”

Section: Introductionmentioning

confidence: 99%

Peripancreatic fat necrosis worsens acute pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis collections

Noel

Patel

Durgampudi

et al. 2014

Gut

133

147

View full text Add to dashboard Cite

Background and aims Peripancreatic fat necrosis occurs frequently in necrotising pancreatitis. Distinguishing markers from mediators of severe acute pancreatitis (SAP) is important since targeting mediators may improve outcomes. We evaluated potential agents in human pancreatic necrotic collections (NCs), pseudocysts (PCs) and pancreatic cystic neoplasms and used pancreatic acini, peripheral blood mononuclear cells (PBMC) and an acute pancreatitis (AP) model to determine SAP mediators. Methods We measured acinar and PBMC injury induced by agents increased in NCs and PCs. Outcomes of caerulein pancreatitis were studied in lean rats coadministered interleukin (IL)-1β and keratinocyte chemoattractant/growth-regulated oncogene, triolein alone or with the lipase inhibitor orlistat. Results NCs had higher fatty acids, IL-8 and IL-1β versus other fluids. Lipolysis of unsaturated triglyceride and resulting unsaturated fatty acids (UFA) oleic and linoleic acids induced necro-apoptosis at less than half the concentration in NCs but other agents did not do so at more than two times these concentrations. Cytokine coadministration resulted in higher pancreatic and lung inflammation than caerulein alone, but only triolein coadministration caused peripancreatic fat stranding, higher cytokines, UFAs, multisystem organ failure (MSOF) and mortality in 97% animals, which were prevented by orlistat. Conclusions UFAs, IL-1β and IL-8 are elevated in NCs. However, UFAs generated via peripancreatic fat lipolysis causes worse inflammation and MSOF, converting mild AP to SAP.

show abstract

“…Visfatinin Nampt (nikotinamid fosforibozil transferaz) etkisi ile NADPH (nikotinamid adenin dinükleotid fosfat) oksidazı aktive ederek endotelyal disfonksiyonda direkt rol oynadığı gösterilmiştir 8 . Visfatinin dolaşımdaki seviyeleri RA, ülseratif kolit, ve akut pankreatit gibi hastalıklarda inflamasyon belirteçleri ve hastalık şiddeti ile korele bulunmuştur 5,6,11 . Yine SLE ve akut akciğer hasarı gibi hastalıklarda serum visfatin seviyelerinin sağlıklı kontrollere göre yüksek bulunması bu hastalıkların patogenezinde rol oynadığını düşündürmüştür 9,10 .…”

Section: Discussionunclassified

“…Visfatinin; TNF-α (tümör nekroz faktör α), IL-6 ve IL-1β'nın (interlökin 1β) ekspresyonunu artırdığı, nötrofil apoptozunu inhibe ettiği, periferik kan mononükleer hücrelerden (PKMH) sitokin üretimini indüklediği, antijen sunucu hücrelerini (ASH) aktive ettiği ve endotel disfonksiyonuna neden olduğu gösterilmiştir [5][6][7][8] . Visfatin seviyelerinin romatoid artrit (RA), inflamatuvar bağırsak hastalığı (İBH), sistemik lupus eritematozus (SLE), akut akciğer hasarı ve akut pankreatit gibi hastalıklarda yüksek bulunmuş olması visfatinin bu hastalıkların patogenezinde rolü olduğunu düşündürmüştür 5,6,[9][10][11] . Visfatinin BH patogenezindeki rolünü araştıran çalışmalar çelişkili sonuçlar vermiştir.…”

Section: Introductionunclassified

Behçet Hastalarında Serum Visfatin Seviyeleri Ve Hastalık Aktivitesi İle İlişkisi

Altunel¹,

Tatlıcan²,

Oktay³

et al. 2014

TURKDERM

View full text Add to dashboard Cite

Background and Design:Behçet's disease (BD) is a chronic inflammatory disorder. Genetic susceptibility, triggering infections and environmental factors that alter innate and acquired immunity are accused in its pathogenesis. Visfatin is a novel adipocytokine which exerts proinflammatory effects. In the present study, by comparing serum visfatin levels in patients with active BD with those in patients with inactive BD and healthy controls, we investigated the role of visfatin in the inflammatory process of BD. Materials and Methods:We enrolled 26 patients with active BD, 26 with inactive BD and 26 healthy controls in the study. Serum visfatin levels were analyzed by an enzyme-linked immunosorbent assay. White blood cell (WBC) count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and interleukin-6 (IL-6) levels were measured simultaneously and their correlation with visfatin levels were examined. Results: Age and gender distributions did not differ between the study groups (p=0.736 and p=1.00, respectively). Serum visfatin levels were significantly higher in patients with active BD (17.80±5.70 ng/mL) and inactive BD (12.80±2.90 ng/mL) than in controls (8.90±4.20 ng/mL), (p=0.00 for both comparisons). Active BD patients had significantly higher visfatin levels when compared to inactive BD patients (p=0.00). In all study groups, visfatin levels were positively correlated with WBC count, ESH, CRP, and IL-6 levels. Conclusion: Our results support the idea that visfatin plays a role in the inflammatory process of BD and suggest that visfatin may be a novel activity marker in BD. (Turkderm 2014; 48: 82-6)

show abstract

Circulating Levels of Visfatin, Resistin and Pro-Inflammatory Cytokine Interleukin-8 in Acute Pancreatitis

Cited by 36 publications

References 31 publications

The clinical value of adipokines in predicting the severity and outcome of acute pancreatitis

The clinical value of adipokines in predicting the severity and outcome of acute pancreatitis

Peripancreatic fat necrosis worsens acute pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis collections

Behçet Hastalarında Serum Visfatin Seviyeleri Ve Hastalık Aktivitesi İle İlişkisi

Contact Info

Product

Resources

About